Lunaphore, a Bio-Techne brand: Advancing oncology research with spatial biology

Prevention and treatment of colorectal cancer liver metastases represent a significant clinical challenge, requiring novel approaches to characterize disease biology. Dr. Xenia Maria Ficht will focus on the pivotal roles of cell-cell interactions during metastatic growth and treatment response. By leveraging spatial biology techniques, such as spatial transcriptomics and automated high-plex imaging, she will talk about comprehensively profile metastatic heterogeneity and characterize local tumor niches. This multimodal approach enables the identification of critical cellular interactions linked to disease progression and functional outcomes, providing valuable insights into metastatic tumor ecosystems. In addition, we will demonstrate how Lunaphore provides end-to-end solutions for spatial biology from multiplexed images to image analysis. We will present how the COMET™ platform performs sequential immunofluorescence (seqIF™) to obtain high-quality and reproducible data with standard off-the-shelf antibodies. COMET™ also integrates a signal amplification technology to enhance signal sensitivity for low-expressed or challenging markers, without compromising accuracy. Additionally, attendees will explore our innovative multiomics application that combines RNAscope™ and seqIF™ to simultaneously identify RNA and protein targets on the same tissue section in a fully automated workflow. We will unveil HORIZON™ image analysis, which transforms multiplexed images into spatial data. Our distinctive spatial biology approach empowers scientists to identify new molecular signatures and bolster the development of targeted therapies.