Genomic alterations drive tumor heterogeneity and therapeutic resistance, yet capturing these dynamics at single-cell resolution remains challenging. This session explores cutting-edge strategies integrating Oxford Nanopore’s multiomic sequencing with single-cell technologies to uncover novel cancer biology. We highlight a multiomic approach tracking clonal evolution in B-ALL and a novel method, ecSingle, revealing the role of extrachromosomal DNA (ecDNA) in tumor progression. Together, these insights provide a comprehensive and simultaneous view of genomic, epigenomic, and transcriptomic information across thousands of single cells linking genomic alterations to functional consequences. Learn how these innovations advance our understanding of cancer evolution, immune evasion, and therapy resistance.
| Time | Session |
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14:30
14:35
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Introduction
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14:35
14:55
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Bridging genotype and phenotype through single-cell and single-molecule multi-omics
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14:55
15:15
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Tumour heterogeneity and clonal selection of ecDNA at single-cell level
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