TUMOUR BIOLOGY

Heterogenous tumor immune microenvironment in mismatch repair deficient colorectal cancer patients receiving immune checkpoint inhibitor

The Effects of Palmitic Acid and Insulin as Diabetic Stress Markers in Breast Cancer Associated Fibroblast Model in vitro

Tumor budding cells express Trop-2 as a driver of colon cancer cell migration and invasion

Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia

The prostate specific SOCS1-deficient mouse model to study the gut-prostate axis in the pathogenesis of prostate cancer

LncRNA PRKCQ-AS1 promotes cancer cell proliferation and inhibits etoposide-induced apoptosis via modulation of HOX5A.

Erythrocyte-derived sphingosine-1-phosphate promotes tumor cell survival in the circulation

Deciphering the Role of TCF21 in Regulating the Cancer-Associated Fibroblast (CAF) State in High Grade Serous Ovarian Cancer

Defining the metastatic niche for colorectal cancer dissemination

Transcriptomics analysis identifies intronic RNAs in ER+/PR+ and HER2-enriched ductal breast carcinoma

Patterns of Bone Marrow Adipogenesis in Response to Chemotherapy

Reprogramming the immunosuppressive tumor microenvironment to overcome resistance to CAR T-cell immunotherapy in pancreatic cancer

The role of the neuronal-cancer crosstalk in melanoma brain metastases using hPSC-derived Assembloids

Immunomodulation of Glioblastoma Tumor Microenvironment by NF1-LRD-Loaded Extracellular Vesicles

Combined K8 and Apc loss-derived mouse model for colon-specific tumorigenesis

Impact of MAG-EPA supplementation on the prostate tumor immune microenvironment

Local and systemic interactions drive prostatic intraductal carcinoma dissemination.

Colorectal cancer hepatic metastasis modelling by advanced 3D bioprinting and demonstration of oncolytic viral chemotherapeutic delivery.

Three-dimensional Microtissues: An In-Vitro Platform to Recapitulate the Heterogeneity and Complexity of Head and Neck Squamous Cell Carcinoma

Tissue-specific fibroblast lipids drive epithelial cancer invasion

MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer- associated fibroblasts

Reprogramming of cancer-associated fibroblasts during the stepwise progression of colorectal cancer

Elucidating the molecular mechanisms involved in pancreatic cancer and liver microenvironment crosstalk facilitating liver metastasis

A novel approach for the analysis of spatial cell distributions in the tumor microenvironment to predict bevacizumab response

The role of the Hippo signaling pathway in gastric cancer initiation and progression

Characterization of Dormant Persistor Origins Using Longitudinal Live Imaging

Dysadherin-mediated CA9 expression shapes an acidic tumor microenvironment to accelerate colorectal cancer aggression

A novel TROP2 complex affects colon cancer mechanobiology by modulating the cytoskeleton architecture

Understanding the genetic heterogeneity within clonal spheroids and its interaction with the tumor microenvironment

MLK4 role in the cross-talk between triple-negative breast cancer cells and tumour-associated macrophages.

Secretomes of IFN-γ-Activated Colon Endothelial Cells Suppress Colorectal Cancer: Molecular Insights and Cell-Biological Effects

Neuroblastoma and the nervous microenvironment: partners-in-crime

Humanized mouse models for preclinical evaluation of novel immune cell therapies, check point inhibitors, and immune cell engagers

Exploring small nucleolar RNAs as predictors of radiotherapy outcome in breast cancer

The impact of CFTR impairment on endothelial cell and its role during tumor progression

Emerging Subtypes in Ovarian High Grade Serous Carcinoma: Decoding Genomic and Functional Landscapes

Establishing the Immune-Profile of Cholangiocarcinoma and the Utility of Human Precision-Cut Tumour Slices (hPCTS) as a Platform to Assess Immunotherapy Response

Secreted luciferases: a scalable, accessible, and 3R-compliant tool for longitudinal monitoring of autochthonous tumor growth in vivo

Understanding the Role of Leukemia Inhibitory Factor (LIF) in the Bone Metastatic Microenvironment

Monocyte/macrophage crosstalk with colorectal cancer in co-cultures - in vitro studies

Cellular enlargement causes mitotic errors and aneuploidy in cells that evade senescence following chemotherapy

Characterization of hPBMC-ASID and hPBMC-ASIDβ2m−/− models for Immune-Oncology Studies

Unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.

Cholesterol Transfer from PI-Activated TREM2+ Macrophages to Tregs Drives Lymph Node Immunosuppressive Pre-Metastatic Niche

Translational Value of Hepatic Dnaja3-deficient Mice in Preclinical Testing of Novel HCC Therapeutics

Autophagy activation in response to cigarette smoke: Exploring the disparity in laryngeal cancer incidence and outcomes between sexes in South Korea

Reprogrammed fibroblasts promote melanoma progression and immune evasion in the lymph node niche

The NRG1/ERBB axis as a potential target to prevent targeted cancer therapy resistance

Characterizing Neuron-Neuroblastoma circuit development and its role in tumor progression

Comprehensive screening of A-to-I editing in colorectal cancer: implications for tumour progression and therapeutic targeting.

The Role of Hypoxia-Inducible Factor-1α in shaping Cancer-Associated Fibroblast phenotypes in colorectal cancer

Large-scale integrative analysis of fecal samples sequencing data from healthy and CRC patients supports novel miRNA-mediated host-microbiota interactions

Identifying Metastatic Drivers and Biomarkers in Colorectal Cancer – the zAvatar model as a surrogate for patient metastatic potential

miR-27a Targets the Circadian clock circuitry to Drive Lung Adenocarcinoma Progression

Developing Comprehensive In Vitro and In Vivo Models: Patient-Derived Organoids (PDOs) and Xenografts (PDXs) for Morphological and Functional Analysis and Drug Screening in Head and Neck Squamous Cell

Peritoneum specific fibroblasts that can arise in response to various local disorders promote colorectal cancer peritoneal metastasis

N106S mutation in eIF6 may prevent tumour onset caused by mRNA translation defects in Shwachman-Diamond Syndrome

Identify the efficacy and mechanism of engineering UMSC/miR-145-5p-TRAIL and its derived exosome on hepatocellular carcinoma

The DNA repair factor NEI-like DNA glycosylase 3 activates tumor-associated macrophage polarization through regulating genomic stability in HCC

Characterization of cysteine peptidase interplay between different cell populations in tumour microenvironment

The effects of selected piRNAs on ovarian cancer stem-like cells through piRNA mimic transfection

Rab27a deficiency fuels pancreatic tumor growth via a pro-inflammatory, immune-promoting tumor microenvironment

Apoptosis-induced compensatory proliferation: optimization of colorectal cancer mouse model and establishment of mouse-derived organoids

Prognostic and Molecular Features Associated with Tumour Border Properties in Colorectal Cancer

Modelling bone marrow adipocyte-mediated therapy resistance in advanced prostate cancer: insights from 3D in vitro and humanized in vivo systems

The role of periostin in the adhesion of pancreatic cancer cells

Perilipin 2 in Adipocytes of Omental Tumor Microenvironment Promotes Ovarian Cancer Cell Survival and Metastasis Through CXCL12/CXCR4 Axis

Analysis of immunoglobulin producing tumour cells in colorectal cancer utilising highplex immunohistochemistry techniques

Reactivation of miR-29 Mitigates Epigenetic Deregulation and Tumor Progression in Advanced Prostate Cancer

Development of novel RNA aptamers for precision targeting of cancer-associated fibroblasts in NSCLC

TGFβ signaling in cancer-associated fibroblasts creates a pro-metastatic niche in colorectal cancer

Molecular characterization of long non-coding RNA MINCR isoforms and their impact on prostate cancer progression

The role of RNA Modifiers in Prostate Cancer Bone Metastasis: Insights from m6A RNA Methylation

A Multiomics Imaging Approach to Characterize lncRNA-Protein Dynamics in Colorectal Cancer Progression

Stromal-immune interactions shape the bone metastatic niche

The role of complement in pancreatic cancer: from complement activation and effector mechanism/s to combination with therapy

Exploring the Interactions within the Tumor Microenvironment of pancreatic neuroendocrine tumors (P-NETs)

Oncofetal-chondroitin sulfate, key to tumor immune surveillance?

XPO6-Mediated Immune Evasion Limits TCR-T Efficacy in Nasopharyngeal Carcinoma

Role of DDR1 in tumoral progression through matrix extracellular remodeling and discovery of a novel partner of DDR1 in colorectal cancer (CRC)

miR-30d inhibition activates the cGAS/STING/IFN-I pathway stimulating an innate immune response via LATS2/YAP axis in breast cancer

Characterization of extracellular vesicles derived from cancer-associated fibroblasts in oral squamous cell carcinoma

Repurposing Tricyclic Antidepressants for Glioblastoma Treatment

Metastatic peritoneal fibroblasts mobilize and respond to TGF-β1 from the extracellular matrix of colorectal cancer

Tumor Heterogeneity and Immune Modulation in Oesophageal Squamous Cell Carcinoma Characterised by Single-Cell RNA Sequencing Analysis

Multiomic profiling of colon cancer sidedness reveals TGFβ-driven EMT and Mast cell dynamics as key prognostic factors

Oxidative stress promotes Colorectal cancer aggressiveness through transmembrane Chloride Intracellular Channel 1 (tmCLIC1) antioxidant activity

Thrombospondin-1, RANK and OPG interactions in breast cancer osteolytic bone metastasis

Mouse intraductal model of ER+ breast cancer to study the role of HSF1 in its development.

Extracellular Matrix-Based 3D Head and Neck Cancer Model: A Biofabricated Platform for Testing Melatonin Therapy

Cellular and molecular features of the aberrant vascularization and mechanisms of TKI resistance in metastatic clear cell renal cell carcinoma

miR-31-3p inhibition as strategy to increase responsiveness to trastuzumab in HER2 positive breast cancer

Adaptation to chromosomal instability in colorectal cancer creates vulnerabilities in epigenetic and growth regulators

Harnessing Mechano-Modulation: Enhancing Nano-Immunotherapy Efficacy by Targeting the Tumor Microenvironment in Sarcomas and TNBC

Tunable Biomimetic Hydrogels to Reproduce the Breast Tumor Microenvironment for Advanced 3D Cancer Modeling

Mapping of human prostate tumour heterogeneity using AtlasPlex immunofluorescence approach

A Novel Transgenic Mouse Model to Assess On-Target Off-Tumor Toxicities of HER2-Targeted Therapies

ADAR1-Mediated RNA Editing as an Oncogenic Driver in Prostate Cancer

An mRNA isoform produced by intronic polyadenylation as a new signature in tobacco associated cancers

Functional role of unannotated small RNA cluster 1 (smRC1) during hepatocarcinogenesis and angiogenesis

Bidirectional interaction between Schwann cells and cancer cells of Hepatocellular carcinoma: implications for tumor progression.

Neurosurgery in glioblastoma induces proneural-to-mesenchymal transition, therapy resistance and immunosuppression by ischemic hypoxia

Development of a microphysiological system reflecting breast cancer lymph node metastasis

miR-574-5p is a regulator of ARV7 expression in a potential allele-specific manner

xRNA in Ovo: Target Validation and Efficacy Studies Using Chicken Embryo Model (CAM Assay)

Spatial profiling of the colonic immune microenvironment reveals modulation by intestinal estrogen receptor beta and sex

A Vascularized Tumor-on-Chip Model for Patient-Relevant Drug Screening in Non-Small Cell Lung Cancer

Targeting tumor hypoxia and immune blockade to improve breast cancer therapy

Dissecting the role of retinoic acid signaling in human chronic lymphocytic leukemia using novel 3D lymph node-like microenvironments

Deciphering the involvement of cancer associated fibroblasts on the aberrant vasculature in clear cell renal cell carcinoma and the resistance to targeted treatments

Decoding Sarcoma Complexity: Harnessing Xenopus tropicalis for In Vivo Studies of Liposarcoma, Desmoid Tumors, and Beyond

ETV6::JAK2 fusion promotes central nervous system invasion in murine B-cell acute lymphoblastic leukemia

Development of new in vitro organotypic cultures for the evaluation of anti-tumor drug sensitivity

Impact of Brain-Derived Neurotrophic Factor (BDNF) on Tight Junction (TJ) Proteins and Cell Adhesion and Migration in Breast Cancer: Implications for Brain Metastasis

Single-cell transcriptomics identifies vulnerabilities of osimertinib ex-vivo persister cells

A uveal melanoma murine model which faithfully recapitulates organotropism and dormancy

Genetic deconstruction of prostate cancer heterogeneity through a unique preclinical mouse modelling platform (ProMPt)

Engineered 3D osteosarcoma microenvironment model: Bridging in vitro - in vivo gap in cancer research and anticancer drug screening

Extracellular Vesicles from Melanoma-Associated Fibroblasts Promote Pro-Tumourigenic Changes in Brain Endothelial Cells

Androgen Receptor Loss Drives Nuclear Instability in Cancer-Associated Fibroblasts: A Novel Mechanism of Tumor-Stroma Remodeling

m6A epitranscriptome landscape in bladder tumors: translational impact in patients’ prognosis and treatment outcome

miR-214 Modulates Pigmentation and Therapy Resistance in Cutaneous Melanoma

Simple and cost-effective cancer diagnosis in liquid biopsy through native tRNA sequencing

CD44v6-Targeted CAR-T Immunotherapy to reduce metastatic evolution in Thyroid Cancer

IMPACT OF PREOPERATIVE TREATMENT ON THE TUMOR MICROENVIRONMENT OF LIVER METASTASES FROM COLORECTAL CANCER

3D Cell-derived ECM Production for Humanized Lung Cancer in vitro Model Development

Pancreatic Ductal Adenocarcinoma on Chip for Therapy Screening

Standardization of a Murine Model of Colorectal Cancer Induced by AOM/DSS and Evaluation of the Chemopreventive Capacity of the 5-Fluorouracil-Curcumin Hybrid

Biogenesis of miR-155 under oxidative stress in lymphoma cells

circRNAs-miRNAs-mRNAs regulatory axis of genes associated with hereditary prostate cancer: in silico analyses for screening potential biomarkers

Drugable oncofetal RBP Musashi-1 provides a novel Approach for Therapy in immunologically cold High-grade Serous Ovarian Cancer Tumors

Cellular Model of Giant Cell Tumor of Bone: Insights from In Vitro and In Vivo Studies