EXPERIMENTAL / MOLECULAR THERAPEUTICS, PHARMACOGENOMICS

18/06/2025 10:45 20:00

Poster and Exhibition Hall

Time	Session

10:45 20:00	Preventive and Therapeutic Effects of Amaranthus hybridus and Corchorus olitorius on Breast Cancer P-398 EACR25-0009 Emeka Eze Joshua Iweala Poster Presenter Nigeria	Phage display identified claudin 18.2 binding peptide for early pancreatic diagnosis and tumor-target killing. P-399 EACR25-0047 Poongkavithai Vadevoo Sri Murugan Poster Presenter Korea (Republic of)	Nanobody-PROTACs: Method development towards the use of single-domain antibody proteolysis-targeting chimera constructs (sdAb-PROTACs) to target 'undruggable' proteins for degradation P-400 EACR25-0065 Caroline Hannah Cope Poster Presenter United Kingdom	Impact of immune checkpoint inhibitors (ICIs) alone or combined with chemotherapy (ICI/chemotherapy) on the prognosis of non-small cell lung cancer (NSCLC) patients with high expression of programmed P-401 EACR25-0085 Jin Gu Chen Poster Presenter China	A potential nanocarrier for Androgen-resistant in prostate cancer: Green synthesis of ZnO nanoparticle P-402 EACR25-0087 Ms. Salida Ali Poster Presenter	Preclinical Evaluation of RAS(ON) Multi-Selective Inhibitors as a Therapeutic Strategy for KRAS mutant Cholangiocarcinoma P-403 EACR25-0175 Konstantina Morali Poster Presenter Spain	Development and Validation of a Novel Multi-Functional Iron Oxide Nanoparticle for the Targeted Induction of Ferroptosis in Cancer P-404 EACR25-0295 Darius McPhail Poster Presenter United Kingdom	Innovative Cyclic Peptide Disrupts IL-17RB/MLK4 Interaction for Targeted Pancreatic Cancer Therapy P-405 EACR25-0301 Chun-Mei Hu Poster Presenter Taiwan	Rationally designed cholesterol-coated peptide nanosponges as a novel therapeutic strategy in the management of Adrenocortical Carcinoma P-406 EACR25-0375 Mariam Hassany Poster Presenter Ireland	Targeting Estrogen-Related Receptor Gamma (ERRγ) in Ovarian Carcinoma: Therapeutic Potential of DN200434 and MK2206 Combination in-vitro and in-vivo P-407 EACR25-0411 Deepak Gulwani Poster Presenter India	canSERV – providing cutting edge cancer research services across Europe P-408 EACR25-0521 Manuela Pausan Poster Presenter Austria	Targeting PDGFRA in Pediatric High-Grade Gliomas: Insights from Brazilian Preclinical Models P-409 EACR25-0539 Mirella Baroni MIlan Poster Presenter Brazil	Patient-Derived Glioma Organoids Resist Standard Therapies but Respond to Targeted Inhibition P-410 EACR25-0549 Alvaro Monago S Poster Presenter Spain	Combining in silico and in vitro approaches to repurpose candidate drugs for oral squamous cell carcinoma P-411 EACR25-0559 Marina Silva Rodrigues de Souza Poster Presenter Brazil	Glioma Targeting Peptide-Drug Conjugates: Comparative in vitro and in vivo evaluation P-427B EACR25-0569 Ivan Randelovic Poster Presenter Hungary	Anti-cancer effects of Amiodarone via cell cycle arrest, mitochondrial dysfunction, excessive autophagy, and increased apoptosis in thyroid cancer cells P-412 EACR25-0623 Seunghyeon Ahn Poster Presenter Korea (Republic of)	UD-086 overcomes trastuzumab deruxtecan-resistance and has a best-in-class therapeutic index in MMAE-based antibody drug conjugates P-413 EACR25-0627 Naoya Oishi Poster Presenter Japan	SELECTIVE DEGRADATION OF MLK3 BY NOVEL CEP1347-VHL-02 PROTAC COMPOUND LIMITS ONCOGENIC POTENTIAL OF TNBC P-414 EACR25-0653 Kamila Karpinska Poster Presenter Poland	EZH2 inhibitors dramatically sensitize breast cancers to HER2 kinase inhibitors through cooperative effects on YAP and pro-apoptotic regulators P-415 EACR25-0667 Naiara Perurena Poster Presenter United States	Pre-clinical Evidence for Ivacaftor as a Potential Repurposed Therapy for High-Grade Serous Ovarian Cancer and Endometrial Cancer P-416 EACR25-0683 Dongli Liu Poster Presenter Australia	Synergistic antineoplastic Effects of Jania rubens Extracts with Conventional Chemotherapy in Colorectal Cancer. P-417 EACR25-0701 Zeina Tarek Dassouki Poster Presenter Lebanon	1959-sss/DM4 Antibody-Drug Conjugate targeting extracellular LGALS3BP Exhibits Potent Antitumor Activity in orthotopic Glioblastoma Models P-418 EACR25-0709 Emily Capone Poster Presenter Italy	Bufalin Targets Protein Translation and Cell Metabolism to Overcome Therapy Resistance in Melanoma P-419 EACR25-0741 Aline Genbauffe Poster Presenter Belgium	FAM46C expression sensitizes multiple myeloma cells to PF-543-induced cytotoxicity P-421 EACR25-0779 Ivan Ferrari Poster Presenter Italy	An intracellular cytidine deaminase biodegrader to overcome cancer chemoresistance P-422 EACR25-0795 Marie SORBARA Poster Presenter France	dTAG-based degradation of CDK5 as a therapeutic strategy in colorectal cancer P-423 EACR25-0823 Ferran Grau Leal Poster Presenter Spain	Multiomic characterization and high-throughput drug testing of patient-derived NSCLC organoids P-424 EACR25-0863 Azadeh Motavallian Poster Presenter Germany	Sesquiterpene Lactones Cynaropicrin and Ludartin as Potential Therapeutic Agents in Ovarian Cancer P-425 EACR25-0867 Arya Akda_ Poster Presenter Turkey	Unlocking the Therapeutic Potential of Platelets in B-Cell Malignancies – Preliminary Study P-426 EACR25-0883 Joana Jorge Poster Presenter Portugal	Designer proteins to drive the targeted degradation of tankyrase P-427 EACR25-0889 Huey Ying Kok Poster Presenter United Kingdom	Alectinib enhances response to RBM39 degradation via SRPK1 inhibition in high-risk neuroblastoma P-427A EACR25-0895 Yurui Ma Poster Presenter United Kingdom	Targeting MYC as a promising therapeutic strategy for pediatric medulloblastoma P-428 EACR25-0925 Laura Escudero Poster Presenter Canada	Optimizing Gemcitabine Delivery: HPMA Copolymer Conjugates with Controlled Drug Release and Immunomodulatory Activity P-430 EACR25-0983 Kate_ina B_halov Poster Presenter Czech Republic	Discovering ERBB signaling as therapeutics target for β-catenin mutation driven hepatocellular carcinoma using mouse organoid platform P-431 EACR25-0993 Tin Lok WONG Poster Presenter Hong Kong, China	CircRNA-mediated inhibition of miRNA-454 as a novel therapeutic strategy in prostate cancer P-432 EACR25-1025 Achim Aigner Poster Presenter Germany	Preclinical Evaluation of T-DXd and AZD1390 in HER2-Low, Triple-Negative Breast Cancer Models P-433 EACR25-1129 Larissa Bless Poster Presenter Ireland	Reactivating the crosstalk between natural killer and tumour cells in non-small cell lung cancer (NSCLC) patients with no actionable mutations P-434 EACR25-1165 Cavassi Elena Poster Presenter Italy	Harnessing the impacts of a G-quadruplex ligand in liposarcoma: Implications for MDM2 oncogene targeting and DNA damage-mediated immunomodulatory effects P-435 EACR25-1173 Eisa Naghshineh Poster Presenter Italy	Synthetic Danshen Compound Inhibits Adipogenesis, Promotes Adipocyte Browning, and Induces G1 Cell Cycle Arrest While Suppressing Tumor Cell Migration and Invasion in Prostate Cancer Cells P-436 EACR25-1193 Ching-Feng Cheng Poster Presenter Taiwan	Investigating BCL3 as a therapeutic target to treat prostate cancer P-437 EACR25-1285 Marcos Quintela-Vazquez Poster Presenter United Kingdom	The RUVBL1/2 Complex: An Actionable Molecular Target in Bladder Cancer P-438 EACR25-1321 Buse Akdemir Poster Presenter Turkey	Cold-pressed lingonberry (Vaccinium Vitis-Idaea) extract inhibits proliferation, invasion and glycolysis of oral carcinoma cells P-439 EACR25-1325 Tuulia Onali Poster Presenter Finland	Discovery of a novel 1,2-epoxysteroid oxime with potent anti-pancreatic cancer activity P-440 EACR25-1327 Maria Filomena Botelho Poster Presenter Portugal	Unveiling the Therapeutic Potential of Tick Salivary microRNAs in Cancer Treatment P-441 EACR25-1329 Juan Antonio Marchal Poster Presenter Spain	Boronated derivatives with a carborane cage, sulfamido group, and Gd-DOTA for B/Gd-NCT with Carbonic Anhydrase IX inhibition. P-442 EACR25-1331 Sahar Rakhshan Poster Presenter Italy	Investigating the cytotoxic effects of rhenium (V) complexes with apigenin and derivatives P-443 EACR25-1333 Ana Radovan Kandi_ Poster Presenter Serbia	Arginine deprivation, mTOR signalling and DNA repair response in models of ovarian cancer P-444 EACR25-1347 Laila Cedra Evangelista Poster Presenter United Kingdom	Co-targeting of EGFR and Sp1 to inhibit TKIs resistance and improve immune response in NSCLC tumors P-445 EACR25-1359 Francesca Iommelli Poster Presenter Italy	Characterisation of bicyclic drug conjugate tool molecules using complementary 2D and 3D cellular models in vitro P-446 EACR25-1363 Jennifer Bre Poster Presenter United Kingdom	Diphyllin, a SPP1/DKK1 inhibitor, restricts hepatocellular carcinoma growth by modulating sugar and bile acid metabolism P-447 EACR25-1373 Jinfang Zhang Poster Presenter China	Transcriptional profiling and ex vivo drug pre-screen for personalized therapy selection P-448 EACR25-1419 Audrey Gal Poster Presenter Switzerland	Remodeling the Tumor Microenvironment through TSP-1/CD47 Antagonization: Non-Clinical Characterization of the TAX2 drug candidate P-449 EACR25-1421 Aur Poster Presenter France	A Novel High-Throughput Assay for Targeted Protein Degradation: Application to BCL-xL in Cancer Cells P-450 EACR25-1429 DANIELE CARETTONI Poster Presenter Italy	Novel Titanocene-derived complex with high albumin affinity: Evaluation of antitumor activity in ovarian cancer cells P-451 EACR25-1449 Virginia Pérez Garrido Poster Presenter Spain	Lysosomal Stress as an Off-target Effect of UNC0642 in Pancreatic Cancer Cells P-452 EACR25-1465 Ana Clara Albuquerque Poster Presenter United Kingdom	Development of GD2-Targeted Herpes simplex vectors for OncoVirotherapy P-453 EACR25-1553 Alessandra Napolano Poster Presenter Italy	Therapeutic deep eutectic systems as promising selective therapeutic agents in the anticancer battle P-454 EACR25-1579 Filipe Oliveira Poster Presenter Portugal	Identification and Validation of new In-Silico Designed MYC Binders P-455 EACR25-1583 Janice Wenzheng Neng Poster Presenter United Kingdom	Investigation of novel anti-leukemic compounds uncovered through high-throughput screening of human model leukemias P-456 EACR25-1585 Karla Lucia Paez Martinez Poster Presenter Canada	Potential of inhibition of AR to enhance the sensitivity of OVCAR-3 cells to PARP inhibitor P-458 EACR25-1595 Nevenka Gligorijevic Poster Presenter Serbia	Targeting Invasive Behavior in 2D, 3D, and In Vivo Models with Pentamethinium Salts as Migrastatic Agents P-459 EACR25-1691 Katerina Petrlakova Poster Presenter Czech Republic	Rhenium Complexes as Promising Selective Anticancer Agents P-460 EACR25-1725 Anna Pogorzelska Poster Presenter Poland	Mechanism of Action of DNA Polymerase Inhibitors in Triple-negative Breast Cancer Cells and Anti-tumor Effects in an Intraductal Breast Cancer Mouse Model P-461 EACR25-1733 Nadine Darwiche Poster Presenter Lebanon	Targeting RSK1 in Colon Cancer: Discovery and Evaluation of a New Small Molecule Inhibitor P-462 EACR25-1745 Ufuk Mulhim Poster Presenter Turkey	Mitochondrial Transplantation from Oxidatively Stressed Adipocyte-Derived Mitochondria Induces Ferroptosis in Glioblastoma P-463 EACR25-1751 Junbo Liao Poster Presenter Hong Kong, China	Patient-Derived 3D metastatic melanoma models for target discovery and personalized therapy P-464 EACR25-1779 Anshika Katyal Poster Presenter Israel	Pan-cancer therapy using oncofetal-chondroitin sulfate targeting antibody-drug-conjugates P-465 EACR25-1795 Elena Vidal-Calvo Poster Presenter Denmark	EGFR targeting restores primary cilia loss upon ETS-driven oncogenic transformation in prostate cells P-466 EACR25-1803 Sofia Oliveira Costa Poster Presenter Portugal	Combination of cerium oxide nanoparticles and antimalarial drug chloroquine: characterization and anti-cancer potential for triple negative breast cancer P-467 EACR25-1843 Chantal-Kristin Wenzel Poster Presenter Germany	The role of drug efflux and uptake transporters in the plasma and tissue disposition of KRASG12D inhibitor MRTX1133 P-468 EACR25-1851 Davinia Arguedas Poster Presenter Netherlands	Identification of a new ERK5 kinase inhibitor P-469 EACR25-1863 Ylenia Sfragano Poster Presenter Italy	Dual-Active Peptides: A Promising Therapy for Brain Metastases P-470 EACR25-1887 Vera Neves Poster Presenter Portugal	Optimization of Bivalent Immunoliposome Preparation for Selective Cytotoxic Activity Against Triple-Negative Breast Cancer Cells P-471 EACR25-1899 Ma_gorzata Milczarek Poster Presenter Poland	The development of a USP7 inhibitor for cancer immunotherapy P-472 EACR25-1913 Angelika Muchowicz Poster Presenter Poland	Isolation of anti-proliferative bioactive compounds from Gypsophila erocalyx plant extracts by activity-guided approach and its activity in prostate cancer P-473 EACR25-1971 B Poster Presenter Turkey	Synergistic effect of 5-fluorouracil and the small molecule Wnt/ P-474 EACR25-2017 Maren Smarslik Poster Presenter Germany	Identification of HMGA protein inhibitors as potential cancer therapy P-475 EACR25-2087 Sabrina Battista Poster Presenter Italy	Idasanutlin in combination with PD-1 blockade - synergy or antagonism? P-476 EACR25-2115 Lukasz Skalniak Poster Presenter Poland	Multiparametric Analysis of High-Throughput 3D Imaging-Based Drug Screening Reveals Cancer Drug-Induced Vulnerabilities in Patient-Derived Metastatic Colorectal Cancer Organoids P-477 EACR25-2119 Gizem Damla Yal Poster Presenter Turkey	Celastrol induces pro-apoptotic and anti-migratory effects against medulloblastoma subtypes P-478 EACR25-2123 Julia Morovis Marchetti Cassarotti Poster Presenter United Kingdom	Localized Drug Delivery for Cachexia-inducing Tumors: Overcoming Systemic Treatment Challenges P-478A EACR25-2171 Vito Telebar-Zbulj Poster Presenter Austria	Nanocarriers for Targeted Boron Delivery to Tumor Cells in BNCT Applications P-479 EACR25-2245 Julieta Nicole Pi Poster Presenter Italy	Antitumor immune mechanisms elicited by NLRC5 expression in cancer cells P-480 EACR25-2253 Sheela Ramanathan Poster Presenter Canada	Preclinical validation of a promising protein-protein interaction peptide inhibitor towards metastatic breast cancer P-481 EACR25-2293 Marco Cavaco Poster Presenter Portugal	Development of an optogenetic lytic system in E.coli based on phage-derived lytic proteins as a light-controlled and safe drug delivery platform. P-482 EACR25-2303 Annapaola Petrosino Poster Presenter Italy	Triptolide induces pro-apoptotic effects against medulloblastoma subtypes P-483 EACR25-2325 Hannah Eastham Poster Presenter United Kingdom	Identifying on-target and off-target effects of hundreds of oncology drugs in PRISM large-scale cell line profiling with machine learning analysis of baseline and functional genomic features P-484 EACR25-2329 Jennifer Roth Poster Presenter United States	Assessment of novel therapeutic treatments in KRAS mutant Colorectal Cancer using Patient-Derived Organoids P-485 EACR25-2331 Melania Lazzari Poster Presenter Italy	Evaluation in vitro and in vivo of the therapeutic effect of the melatonin-furanochalcone hybrid in colorectal cancer P-486 EACR25-2371 Vanesa Bedoya Poster Presenter Colombia	Anagrelide induced remodeling of the PDE3-SLFN12 interactome provides insights into translation initiation dynamics and molecular glue mechanisms P-487 EACR25-2381 Sami Ilmari Salmikangas Poster Presenter Finland	Antitumoral compounds: a nutraceutical approach in cancer therapy P-488 EACR25-2443 Antonella cusimano Poster Presenter Italy	Comparative analysis of proteomics and transcriptomics in patient-derived tumoroids for precision oncology and drug discovery P-489 EACR25-2475 Sara P Poster Presenter Spain	Coffee Exosomes Have Distinct Effects on Melanoma and Glioblastoma Cancer Cells via PTEN Tumor Suppressor Protein P-490 EACR25-2477 Ela Doruk Korkmaz Poster Presenter Turkey	Highly-targeted personalised siRNAs for BRAF-fusions inhibit melanocytic proliferation P-491 EACR25-2497 Sara Barberan Martin Poster Presenter United Kingdom	Evaluation of pleural mesothelioma sensitivity to targeted DNA damage response inhibitors P-492 EACR25-2499 FARIHA IDREES Poster Presenter Italy	Preclinical Evaluation of Novel Phosphoinositide 3-Kinase Inhibitors: Antitumor Activity and Toxicity Assessment P-493 EACR25-2559 Renato Jos Poster Presenter Brazil	Isothiocyanate-derived mercapturic acids potentiate tubulin polymerization inhibitors anticancer activity in urinary bladder cancer models (in vitro and in vivo studies) P-494 EACR25-2601 Mateusz Psurski Poster Presenter Poland