POSTER SESSION - Wednesday

Deciphering Tumor-Immune Crosstalk Through Multiplexed Imaging-Powered Deep Visual Proteomics (mipDVP)

A clinically interpretable machine learning model using 19 proteins to predict recurrence/metastasis in OSCC patients

Identification of Olverembatinib as a Potential Inhibitor for ROR1+ Triple-negative Breast Cancer

Integrated Genomic and Structural Analysis Reveals Novel Insights into Polymerase Proofreading Deficiency Drivers

nf-hlamajority: a Nextflow pipeline for consensus MHC class I genotyping and its application to neoantigen identification in breast and lung cancer stromal cells

Integrative analysis of the TBXT-driven transcriptome and proteome in chordoma

Classification of Small Blue Round Cell Tumors via mass spectrometry imaging of peptide and glycan content.

Comprehensive Pan-Cancer Multi-Omics Investigation of GCH1: Unraveling the Critical Role in Epithelial-Mesenchymal Transition

Describing Molecular Alterations in Breast Cancer Through a Multi-Omics Lens

Radiomics-based survival prediction in glioblastoma using the RaSPr score

Multimodal inference of morphogenomic phenotypes using morphology and expression data optimal clustering (MEDOC)

AI-Powered Nuclei Segmentation in Cervical Cytology: Advances with Deep Learning Models

Comprehensive machine learning analysis of high-dimensional radiomics datasets by PYRAMID

Machine Learning Algorithms for Prediction of Bone Metastasis Risk in Patients with Lung Cancer

Single-nuclei transcriptome profiling reveals vascular endothelial cell heterogeneity induced by VEGFA/BRAF targeting in murine melanoma model

Characterization of a new breast cancer classification and identification of key regulators

Investigating molecular evolution of tumor heterogeneity at recurrence unveils patient-specific trajectories

Unified Whole Genome Sequencing for Hematological Malignancies

DTFD-MIL-CN: A Cost-Effective and Accurate Deep Learning Model for Hormone Receptor–Positive, HER2-Negative Breast Cancer Distant Recurrence Risk

Deep transfer learning for predicting BRAF V600E mutation status in colorectal cancer using image-derived features associated with microsatellite instability

Spatial Transcriptomics Reveals Immune-Tumor Interactions Associated with Pembrolizumab Response in NSCLC

Machine Learning Meets Man’s Best Friend: Uncovering Prognostic Factors in Canine Mammary Tumors

Deciphering the Molecular Impact of Asbestos: Gene Expression Profiles in Malignant Pleural Mesothelioma

Pan-cancer analysis of signaling pathways regulatory connection with pyrimidine metabolism and its chemoresistance role

Enabling Clinical and Early-Phase Drug Development Applications through Single-Sample Tumor Archetype Assignment

Artificial Intelligence-Based Polyp Size Measurement: Multinational Validation Across Endoscopic Datasets

Accelerating real world data collection using Large Language Models in rare neoplasms. A bone sarcoma example. 

Pan-Cancer Analysis Identifies Dorsomorphin Dihydrochloride as an Anticancer Drug Targeting the Notch Signaling Pathway

Proteomic Analysis of the Pd(II) Complex-Induced Changes in HeLa Cervical Cancer Line

MOKCa-3D Database: Functional and structural analysis of gain-of-function and loss-of-function missense mutations in cancer.

The S-RACE Platform: Empowering Healthcare Real-World Data with Artificial Intelligence (AI) Using a Cloud-Based Approach

integrative Molecular Tumor Board (iMTB): A Decision-Support Tool for Precision Cancer Medicine in iCAN

Evaluating computational and enzymatic strategies for artifact removal in FFPE-derived NGS data

Optimization of U-Net-based semantic segmentation of fluorescence microscopy images

Comprehensive Analysis of Fusion Transcripts in HCC: Implications for Gene Expression and Tumor Progression

Unraveling Osteosarcoma Heterogeneity: molecular subtyping of early-stage osteosarcoma

Leveraging SHAP Values from Machine Learning and Mutational Signatures in Supervised Clustering to Enhance Disease-Specific Survival Prognosis in Endometrial Carcinoma

Tumor Growth Dynamics and Telomere Maintenance in Sarcoma: Insights from 3D Spheroid Models

The effect of common germline variants on tumor mutation burden and mutational signatures activity

Site-specific validation of the GRANT model for renal cell carcinoma (RCC) cancer-specific survival (CSS) after surgery

Radiomics-based classification of tumour subtypes in breast cancer using MRI imaging

IRE1 signalinig in Triple Negative Breast Cancer

The Monocyte/Hemoglobin Ratio as a New Prognostic Biomarker in Patients with Advanced Pancreatic Adenocarcinoma

miRNAs in Serum and Extracellular Vesicles as Potential Biomarkers of Metastatic Disease in Clear Cell Renal Cell Carcinoma

Immunohistochemistry expression of HER2, Ki-67, and Sialyl-Tn as biomarkers of poor prognosis from patients with gastric adenocarcinoma in Southeastern Mexico.

Genome-scale cell-free DNA methylation analysis for early detection and monitoring of lung cancer

Assessing the potential of specific Tubulin post-translational modifications as predictive biomarkers for taxane response in breast cancer.

Developing a Targeted Plasma DNA Methylation Panel for Early Prostate Cancer Detection

Predictive Signature of Response to Neoadjuvant Chemotherapy Based on Tumor-Educated Platelet mRNA Profiles in Muscle-Invasive Bladder Cancer

Do small extracellular vesicles within serum of different thyroid pathologies express the same miRNA as those isolated from tissue-on-chip?

STRN4/Zinedin is a favourable prognostic indicator for patents with colon cancer

CHI3L1 and CHI3L2 gene and protein expression in colorectal cancer

The Impact of Circulating Malignant Tumour Cells on Tumour Recurrence in Oral Squamous Cell Carcinoma

Prognostic Potential of ctDNA Methylation in Prostate Cancer: Predicting Biochemical Recurrence and Overall Survival in Localized and Metastatic Disease

Identification of Histopathological and Molecular alterations associated with High-risk Oral leukoplakia: A prospective study

Tumor educated platelets in diagnostics and monitoring of childhood brain tumors

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in ascitic fluid as a potential biomarker for Ovarian Cancer development and recurrence

Proteomic profiling of bladder cancer patients-derived extracellular vesicles

Surface plasmon resonance for the detection of EGFRvIII in circulating extracellular vesicles from glioblastoma

Advancing Multi-Cancer Early Detection: High-Performance cell-free RNA Profiling with the Flomics Liquid Biopsy Platform

Bridging Redox Biology and Immune Infiltrates for a Better Understanding of HER2+ Breast Cancer Outcomes

Age and Microenvironment Matter: When Survivin Becomes a Predictor of Poor Outcomes in Neuroblastoma

Biomarkers for neo-adjuvant treatment in locally advanced rectal cancer: preliminary results from a comprehensive characterization of the biological features of good and poor response

Sex-Based Differences in Colorectal Cancer Patients: a Multi-Omics Perspective on Primary and Surrogate Tissues

AKT3 as a candidate biomarker of platinum response in epithelial ovarian cancers

Development of tumor-specific EV-miRNA signatures to improve lung cancer early detection (EV-miR-Test)

Unraveling the Impact of Genetic Ancestry on Breast Cancer Neoadjuvant Chemotherapy Response: A Comprehensive Analysis

Exploring cfDNA copy number profiles to characterize disease stages in pancreatic adenocarcinoma

Investigation of miRNAs expression in Bulgarian patients with early-stage and advanced laryngeal cancer as a prognostic biomarker

Novel Blood-Based mRNA Biomarkers: A Promising Approach for Non-Invasive Colorectal Cancer Screening

What Drives the Expansion of Mutant Clones in Non-Malignant Gastrointestinal Tissues, and How Is This Related to Cancer Initiation?

Investigating the sheddase (s) responsible for HAI-1 ectodomain release in bladder cancer cell lines

Osteosarcoma biomarker discovery in plasma extracellular vesicles using a targeted proteomics approach

Exosomal miRNAs in Breast Cancer cancerogenesis: the EsomiR Study Update

Prognostic value of tumour-infiltrating immune cells in patients with nasopharyngeal carcinoma

The potential diagnostic value of a circulating serum-derived miRNA-based model in patients with colorectal cancer.

Feasibility of tracking multiple primary cancers (MPCs) using tumor-informed circulating tumor DNA (ctDNA) assays

Computational screening for promising protein biomarkers and predictive performance evaluation for lung cancer

Identification of novel diagnostic biomarkers as therapeutic targets in prostate cancer

Multi-omics Approaches to Uncover Liquid-Based Cancer-Predicting Biomarkers in Lynch Syndrome

Virome-based Biomarkers for Non-Invasive Colorectal Cancer Screening

Genomic diversity and BCL9L mutational status in CTC pools predict overall survival in metastatic colorectal cancer

Xenograft derived from circulating tumor cells as a model for preclinical research

Non-invasive bladder cancer detection: identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning

Photodynamic laser therapy decreases inflammation in oral lichen planus patients

Expression of GSK3β and S6K1 mRNA in triple negative breast cancer

Mutational enrichment of CTCs and CTC clusters from breast cancer xenografts

Activated CD4+ T cells as prognostic and predictive biomarkers in cutaneous melanoma

Characterization and evaluation of CD24 and NPY as biomarkers for metastatic castration-resistant prostate cancer (mCRPC)

Tissue Factor (TF) and Factor VII/TF Ratio (fVIIa:TF ) as Potential Indicators of Malignancy in Pancreatic Cystic Lesions

Morphometric analysis of neoplastic cell clusters in high-grade serous ovarian cancer ascites may prove to be a novel prognostic factor: a retrospective study

miRNAs as biomarkers of PARP inhibitors resistance in ovarian Patient-Derived Tumor Organoids

Development of novel biomarker-based methods for early detection of cancer aggressiveness and cancer treatment stratification in Head and neck squamous cell carcinoma.

Unveiling the Role of EVs-derived miR-15b-5p, -1293, -376a-3p in Clear Cell Renal Cell Carcinoma Progression

Advanced detection of targetable gene-drivers: tracking ctDNA changes using digital PCR in liquid biopsies of advanced non-small cell lung cancer (NSCLC)

Performance of a novel NGS-based technology for mutation profiling in liquid biopsies derived from metastatic colorectal cancer patients

Machine learning-driven Integration of bulk transcriptomics and spatial analysis for prognostic stratification in unresectable high-grade serous tubo-ovarian cancer

Detection of Aggressive Prostate Cancer in Urine by Fragment-Level DNA Methylation

A Novel Multimodal Liquid Biopsy workflow for the characterization of Circulating Tumor Cells in Metastatic Breast Cancer

Identification of outcome-associated tumor perivascular features in renal cell carcinoma

UHRF1 role in the repression of Embryonic Morphogenesis genes predicts better prognosis and improves clinical and molecular classification in gastric cancer

Pre-cancer MicroRNA Profile of Normal Tissues Adjacent to Tumor (NAT) in HER2-positive Subtype of Breast Cancer.

Genome-wide DNA methylation profiling reveals a novel DNA methylation signature for early detection of oral cancer using saliva based liquid biopsy

Influence of opioid analgesia, opioid and cannabinoid receptors expression in tumor tissue on survival of patients with pancreatic cancer

Exploiting the heterogeneity of Tumour-derived Extracellular Vesicles in breast cancer to establish proteomic signatures as prognostic biomarkers in liquid biopsies

Deciphering the Potential of Liquid Biopsies Based on Circulating Cell-Free DNA as a Biomarker for Head and Neck Cancer Management

Unraveling Extracellular Vesicle MicroRNA Signatures as Novel Biomarkers and Therapeutic Targets in Sarcopenic Hepatocellular Carcinoma

Comparative Analysis of Technologies for Circulating Tumor Cell Capture, Purity, and Survival: A Comprehensive Evaluation

Proteomic quantification of receptor tyrosine kinases in small intestine, colon, appendix and peritoneum tumours

Unraveling Novel Metastasis Biomarkers: Liquid Biopsy to Guide Treatment Decision in Colorectal Cancer

The role of SLC7A9 in inducing ferroptosis resistance in colorectal cancer

Innovation and Optimization of Surgical Treatment Strategies for Gliomas

Comprehensive bioinformatics analysis DNA damage repair gene with prognosis and immune response in Lung adenocarcinoma

How to kill your fibroblasts and save the cancer stem cells in your culture

The role of integrin β1 phosphorylation dynamics during breast cancer invasion

Novel applications of senolytics to prevent treatment resistance in cervical cancer

Carboplatin-induced transcriptional landscape and growth morphology of ovarian cancer cell models growing in 3D stem-cells supporting environment

Progesterone receptor plays pivotal roles in regulating mitochondria function and mitochondria mediated caspase-independent apoptosis in breast cancer cells

Short-term fasting and zinc ionophores cooperate to promote ferroptosis in colorectal cancer

Can transient inactivation replace loss of the wildtype tumor suppressor as the second hit for colorectal cancer initiation?

PTX3 Promotes Tumor Cell Migration Through the miR-1255b/CYP2J2 Axis in Oral Cancer

Sequential Targeting of IAP and BCL-2 Family Proteins May Enhance Apoptotic Sensitivity in Non-Small Cell Lung Cancer

Treatment with 3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia

A novel role of Kinesin Family Member 20A (KIF20A) in Hepatocellular carcinoma cell metabolism and ferroptosis

Cingulin expression and clinical/prognostic value in breast cancer

SPINT2 Expression in Cancer: Focus on Its Role and Therapeutic Impact in BRAF-Mutated Melanoma

The Role of ADAMTS1 in Oral Squamous Cell Carcinoma: Impact on Invasion, Lymph Node Metastasis, and Prognosis via the ADAMTS1-L1CAM-EGFR Signaling Axis

Exploiting Cellular Senescence to Enhance Precision Oncolytic Immunotherapy

Fuelling the fight: The Impact of a Ketogenic Diet on Chemotherapy-induced DNA damage in Acute Leukemia

High levels of DNA replication initiation factors lead to ATRi sensitivity via excessive origin firing

LAMP1, LAMP2 and LAMP2A IN COLORECTAL CANCER: POTENTIAL PROGNOSTIC BIOMARKERS?

The DC6-KSP signaling Pathway is essentially required for Metabolic Adaptation and Leukemic Progression

Understanding the interplay of EPHA2 and CD44 in colorectal cancer stemness, EMT and therapy resistance.

Role of mast cells in promoting breast cancer stem-like properties via heparanase and MUC1/estrogen receptor axis

TRIB2 overexpression impairs autophagy flux and compromises efficient clearance of cellular cargo

Combined oncogene and pyruvate dehydrogenase kinase inhibition enhances tumor response in resistant NSCLC cells

Polycomb Complex Protein PHC3 Coordinates with HOTAIR Pathway to Promote Colorectal Cancer Progression

Identification and Functional Characterization of Theranostic Biomarkers in Pancreatic Ductal Adenocarcinoma

The protooncogene SETDB1 affects microtubule dynamics through HDAC6

Impact of the E2F1-BASP1 complex on regulating MYC expression

PARP12 as a Novel Therapeutic Target in Breast Cancer: Integrating ADP-Ribosylation, DNA Damage Response, and Hormone Therapy Resistance

Investigating the Cell of Origin in Merkel Cell Carcinoma Using a Human Pluripotent Stem Cell-derived Model

Aldehyde metabolism as a target for metastatic melanoma

The TMBIM4 Golgi Apparatus Ion Channel Supports Cancer Cell Survival by Altering Cysteine Availability

Role of the collagen hydroxylase LEPRE-1 in breast cancer

SMALL EXTRACELLULAR VESICLE-DRIVEN FERROPTOSIS: A NOVEL STRATEGY TO TARGET THERAPY-RESISTANT OVARIAN CANCER

Triple-negative breast cancer cell survival strategies under acute and chronic hypoxia

Therapy-resistance of TP53 mutated cancers overcomes by targeting BIRC5 dependency

Metabolic rewiring in the therapy-induced secretome facilitate glioblastoma resistance to radiotherapy

Inhibition of arginase-2 differentially affects cell proliferation in breast cancer cell lines representing different clinical subtypes in vitro.

Macrophages stimulate glioblastoma motility and invasion through paracrine signaling leading to the regulation of Rho GTPases

PD-L1 expression is essential for EGFR signaling- and fatty acid-enhanced metastasis in head and neck cancer

GATA4 drives metaplasia and cancer initiation from foregut keratinocytes in vivo

Generation of a monoclonal antibody anti CD36 for anti cancerous immunotherapies mediated by natural killer cells

Deciphering the role of MET/NMDAR complex in colorectal cancer pathogenesis

Characterizing the partial epithelial-mesenchymal transition and invasion in a colorectal cancer in vitro model

p140Cap-mediated reduction of the stem cell pool enhances breast cancer chemosensitivity

DNA methylation landscape defines metastatic routes in high grade serous carcinoma

Autophagic Cell Death in GBM Cells Following Arginine Deprivation is Mediated by Ferroptosis

The Potential Role of PAK4 in PDGF-BB-Mediated EMT and Metastatic Processes in Triple Negative Breast Cancer

PSMG2 role in tumorigenesis and stemness mediated by protein accumulation, reticulum stress and autophagy.

PP2A inhibitor proteins CIP2A and PME-1 as medulloblastoma oncoproteins and therapy targets.

Age-associated mitochondrial dysfunction drives CAR-T cell failure

Characteristics and Effects of Stemness Genes in Primary and Recurrent Ovarian Cancers and Ovarian Cancer Stem Cells

Oncogenic variants in GNAQ and GNA11 cause dysregulation of calcium signalling in uveal melanoma

Patient-derived organoid models to investigate the role of tryptophan in colorectal cancer progression

Modelling multiple FGFR1 mutations uncovers modulatory effects and novel tumorigenic mechanisms in glioneuronal tumors.

Mevalonate Pathway Suppresses Ferroptosis and Promotes Liver Cancer via CoQ10 Production and Selenocysteine-tRNA Modification

ROBO receptors act as tumor suppressors in cholangiocarcinoma

Effects of Asparaginase-induced amino acids deprivation on Triple Negative Breast Cancer cell lines

Proteo-transcriptomic characterization of the CD14-CD34+ stem and progenitor cells in chronic myeloid leukemia

Spastin Functions in Glioblastoma Multiforme Migration Through Focal Adhesion Kinase Signaling Pathway

DDB2-PCNA interaction is involved in maintaining genome stability in human UV-irradiated cells

The BASP1 signaling protein interferes with the WNT signaling pathway

The Golgi Apparatus Protein TMBIM4 Promotes Glioma Cell Invasion and Metabolic Adaptation

RECREATING A METASTATIC LIVER MODEL TO UNVEIL THE ROLE OF CANCER STEM CELLS IN PANCREATIC DUCTAL ADENOCARCINOMA PROGRESSION AND THERAPEUTIC TARGETING

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

NGFR-Driven Lipid Metabolic Reprogramming in CR-CSCs: Implications for Chemoresistance in Colon Cancer

C/EBPα coordinates key metabolic pathways driving the resistance to targeted therapies in FLT3-mutated acute myeloid leukemia

Impact of prevalent KRAS mutations in PDAC resistance to FIRINOX.

Unbiased Phosphoproteomic and Metabolic Profiling in WT and KRAS Mutant Colorectal Cancer Cells Reveals Molecular Interplay Between Protein Regulation and Metabolic Rewiring

Evaluation of novel, high-affinity SSTR2/SSTR5 somatostatin analogs in pancreatic and pituitary neuroendocrine tumor models.

CK2α and CHIP crosstalk: uncovering its role in tumorigenic processes

Investigating the role of PTX3 in the biology of glioblastoma

Attaching to and Crossing Endothelial Barriers

Nucleotide imbalance sensed by p53 leads to an upregulation of pyrimidine salvage transporter hCNT1

Evaluation of Anti-Cancer Effects of Omeprazole in Prostate Cancer Cells

Therapy-induced senescence shapes tumor biology and treatment outcome in hepatoblastoma

Highlighting the Small GTPase RhoA as a New Therapeutic Target in ALK+ ALCL

Deciphering the Role of CMA in Platinum Resistance: The Impact of LAMP2A in OCCC

Modulation of SUMOylation machinery complex proteins induces cell death in human colorectal cancer cells

α-Mangostin as a potential adjuvant in HER2+ breast cancer treatment

Vemurafenib impairs mitochondrial bioenergetics and modulates stress-related transcript levels in the RAB-1 cell line: a multidisciplinary perspective in translational medicine for histiocytic lesions

Aurora-A-mediated Maf1 phosphorylation plays a novel role by regulating mitochondrial function in hepatocellular carcinoma

INCREASED INTRACELLULAR HYDROGEN SULFIDE PRODUCTION REDUCES CHEMICALLY-INDUCED HEPATOCARCINOMA PROGRESSION AND EXTENDS LIFESPAN IN MICE.

The role of CEMIP and CTCF in castration-resistant prostate cancer: A novel insight from 3D spheroid model

The mTORC2-AKT-GSK3-FBXW7 Axis Regulates ELP1 Stability and U34 tRNA Modifications in Lung Cancer

PRKCz benefits melanoma brain metastases

TGF-β Resistance as a Collateral Mechanism to Senescence Escape and Tumor Aggressiveness in Hepatocellular Carcinoma

C6ORF15 is a driver of lymph node metastasis through upregulation of EMT in colorectal cancer

Tackling oxidative phosphorylation of glioblastoma-initiating cells by specifically impairing 1 transmembrane Chloride Intracellular Channel 1

Unraveling CIP2A’s impact on DNA damage response in basal- like triple-negative breast cancer

MyomiR-133b suppresses colorectal cancer cell proliferation and modulates expression of multiple gene targets

Identifying the role of PLEKHS1 in cancer

Miro1 depletion modulates intracellular ATP distribution and adhesion dynamics, suppressing cell migration and metastasis in B16 melanoma cells

Flow-Based Cell Deformation Reveals EMT-Driven Mechanical Phenotype Changes in Metastatic Prostate Cancer

The Role of Brown Adipose Tissue in Pancreatic Cancer Progression

Cell-free DNA (cfDNA) regulates metabolic remodeling influencing cancer cell proliferation, quiescence, and chemoresistance

Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States and Evolution

Mitochondrial damage triggers therapy-induced senescence

Endothelial pyrimidine synthesis restricts tumor growth

Targeting Tumor Metabolism to Prevent the Development of Resistance to Cisplatin in Ovarian Cancer

Utilizing BioID to Identify Interaction Partners of Haspin Kinase

Characterization of Cancer Stem Cells in Osteosarcoma Progression

The long non-coding RNA H19 promotes cell proliferation, migration, and invasion in breast cancer through the H19/miR-X/BST2 axis

Investigating the role of miR-500 in metastasis-related processes in LLC1 cells

IDH1 mutation induces differential DNA repair and metabolic profiles in glioma

Hypoxia-Driven Fatty Acid Metabolism Regulates Angiogenesis in Gastrointestinal Cancers

The Oncofetal Protein ROR1 Drives Cancer Stemness and Metastasis in Hepatocellular Carcinoma through Actin Cytoskeleton Remodelling

Unraveling the PKM2 Nexus: Metabolic Reprogramming, Nuclear Regulator, and p38 MAPK-Signaling Driven Drug Resistance in Colorectal Cancer

Assessing the impact of endolysosomal Two-pore channel 2 (TPC2) on malignant melanoma aggressiveness

The SuSe Model: A Dual-Marker Approach to Investigate the Impact of Senolytic Therapy in Cancer

Dual-targeted therapy: Novel interventions to inhibit metastasis and chemoresistance in cervical cancer

Novel molecular insights of gastric cancer dissemination and prognosis

Epigenetic and Metabolic Consequences of JMJD5 Loss in Hepatocellular Carcinoma

Nuclear receptor NR5A2 negatively regulates HIF-1alpha signaling to inhibit tumor-specific metabolic adaptations in glioblastoma cells: potential novel therapeutic implications via NR5A2 targeting

In vitro tranformation of primary uveal melanocyte into uveal melanoma.

Exploiting senolytic drugs to strike brain tumors metabolic vulnerabilities

Therapeutic overactivation of oncogenic signaling to improve outcomes in Ewing sarcoma

The Androgen Receptor Mediates Immune Evasion and Progression of Melanoma

Inflammatory secretome from triple negative breast cancer cells drives EMT and enhances migration in non-cancerous breast cells

Synergistic cell cycle blockade with the combination of CDK4/6 PROTACs and a CDK2 inhibitor as a potential anticancer strategy

Induction of ferroptosis and senescence in epithelial ovarian cancer cell line: Implications of targeted therapeutic strategies

Investigating the relationship between IGF signalling, androgens and amyloid precursor protein (APP) processing in prostate cancer

Targeting endometrial cancer stem cells with an ALDH-mediated photodynamic therapy

MBNL1 as regulator of doxorubicin resistance in triple negative breast cancer

Translational control of BRAF and NRAS oncogene-driven MAPK signaling in malignant melanoma

Metabolic Reprogramming and Phenotypic Adaptation in Colorectal Cancer Cells Exposed to a Hypertrophic Adipose Microenvironment

Role of MRPL15 in mitochondrial dynamics, cell cycle, and EMT regulation in different breast cancer subtypes. Implications for tumor progression.

ABCC1 is responsible for invasive phenotype development in colon cancer

Role of the NEDD4 family of E3 ubiquitin ligases in regulating the size of connexin43-based gap junctions in cervical cancer cells

tRNA Optimality Shapes Colorectal Cancer Stem Cell Identity Through Regulation of mRNA Translation

AMPK as a regulator of glioblastoma invasion and cytoskeleton dynamics

The Transcription Factor SNAI2 as a Novel Mediator of EWS-WT1 (+KTS) Oncogenic Activity in Desmoplastic Small Round Cell Tumour

Asparagine-driven transsulfuration compensates for malate-aspartate shuttle deficiency in tumor growth

Divergent Effects of Tet2- and Dnmt3a-mutant Clonal Hematopoiesis on Breast Cancer Progression Upon Aging

IL-2/STAT5 signalling drives metabolic reprogramming to support cervical cancer cell proliferation

HiBiT-Tagged CRISPR Cell Line Engineering: Enabling Antibody-Free Protein Quantification and Targeted Degradation Analysis in Cancer Research

Cancer associated fibroblasts regulate breast cancer migration through Laminin-511

PPP2R2B-derived circRNA in the suppression of ferroptosis in Pancreatic cancer cells

A20: a potential target to boost immune checkpoint blockade in EGFR driven lung tumors

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

Genes that affect DNA repair and calcium metabolism predispose to Malignant Mesothelioma

Genome-wide CRISPR Screening in Embryonic Stem Cells Identifies Synthetic Lethality Interactions in MLH1 and TP53 Deficient Tumors

The use of ultra-low-pass sequencing data to classify tumors' molecular deficiencies

Whole-genome CRISPR-Cas9 screens identify SHOC2 as a genetic dependency in NRAS-mutant melanoma

Molecular Evolution of Driver Mutations in Cancer with Microsatellite Instability and Their Impact on Tumor Progression: Implications for Precision Medicine in Patients with UCEC

Spatial proteomic profiling of tumor microenvironment dynamics in ER-positive breast cancer

Advancing Biobanking in Europe to foster Cancer Research

Integrative Analysis Reveals RNF135 as a Prognostic and Immunological Biomarker in Glioblastoma

Functional diversity of the TP53 mutational landscape revealed by saturating genome editing

Genetic Profiling of Homologous Recombination Repair Pathway Alterations in Ovarian Cancer patients’ cohort from Serbia

Single-Cell Multi-omics with InTraSeq Uncovers Novel Insights into Th17 Differentiation

Distinct Mutational Profiles in Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma Compared to de novo Cholangiocarcinoma

Massively scalable direct guide RNA capture for pooled CRISPR screening

Different mutational patterns in primary colorectal cancer and its paired synchronous or metachronous metastasis and their association with patient outcomes

Saturation mutagenesis of the FGFR kinase domains reveals all activating point mutations and their drug response

Arm-level somatic copy number alterations in liver metastases of colorectal carcinoma associated with time to relapse after surgical resection

Genomic instability and mitochondrial dysfunction drive high grade serous ovarian cancer

“Hello from the other side” – Exploring the interplay between cancer cell metabolism and immune cells in Ductal Carcinoma In Situ (DCIS)

Investigating the molecular diversity of luminal breast cancer arising in young women

KRAS mutation derived PSMB8 activates MEK/ERK signaling to promote chemoresistance in pancreatic adenocarcinoma

Analysis and machine-learning based prediction of cellular adaptation during ovarian cancer treatment.

Single-Cell Analysis Reveals U1 snRNA Mutation–Driven Tumor Microenvironment Remodeling in Chronic Lymphocytic Leukemia via CD44 Signaling

Investigating Topoisomerase IIβ Binding Protein 1 as a Potential Prognostic Biomarker and Therapeutic Target in Bladder Cancer

Origin of chromosomal instability during acinar to ductal metaplasia in pancreatic cancer

Method Development of Single Cell Readable Stress Signal Recording System

Isoform Switching in Different Grades of Non-Muscle Invasive Bladder Cancer (NMIBC): Changes in Gene Function without Changes in Gene Expression

Identifying immune cell phenotypes and their function by using high throughput spatial multiomics

Genome-scale screenings identify determinants of sensitivity of cancer cells and tumors to NFYA inhibition

Putative Novel Breast Cancer Genetic Drivers in Ghana: Insights from a Cohort Study

Decoding atypical teratoid rhabdoid tumor subtype-specificity: single cell aspect of differentiation trajectories and potential maturation therapy

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

The computational strategy, popmax, decreases misclassification of germline variants

Comprehensive analysis of somatic structural variations in Malignant pleural mesothelioma (MPM) using long-read sequencing

Dependency-Shock transcriptomic footprints as predictive tools in early anti-cancer drug discovery

Combined analysis of chromatin accessibility, promoter interactions and whole genome sequencing solved the missing heritability in gastric cancer

BUB1-Mediated G2/M Checkpoint Control and Mitotic Integrity: A Targetable Vulnerability in MPM

Illumina based ex situ whole transcriptome workflow providing large area capture substrate, up to 7.5 cm2 active area, and a scalable end-to-end software solution

A defined genomics approach for delineating the cellular states during pancreatic cancer initiation

Screening and functional characterization of small molecule compounds with selective cytotoxicity in Anaplastic Thyroid Carcinoma

Whole-genome sequencing of 122 upper urinary tract urothelial carcinomas.

DNA Methylation and Structural Variants in Breast Cancer: A Nanopore Sequencing Approach

Prometastatic gene signatures of conventional and serrated colorectal carcinoma and their regulation by microenvironmental factors from primary and metastatic sites

Long-Read Resequencing of Acute Myeloid Leukaemia Single-Cell RNA Sequencing Samples Improves Detection of Malignant Genomic Alterations

Mapping immune responses to 90 cytokines in PBMCs with a 10 million cell atlas using high-throughput combinatorial single cell RNA sequencing

Transforming AI-Driven Drug Discovery with a 100 Million Single-Cell Dataset

Towards an Quantitative Phenotypic Progression Model of Prostate Cancer

Molecular Profiling of Brain Metastases from Distinct Primary Tumors Identifies Subtypes with Implications for Therapy and Biomarker Development.

Single-cell CRISPR screens: a comparative evaluation of droplet-based and combinatorial split-pool barcoding platforms

Exploring Alternative Splicing in Breast Cancer: Direct RNA Nanopore Sequencing for Transcriptome Profiling

Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma

Molecular Characterisation of Trophoblast Tumours

Clinical and Genetic Heterogeneity in Early-Onset Colorectal Cancer: Unclosing Distinct Molecular Entities

Multimodal analysis of spatial transcriptomics data uncovers novel invasive lobular carcinoma subtypes

Late effect of radiotherapy: impairment of DNA double-strand break repair mechanisms in skin and lung fibroblast of previously irradiated sheep

Secreted clusterin promotes the migration and invasion of triple-negative breast cancer cells

Biological relevance of the long non-coding RNA NEAT1 in Squamous Cell Carcinoma progression

The landscape of somatic mutations in Hepatitis B virus-infected livers and its role in the origins of liver carcinogenesis

Notch signaling during G2 Damage Checkpoint: a multifaced node to overcome drug resistance in T-cell acute lymphoblastic leukemia (T-ALL)

The Role of YWHAG Silencing in Reducing Proliferation and Migration in Glioblastoma

Partial inactivation of VPS34 combined with oncogenic KRAS accelerates pancreatic cancer initiation and mimics early metastasis dissemination

Effect of exposures to cancer risk factors on the clonal structure of normal kidney tubules

VPS34-driven autophagy permits cell plasticity and cancer initiation

Use of the novel cell division assay (CDA) to evaluate T cell toxicity in response to lutetium-177–DOTATATE peptide receptor radionuclide therapy

Genomic Landscape of Skin and Internal Cancers in Xeroderma Pigmentosum Patients Reveals Signatures of Nucleotide Excision Repair Deficiency

Secretome profiling of TNBC cells under an inflammatory condition enhances tumorigenic properties in non-tumoral breast epithelial cells

Adquired resistance mechanisms to KRAS G12C inhibitors in lung cancer

Novel Topoisomerase I (Topo1) inhibitors with a non-Camptothecin core scaffold to overcome resistance to current Topo1-targeted drugs and ADCs

Chemotherapeutic Response and Resistance in a 3D MDA-MB 231Triple-Negative Breast Cancer Spheroid Model

Overcoming Gemcitabine Resistance in MDA-MB-231 Cells: A Synergistic Approach Using ABT-737 and NVP-BEZ235 Dual Inhibition of PI3K/mTOR

Bacterial modulation of 5-FU chemoresistance in head and neck cancer

Investigating AMBRA1’s role as a prognostic biomarker of resistance for melanoma therapies

Variable responses to Akt kinase inhibition stem from non-genetic heterogeneity

Acquisition of resistance to targeted therapies in lung cancer: mechanistic basis and suppressive strategies

BET inhibitor Birabresib synergizes with PARP inhibitor Talazoparib in urothelial cancer cell lines and patient-derived organoids

Activation of the Integrated Stress Response to overcome multidrug resistance in cancer therapy

Targeting DUSP6 to combat therapy resistance and brain metastasis in HER2-positive breast cancer

Understanding and targeting mechanisms of resistance to the cytidine deaminase biodegrader and gemcitabine combination in cancer

KRAS silencing impacts chromatin organization and transcriptional activity in colorectal cancer cells

Characterization of TRIB2 role in pancreatic cancer chemoresistance

Identifying Therapeutic Vulnerabilities in KRASG12D-Resistant Pancreatic Cancer Using High-Throughput Drug Screening

Potential therapeutic implication of Epithelial Protein Lost in Neoplasm (EPLIN) in head and neck cancer and chemotherapy resistance

Combination therapy with YAP/TEAD and RAS inhibitors overcomes phenotypic cell plasticity-driven resistance in NRAS-mutated melanoma

The interplay between mechanisms of resistance and therapeutic targets: identifying novel treatments for drug-resistant BRAFV600E pediatric high-grade glioma

Targeting ErbB receptor family to intercept therapy adaptation in ALK-positive lung cancer

The Role of NRG-1 in Resistance to Targeted Cancer Therapies in ERBB2-Amplified Breast Cancer

Unraveling the Hidden Player: miR-188-5p at the Crossroads of DDR and PARP Inhibitor Resistance in Ovarian Cancer

Decoding drug resistance in cervical cancer cell lines: an AKT-independent mechanism

Rituximab resistance shapes sensitivity to effector-cell mediated cytotoxicity in B-cell lymphoma

Crosstalk between oncogenic signaling pathways as driver of therapy resistance against small molecule inhibitors in Glioblastoma

Targeting Drug Resistance in Hepatocellular Carcinoma: Uncovering Metabolic Vulnerabilities for Therapeutic Re-Sensitization

Investigating estrogen receptor fusion proteins as a mechanism of resistance to endocrine therapies in breast cancer

Increased Sensitivity to BCL-2 Inhibition in EGFR-TKI Resistant NSCLC Cell Lines

SPOCK1 is Linked to Mesenchymal-like Features and Drug Resistance in Melanoma Cells Treated with BRAF and MEK Inhibitors

Combinatorial assessment of DXd-based antibody drug conjugates with DNA damage response inhibitors in ovarian and endometrial cancers

Unraveling Therapeutic Resistance in Patients with Early-Stage HER2-Negative Breast Cancer in the I-SPY2 Clinical Trial

Pt1a and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma effect through RNA m6A methylation modification

SOAT1 Promotes Methotrexate Resistance in Choriocarcinoma

Creating Repotrectinib Resistance in a Ba/F3 SLC34A2-ROS1 NSCLC cell line

Targeting Fascin as a Therapeutic Approach to Overcome Oxaliplatin Resistance in Colorectal Cancer

SRSF9-mediated alternative splicing impairs anti-tumor immunity and drives resistance to PD-L1/VEGF-A blockade in hepatocellular carcinoma

Revealing Distinct Oxaliplatin Resistance Mechanisms in HCT116 Cells Through Genomic and Transcriptomic Analysis Under Continuous and Intermittent Treatment Regimens

An unbiased in vitro screen for uncovering HER2 drug resistance mutations

Quantitative proteomics of drug-metabolizing enzymes and transporters in patients with appendix tumours

Establishment of chemoresistant patient-derived tumor organoids (PDTO) to identify relevant biomarkers for second-line treatments in ovarian cancer

Lysosomal Ca2+ release via TRPML3 enhances drug sensitivity of gefitinib-resistance NSCLS cells

SOS1 inhibition enhances the efficacy of and delays resistance to oncogene-targeted therapies in lung adenocarcinoma

INTRINSIC MECHANISMS OF RESISTANCE TO CDK4/6 INHIBITORS IN LUMINAL METASTATIC BREAST CANCER

Overcoming Antibody-Drug Conjugate Resistance in HER2-Positive Breast Cancer: Insights into Molecular Mechanisms and Targeted Therapeutic Approaches

Chlorpromazine nanoparticles enhance anti-cancer effect of Doxorubicin nanoparticles preventing their extrusion

Involvement of Androgen Receptor/miR-181a-5p/c-Met Axis in the Progression of Prostate Cancer

miR-212-3p Down-Regulates the MAPK/ERK Pathway to Mitigate Oxaliplatin Resistance in Colorectal Cancer

Functional and molecular changes implicated in doxorubicin resistance in breast cancer

Sensitization of ovarian cancers to ΡARΡ inhibitors by inductiοn of an ΗRD phenοtype: towards a medicine of precision based on UBE2Ν inhibitiοn.

A not expected effect of longterm temozolomide treatment on resistance of glioblastoma cells – an in vitro study

Intercellular Communication via Therapy-Induced Secretome Drives Chemoresistance in Ovarian Cancer Cells

On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells.

The Role of AP-1 Target Transcript Vav3.1 in the Regulation of Osimertinib Resistance in Lung Adenocarcinoma

Unravelling PARP inhibitor resistance mechanisms in ovarian cancer

Identifying miR-7-5p/KEAP1/NRF2 and miR-122-5p/ADAM10/IL-6 signaling axes in Castration and Enzalutamide-resistant prostate cancer cells

Targeting ferroptosis resistance by inhibiting SCD1 in TNBC enhances tumor response to immunotherapy.

Tumor microenvironment determines immune resistance to chemoimmunotherapy in KRAS-mutant Non-Small Cell Lung Cancer: transcriptomic insights from a prospective cohort

Targeting BCL-2 proteins as a Strategy Against Therapy Persistency in TNBC

Targeting Epigenetic Mechanisms to Overcome Drug Resistance in TaxaPlatin-Resistant Prostate Cancer

CDK12/13 inhibition can counteract Epithelial Ovarian Cancer chemoresistance

High resolution profiling of complex in vitro 3D lung cancer model to monitor resistance to immune checkpoint inhibitors

EGFR/SHP2-targeted antibody-drug conjugate for colorectal cancer theranostics

Overcoming PARP inhibitor resistance in ovarian cancer: interest of the HDAC inhibitor belinostat

Reducing Glioblastoma Treatment Heterogeneity Through Tumor Treating Fields Application Coupled With tmCLIC1 Impairment by Metformin

Cisplatin resistance hinders the response to CDK4/6 inhibitors in esophageal squamous cell carcinoma cells

Targeting AURKA Overcomes Gemcitabine Resistance in TP53-Mutated Cancers by Disrupting the Replication Stress Response

RASSF1A Methylation and Survival Outcome in Retroperitoneal Leiomyosarcoma

Investigating the influence of copper homeostasis on epigenetic modulation in the tumour microenvironment

Deciphering the epigenetic de-regulation of the stem cell related HOX signature in glioblastoma

Boosting Pancreatic Cancer Treatments: overcome chemoresistance by targeting N6 methyladenosine modification

The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

Defining the Epigenetic Landscape regulating a Progenitor Signature in Development and, during Tumour Initiation and Progression

Identification of epigenetic drivers in colorectal cancer from clinical tissue and blood samples

Multiomics 6-base sequencing enhances the performance of early colorectal cancer detection from cell-free DNA

MicroRNA-Driven Modulation of TACSTD2 (TROP2) in Colorectal Cancer Progression

The CTCF - H3K27 methylation axis supports the migration of melanoma cells by regulating cholesterol biosynthesis

Targeting the chromatin remodeler HELLS to Improve Therapeutic Strategies in T-Cell Lymphoma

Single-Cell Analysis of Epigenetic Landscapes Highlights Recurrent Chromatin Accessibility Alterations in Colorectal Cancer

Epigenetic changes on the X chromosome in chronic lymphocytic leukaemia

Higher global DNA methylation levels in tumoral tissue from Mexican patients with Prostate Cancer with different Gleason score

Glucagon-like Peptide-1 Receptor involvement in breast cancer progression is regulated by epigenetic mechanisms

LACTB Promotes SHMT2 Degradation, Modulating Glycine Metabolism and DNA Methylation Patterns in Breast Cancer Cells

Hsa-miR-200c-3p, hsa-miR-25-3p and hsa-miR-301a-3p as potential biomarkers and therapeutic targets for restoration of PTEN expression in clear cell renal cell carcinoma

Integrated analysis of longitudinal cell-free DNA and matched tumor profiling data to identify novel breast cancer biomarkers

Hypermethylation of extracellular matrix genes in colorectal adenocarcinoma

SUV39H1 regulates cell adhesion of pediatric high-grade gliomas through modulation of β-catenin

Methylation-driven epigenetic regulation of the MIR141 core promoter in bladder cancer short-term progression

Exploiting the tumor-suppressive role of the transcriptional repressor SAMD1 in pancreatic ductal adenocarcinoma

Investigating the tumor-suppressive role of the transcriptional co-repressor IRF2BP2 in pancreatic ductal adenocarcinoma

Preventive and Therapeutic Effects of Amaranthus hybridus and Corchorus olitorius on Breast Cancer

Phage display identified claudin 18.2 binding peptide for early pancreatic diagnosis and tumor-target killing.

Nanobody-PROTACs: Method development towards the use of single-domain antibody proteolysis-targeting chimera constructs (sdAb-PROTACs) to target 'undruggable' proteins for degradation

Impact of immune checkpoint inhibitors (ICIs) alone or combined with chemotherapy (ICI/chemotherapy) on the prognosis of non-small cell lung cancer (NSCLC) patients with high expression of programmed

A potential nanocarrier for Androgen-resistant in prostate cancer: Green synthesis of ZnO nanoparticle

Preclinical Evaluation of RAS(ON) Multi-Selective Inhibitors as a Therapeutic Strategy for KRAS mutant Cholangiocarcinoma

Development and Validation of a Novel Multi-Functional Iron Oxide Nanoparticle for the Targeted Induction of Ferroptosis in Cancer

Innovative Cyclic Peptide Disrupts IL-17RB/MLK4 Interaction for Targeted Pancreatic Cancer Therapy

Rationally designed cholesterol-coated peptide nanosponges as a novel therapeutic strategy in the management of Adrenocortical Carcinoma

Targeting Estrogen-Related Receptor Gamma (ERRγ) in Ovarian Carcinoma: Therapeutic Potential of DN200434 and MK2206 Combination in-vitro and in-vivo

canSERV – providing cutting edge cancer research services across Europe

Targeting PDGFRA in Pediatric High-Grade Gliomas: Insights from Brazilian Preclinical Models

Patient-Derived Glioma Organoids Resist Standard Therapies but Respond to Targeted Inhibition

Combining in silico and in vitro approaches to repurpose candidate drugs for oral squamous cell carcinoma

Glioma Targeting Peptide-Drug Conjugates: Comparative in vitro and in vivo evaluation

Anti-cancer effects of Amiodarone via cell cycle arrest, mitochondrial dysfunction, excessive autophagy, and increased apoptosis in thyroid cancer cells

UD-086 overcomes trastuzumab deruxtecan-resistance and has a best-in-class therapeutic index in MMAE-based antibody drug conjugates

SELECTIVE DEGRADATION OF MLK3 BY NOVEL CEP1347-VHL-02 PROTAC COMPOUND LIMITS ONCOGENIC POTENTIAL OF TNBC

EZH2 inhibitors dramatically sensitize breast cancers to HER2 kinase inhibitors through cooperative effects on YAP and pro-apoptotic regulators

Pre-clinical Evidence for Ivacaftor as a Potential Repurposed Therapy for High-Grade Serous Ovarian Cancer and Endometrial Cancer

Synergistic antineoplastic Effects of Jania rubens Extracts with Conventional Chemotherapy in Colorectal Cancer.

1959-sss/DM4 Antibody-Drug Conjugate targeting extracellular LGALS3BP Exhibits Potent Antitumor Activity in orthotopic Glioblastoma Models

Bufalin Targets Protein Translation and Cell Metabolism to Overcome Therapy Resistance in Melanoma

FAM46C expression sensitizes multiple myeloma cells to PF-543-induced cytotoxicity

An intracellular cytidine deaminase biodegrader to overcome cancer chemoresistance

dTAG-based degradation of CDK5 as a therapeutic strategy in colorectal cancer

Multiomic characterization and high-throughput drug testing of patient-derived NSCLC organoids

Sesquiterpene Lactones Cynaropicrin and Ludartin as Potential Therapeutic Agents in Ovarian Cancer

Unlocking the Therapeutic Potential of Platelets in B-Cell Malignancies – Preliminary Study

Designer proteins to drive the targeted degradation of tankyrase

Alectinib enhances response to RBM39 degradation via SRPK1 inhibition in high-risk neuroblastoma

Targeting MYC as a promising therapeutic strategy for pediatric medulloblastoma

Optimizing Gemcitabine Delivery: HPMA Copolymer Conjugates with Controlled Drug Release and Immunomodulatory Activity

Discovering ERBB signaling as therapeutics target for β-catenin mutation driven hepatocellular carcinoma using mouse organoid platform

CircRNA-mediated inhibition of miRNA-454 as a novel therapeutic strategy in prostate cancer

Preclinical Evaluation of T-DXd and AZD1390 in HER2-Low, Triple-Negative Breast Cancer Models

Reactivating the crosstalk between natural killer and tumour cells in non-small cell lung cancer (NSCLC) patients with no actionable mutations

Harnessing the impacts of a G-quadruplex ligand in liposarcoma: Implications for MDM2 oncogene targeting and DNA damage-mediated immunomodulatory effects

Synthetic Danshen Compound Inhibits Adipogenesis, Promotes Adipocyte Browning, and Induces G1 Cell Cycle Arrest While Suppressing Tumor Cell Migration and Invasion in Prostate Cancer Cells

Investigating BCL3 as a therapeutic target to treat prostate cancer

The RUVBL1/2 Complex: An Actionable Molecular Target in Bladder Cancer

Cold-pressed lingonberry (Vaccinium Vitis-Idaea) extract inhibits proliferation, invasion and glycolysis of oral carcinoma cells

Discovery of a novel 1,2-epoxysteroid oxime with potent anti-pancreatic cancer activity

Unveiling the Therapeutic Potential of Tick Salivary microRNAs in Cancer Treatment

Boronated derivatives with a carborane cage, sulfamido group, and Gd-DOTA for B/Gd-NCT with Carbonic Anhydrase IX inhibition.

Investigating the cytotoxic effects of rhenium (V) complexes with apigenin and derivatives

Arginine deprivation, mTOR signalling and DNA repair response in models of ovarian cancer

Co-targeting of EGFR and Sp1 to inhibit TKIs resistance and improve immune response in NSCLC tumors

Characterisation of bicyclic drug conjugate tool molecules using complementary 2D and 3D cellular models in vitro

Diphyllin, a SPP1/DKK1 inhibitor, restricts hepatocellular carcinoma growth by modulating sugar and bile acid metabolism

Transcriptional profiling and ex vivo drug pre-screen for personalized therapy selection

Remodeling the Tumor Microenvironment through TSP-1/CD47 Antagonization: Non-Clinical Characterization of the TAX2 drug candidate

A Novel High-Throughput Assay for Targeted Protein Degradation: Application to BCL-xL in Cancer Cells

Novel Titanocene-derived complex with high albumin affinity: Evaluation of antitumor activity in ovarian cancer cells

Lysosomal Stress as an Off-target Effect of UNC0642 in Pancreatic Cancer Cells

Development of GD2-Targeted Herpes simplex vectors for OncoVirotherapy

Therapeutic deep eutectic systems as promising selective therapeutic agents in the anticancer battle

Identification and Validation of new In-Silico Designed MYC Binders

Investigation of novel anti-leukemic compounds uncovered through high-throughput screening of human model leukemias

Potential of inhibition of AR to enhance the sensitivity of OVCAR-3 cells to PARP inhibitor

Targeting Invasive Behavior in 2D, 3D, and In Vivo Models with Pentamethinium Salts as Migrastatic Agents

Rhenium Complexes as Promising Selective Anticancer Agents

Mechanism of Action of DNA Polymerase Inhibitors in Triple-negative Breast Cancer Cells and Anti-tumor Effects in an Intraductal Breast Cancer Mouse Model

Targeting RSK1 in Colon Cancer: Discovery and Evaluation of a New Small Molecule Inhibitor

Mitochondrial Transplantation from Oxidatively Stressed Adipocyte-Derived Mitochondria Induces Ferroptosis in Glioblastoma

Patient-Derived 3D metastatic melanoma models for target discovery and personalized therapy

Pan-cancer therapy using oncofetal-chondroitin sulfate targeting antibody-drug-conjugates

EGFR targeting restores primary cilia loss upon ETS-driven oncogenic transformation in prostate cells

Combination of cerium oxide nanoparticles and antimalarial drug chloroquine: characterization and anti-cancer potential for triple negative breast cancer

The role of drug efflux and uptake transporters in the plasma and tissue disposition of KRASG12D inhibitor MRTX1133

Identification of a new ERK5 kinase inhibitor

Dual-Active Peptides: A Promising Therapy for Brain Metastases

Optimization of Bivalent Immunoliposome Preparation for Selective Cytotoxic Activity Against Triple-Negative Breast Cancer Cells

The development of a USP7 inhibitor for cancer immunotherapy

Isolation of anti-proliferative bioactive compounds from Gypsophila erocalyx plant extracts by activity-guided approach and its activity in prostate cancer

Synergistic effect of 5-fluorouracil and the small molecule Wnt/

Identification of HMGA protein inhibitors as potential cancer therapy

Idasanutlin in combination with PD-1 blockade - synergy or antagonism?

Multiparametric Analysis of High-Throughput 3D Imaging-Based Drug Screening Reveals Cancer Drug-Induced Vulnerabilities in Patient-Derived Metastatic Colorectal Cancer Organoids

Celastrol induces pro-apoptotic and anti-migratory effects against medulloblastoma subtypes

Localized Drug Delivery for Cachexia-inducing Tumors: Overcoming Systemic Treatment Challenges

Nanocarriers for Targeted Boron Delivery to Tumor Cells in BNCT Applications

Antitumor immune mechanisms elicited by NLRC5 expression in cancer cells

Preclinical validation of a promising protein-protein interaction peptide inhibitor towards metastatic breast cancer

Development of an optogenetic lytic system in E.coli based on phage-derived lytic proteins as a light-controlled and safe drug delivery platform.

Triptolide induces pro-apoptotic effects against medulloblastoma subtypes

Identifying on-target and off-target effects of hundreds of oncology drugs in PRISM large-scale cell line profiling with machine learning analysis of baseline and functional genomic features

Assessment of novel therapeutic treatments in KRAS mutant Colorectal Cancer using Patient-Derived Organoids

Evaluation in vitro and in vivo of the therapeutic effect of the melatonin-furanochalcone hybrid in colorectal cancer

Anagrelide induced remodeling of the PDE3-SLFN12 interactome provides insights into translation initiation dynamics and molecular glue mechanisms

Antitumoral compounds: a nutraceutical approach in cancer therapy

Comparative analysis of proteomics and transcriptomics in patient-derived tumoroids for precision oncology and drug discovery

Coffee Exosomes Have Distinct Effects on Melanoma and Glioblastoma Cancer Cells via PTEN Tumor Suppressor Protein

Highly-targeted personalised siRNAs for BRAF-fusions inhibit melanocytic proliferation

Evaluation of pleural mesothelioma sensitivity to targeted DNA damage response inhibitors

Preclinical Evaluation of Novel Phosphoinositide 3-Kinase Inhibitors: Antitumor Activity and Toxicity Assessment

Isothiocyanate-derived mercapturic acids potentiate tubulin polymerization inhibitors anticancer activity in urinary bladder cancer models (in vitro and in vivo studies)

Nanobodies against PSMA as the foundation for new tracers for prostate cancer imaging and treatment

Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation

Exercise to boost the immune system and optimise immunotherapy responsiveness in pancreatic cancer

Epigenetic Modulation of CAR-T cells against Group 3 Medulloblastoma

Unveiling interactions between senescent tumor cells and the host immune system - Implications for Senolytic Immunotherapy

Investigating the repurposing potential of immune checkpoint inhibitors to additional cancer patient populations using Mendelian randomisation

Assessing the Potential of Epigenetic Inhibitors to Improve Immunotherapy Response via In Vitro Models

Bacterial Endospores as Antigen Carriers: A Novel Strategy for Cancer Vaccines

Next Generation Protein Characterization of CD19-CAR Signaling Cascades

The effect of STING agonist on lung metastases and immune landscape in murine model of spontaneous breast cancer metastasis

Pioneer Platform: A Novel Biotherapeutic Antibody Discovery Platform

Understanding bystander killing by bispecific monoclonal antibodies

A novel synthetic peptide HS1002 Enhances T Cell-Mediated Antitumor Immunity

Induction of TWIST1-specific antitumor immunity by DNA vaccine encoding a truncated TWIST1 antigen

mRNA Cancer Vaccines: Leveraging Sugar-Functionalized LNPs for Targeted Antitumor Immunity

Characterization of radiolabelled single-domain anti-HER2 antibodies as potential radioimmunotherapeutics for breast cancer

Glycopolymer-Mediated Gene Delivery for Efficient CAR-T Cell Production

Cellular Composition and Dynamics Upon Immunotherapy Correlate with Clinical Response

Redox-Responsive Self-Immolative Nanogels for Cellular Immunotherapies

Development of PD-L1 based cancer vaccine conjugating a novel T cell epitope

Selection and identification of nanobodies against a cancer-testis antigen, placenta-specific protein 1

Patient-derived tumor tissue cultures (PDTTCs) as a new platform for assessing T cell engager efficacy in glioblastoma.

ENO3PEP vaccine enhances chemotherapy efficacy in pancreatic cancer by boosting anti-tumor immunity

Enhanced natural killer cell anti-tumor activity with Erastin mediated ferroptosis and potential therapeutic application in neuroblastoma.

An innovative immune-on-chip platform for studying tumor-immune interactions and evaluating novel immunomodulatory therapies

MicroRNAs humoral and cellular immune response profile to COVID-19 vaccine boost in cancer patients

The immune and metabolic profile in metastatic and early-stage triple negative breast cancer patients treated with immune checkpoint inhibitors.

Exploring CAR-T Cell Killing Dynamics Through Live-Cell Fluorescence Microscopy

Characterization of Different CAR Architectures Harboring the Murine GD2 Binder 14G2a

Cytotoxic ILC-1 cells determine outcome of PD-(L)1 blockade in microsatellite instable cancers

Visualization and quantification of antibody-dependent cellular phagocytosis (ADCP) using a live-cell imaging high-throughput automation system

Distinct chemotherapy regimens differentially modulate the immune landscape of triple-negative breast cancer, with potential impact on combination with immunotherapy

Inhibition of Furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities

A positive crosstalk between chemokine receptor CXCR4 and intrinsic programmed cell death-1 receptor (iPD-1): anti PD-1, nivolumab, impairs CXCL12-induced signaling, proliferation and migration in human colon cancer cells

Combining NK/CAR-NK-based therapy with autophagy inhibition as therapeutic strategy in high-risk medulloblastoma

Anti-IL-7Rα antibodies: a targeted therapy for T-cell Acute Lymphoblastic Leukemia

Improving Triple-Negative Breast Cancer immunogenicity via viral-mediated epigenetic remodeling

Advancing CAR-T clinical development with high-parameter CyTOF technology

Application of Mendelian randomization to appraise causality of the relationship between the gut microbiome and cancer

Malignancies of the small intestine: incidence and trends in a nationwide registry.

Exploring circulating proteins as intermediates between physical activity and cancer risk

Time to diagnosis for ovarian cancer in England: Associations with ‘alternative explanation’ comorbidities and recent menopause

Characterization of the profile of cancer among vulnerable communities at Sanabel Nour in North Lebanon: an NGO setting

Brain Tumors and Neurodegenerative Diseases: What’s the link?

When clinical meets molecular: CTNNA1 germline alterations are associated with hereditary diffuse gastric cancer development

Genetic Insights into Familial Non-Medullary Thyroid Cancer: Whole Exome Sequencing Reveals Potential Susceptibility Genes in a Representative Family

Incidence of chronic medical conditions in adolescent and young adult survivors of hematologic malignancies in California, 2006–2020

Uncovering Missing Heritability in Prostate Cancer: A Functional Genomics Approach Using Allele-Specific Expression

Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development

Subtyping Xeroderma Pigmentosum in Tanzania through blood whole-exome sequencing

A 8-miRNA risk score-based prediction model for liver cancer rupture

Helicobacter pylori screening integrated to occupational health surveillance - the HPOS Study

Assessment of a Fiber-rich Diet in Post-treatment Breast Cancer Survivors

Effects of Immediate Breast Reconstruction on Psychosocial and Sexual Well-Being in Women with Breast Cancer: The Mediating Role of Breast Satisfaction

Dietary differences exist among rural and urban cancer survivors

Intestinal plasma cell senescence as a biomarker for risk prediction of early-onset colorectal carcinogenesis

Association between area-based socioeconomic status and colorectal cancer mortality in England

The role of diet and dietary patterns on colorectal cancer risk, progression and outcomes

The Impact of Prevention in Hereditary Diffuse Gastric Cancer: Clinical and Economic Insights from the EU PREVENTABLE Project

Dissecting ovarian cancer cellular responses to radioimmunotherapy with β- particle and ultra-short range conversion and Auger electron-emitting radionuclides.

Experimental alpha-radioimmunotherapy for tumors that have acquired resistance to antibody therapy

Personalized Tumor Models for Precision RadioTheranostics of Glioblastoma

Radiobiology of Image-Guided Radiotherapy: in vitro Impact of Computed Tomography on the Radiosensitivity of Lung Cancer

Friedreich’s Ataxia and DNA repair: frataxin deficiency can impair DNA damage mechanisms

Tumour Volume Dynamics of Glioblastoma During Radiotherapy on 1.5T Magnetic Resonance Imaging-Linear Accelerator

Ephrin B3 as a Therapeutic Target and Radiosensitizer in Glioblastoma: New Insights

Targeting immune signaling to overcome radioresistance by increasing DNA damage in breast cancer cells

Evaluation of Therapeutic Efficacy of Magnolol Combined with Radiation in Non-small Cell Lung Cancer

Measurement of radiosensitivity in cervical cancer patients, optimalisation of the RILA method

Unsupervised Clustering of Histopathological Images: A Promising Tool for AI-based Profiling of Head and Neck Cancer Xenograft Models

ENHANCING CANCER RADIOTHERAPY EFFICACY USING NanOx, A NOVEL OXYGENATING NANOEMULSION THAT REVERSES TUMOUR HYPOXIA.

Hypoxic tumor cells acquire a cellular quiescence phenotype that protects them against radiation-induced cell death

Targeting Protein Disulfide Isomerases for Radiation Sensitization in Prostate Cancer

111In-Radioconjugates Carrying DNA Intercalators and PSMA Inhibitors for Improved Auger Electron Therapy of Prostate Cancer

EXPLOITING REPLICATION STRESS AS A NOVEL THERAPEUTIC TARGET IN CIC REARRANGED SARCOMAS.

Therapeutic antitumor potential of brachytherapy combined with TLR7 agonist imiquimod

SoxC transcription factors are oncoembryonic regulators of colon development and cancer

Structural characterization of ligand binding to stabilin-2, the Hyaluronic Acid Receptor for Endocytosis (Stab2/HARE).

Receptor-like Tyrosine Kinase as a Promising Therapeutic Target in Pancreatic Cancer: Counteracting Wnt/β-catenin and Sonic Hedgehog/GLI1 Signaling

Self-antigen presentation drives T-cell leukemia development in a TCR transgenic mouse model

Novel interactions of Mixed-Lineage Kinase 4: identifying key binding partners in breast cancer

H19 Non-Coding RNA expression in Bladder Cancer Tissue as a marker of progression and therapy resistance

APRIL-induced feedback loop regulating BCMA expression in Multiple Myeloma

The Serine/Threonine phosphatase POPX2 and its effects on cell mechano-sensing

Characterizing the Transition from Well-Differentiated to Anaplastic Thyroid Cancer Using Digital Spatial Profiling

Histone deacetylase inhibitors (HDACi) downregulate HER2 protein expression in gastric cancer, leading to pronounced HDACi sensitivity in tumor cells with high basal HER2 expression

Protective Role of Thymosin Beta 4 Against Sarcopenia via Regulation of PI3K/Akt/mTOR and NLRP3 Signaling Pathways in C2C12 Myotubes

Generation of an In Vitro Model for the Study of the Aryl Hydrocarbon Receptor Pathway in Adrenocortical Carcinoma Cell

FOSL1 controls chromosomal instability in non-small cell lung cancer (NSCLC) via the β-catenin/TCF4 complex

Wound Healing Analogy in Medulloblastoma Response to Gap Junction Inhibition and Cytotoxic Therapy

The Alcatraz-Strategy: a roadmap to break the connectivity barrier in malignant brain tumours

The extracellular matrix produced by VEGFR2R1032Q altered melanoma cells modifies adhesive and migratory characteristics of endothelial cells

Downregulation of Frizzled-5 in Gastric Cancer: Tumor Suppressor Potential and the Role of Fibroblast-Derived WNT5A

The Impact of IK Deficiency on Cancer-Related Signaling Pathways: Insights from Zebrafish and Cellular Models

The Androgen Receptor-Serum Response Factor Network As a Pharmacological Target in Castration Resistant Prostate Cancer.

11q Loss Meets 17q Gain: Molecular Insights into Neuroblastoma Treatment Resistance

Tissue factor augments TGFβ signaling in cancer cells by modulating receptors dynamics and plasma membrane tension.

The effects of progesterone on the expression and functionality of large-conductance voltage- and Ca2+-activated potassium channels in human glioblastoma cells

SUPT5H influences Cell Identity in Pancreatic Ductal Adenocarcinoma

Differential gene expression in immune and metabolic pathways in right and left normal colonic mucosa from Lynch syndrome carriers.

Distinct Transcriptomic Profiles in Brain Metastases from Lung and Breast Cancer Identify Potential Drug Repurposing Strategies.

Novel insights into CDH1 non-coding regulatory elements: effects on E-Cadherin expression, metastasis, and patient outcomes

Superclustering-induced activation of death receptors using nanopatterned TRAIL-decorated DNA origami nanostructures

CT Scan Identified Sarcopenia and MST and AND/ASPEN Malnutrition Guidelines in Gastrointestinal Cancer Patients

Cardiac Remodelling and Incident Cardiovascular Risk in Haematological Cancer Survivors from the UK Biobank

Genomic Profiling of Colloid Carcinoma of the Pancreas

Harnessing Patient-Derived Organoids to Personalise Chemotherapy for Advanced Gastric Cancer

Targeting PI3K-Akt Signalling Pathway in the Search for Novel Therapeutic Strategies for Treatment Resistant High-Grade Serous Ovarian Cancer

Evaluation of the Therapeutic Efficacy and Immunomodulatory Effects of Iron Oxide-Conjugated Photosensitizer Nanoparticles in Glioblastoma.

Incomplete ovarian function suppression (OFS) in premenopausal patients with oestrogen receptor positive breast cancer receiving GnRH agonists/antagonists whilst being treated with CDK4/6 inhibitors

BR55: Clinical Development of the First Ultrasound Molecular Imaging Agent for angiogenesis

Melting the Iceberg: Nanomedicines Overcoming Stromal Barriers and Recruiting Effector T Cells in Pancreatic Cancer

Tiny Warriors Against Tumors: A Nanovaccine Approach for Melanoma Brain Metastases

Results of a Neuroscience Education Program in Adults with Cancer Pain: A Controlled Clinical Trial

Establishment and Characterization of a Diabetic Sarcopenia Model in Aged Mice: Insights into Metabolic and Muscular Dysfunction

Engineering M13 Bacteriophages for Targeted Sonodynamic Therapy of Cancer

The Impact of Nanoparticle Size on the Enhanced Permeability-Retention Effect in Breast Cancer

Positioning of MS-AP-030 as a clinical candidate in an adjuvant setting to delay metastasis in colorectal cancer

Challenges in the Collection of Biological Samples from the Operating Room - The Champalimaud Foundation Biobank Experience

Deciphering intestinal zonation and its role in tumour initiation, evolution and progression in mouse models of colorectal cancer

Equitable access to Oncology clinical trials in Europe

Rapid laser-based prototyping of microfluidics chips for drug testing on cell cultures

Enhanced Spatial Proteomics: High-Precision Analysis of the Tumor Microenvironment

Patient-derived HER2-positive gastric cancer organoids display differential response to targeted therapies correlating with patients’ outcomes and serving as models to unravel treatment resistance mechanisms

Enhanced photobleaching for fast and highly multiplexed immunofluorescence staining with broad reagent and assay compatibility

Intraductal Carcinoma of the Prostate- A Precursor Lesion?

A controllable and integrated pump system for high-precision microfluidics used for drug testing and cell cultures

A Multiomic and Highly Multiplex Method of Imaging Metabolites, Targeted Proteins and Targeted Transcripts on the Same Lung Cancer Tissue Microarray Using Novel Mass-Tagged Affinity Probes

3D Tumor Spheroids for Assessing Carbon Nanocapsule-Based Neutron Capture Therapy

Imaging Mass Cytometry Detects the True Dynamic Range of Low-Abundance Biomarker Expression in Human Tumors

Expression of SLC27A5, a long chain fatty acid membrane transporter, in clinical breast cancer and the clinical value in assessing the outcome and metastasis

Analysis of Perigallbladder Lymphatic Flow as a Pathway of Gallbladder Cancer Progression

ACSL3-Mediated MUFA Activation Protects Dormant Breast Cancer Cells from Ferroptosis via Fatty Acid Metabolic Reprogramming

Hypoxia tolerance mechanisms in Head and Neck Squamous Cell Carcinoma

Modelling the extracellular matrix to elucidate collagen-mediated alterations in colorectal cancer using 3D patient-derived organoids

Genome-Wide Analysis of Intronic Sequence RNAs associated with Invasive Lobular Breast Cancer

the MYC dependent lncRNA MB3 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway

Characterization Of m6A Regulatory Proteins and Identification Of Target Genes In Invasive Lobular Breast Cancer

Investigation of m1A and m6A Methylations in Metastatic and Non-Metastatic Triple-Negative Breast Cancer Cells

Genome-wide profiling of intronic RNAs in triple-negative ductal breast carcinoma

GTF2A1-AS lncRNA orchestrates cisplatin-induced cell death transitions as a stress response regulator

Identification of Intronic RNAs Involved in Apoptosis

Dose-Dependent Regulatory Effects of Melatonin on miRNA Expression in PANC-1 Pancreatic Cancer Cells

Combined therapy targeting AR and EZH2 restrains the growth of castration resistant prostate cancer by enhancing antitumor T cell response

A multitarget drug as potential candidate for antimetastatic adjuvant therapy

A whole-genome RNAi screen to identify genes required in Flower-mediated cell competition in Drosophila melanogaster

Dichloroacetate modulates tumor cell immunometabolism and inflammation by regulating TNF alpha and nitric oxide in a 4NQO- induced oral carcinoma mouse model

Complement protein C3 from breast cancer-associated fibroblasts as a regulator of the tumor microenvironment

Exploring the role of innervation in thyroid cancer and modulation by therapy-induced senescence

Developmental mosaicism underlying EGFR-mutant lung cancer with multiple primary tumors