Biography
Dr. Pasca di Magliano obtained her PhD at the Institute for Molecular Pathology in Vienna, Austria. She then joined the laboratory of Dr Matthias Hebrok at the University of California, San Francisco, for her postdoctoral training. The Hebrok laboratory studied embryonic signaling pathways in the development and disease of pancreatic islets; Dr Pasca di Magliano’s research branched out to pancreatic cancer, revealing a role for Hedgehog and Wnt signaling in this disease. Dr Pasca di Magliano joined the faculty at the University of Michigan in 2008, raising through the ranks to Full Professor in 2020. Her laboratory studies the role of oncogenic KRAS, the hallmark mutation of pancreatic cancer, in the regulation of the establishment and maintenance of the pancreatic cancer stroma. Her team developed a mouse model of inducible and reversible expression of oncogenic Kras, which they used to interrogate oncogenic addition to KRAS and the crosstalk between immune cells and pancreatic cancer cells. Her work uses using genetically engineered mouse models is complemented by the use of human pancreatic cancer samples to dissect the components of the microenvironment and their reciprocal interactions.
