Francesco Boccalatte Candiolo Cancer Institute Italy

Discover how 3D chromatin organization acts as a master regulator of leukemia biology, learn cutting-edge approaches to profile spatial genome architecture in cancer, and understand how linking chromatin structure to gene expression networks can identify new precision medicine strategies for improving patient outcomes. • Learn how 3D chromatin conformation capture can distinguish leukemia subtypes and pinpoint their cells of origin by mapping lineage-defining regulatory hubs. • Explore how 3D genome profiling uncovers intra‑tumor heterogeneity in T‑ALL, providing new biomarkers to anticipate and monitor therapy response. • See how chromatin interaction matrices expose structural variants and enhancer hijacking events that drive oncogene activation and leukemic transformation.