DomenicoMavilio IRCCS Humanitas Research HospitalItaly

γδ T cells are increasingly recognized for their role in anti-tumor immunity and Vδ1 T cells have been reported as the predominant γδ subset infiltrating the microenvironment of several cancers. However, their contribution in this setting remains unclear and flow cytometry alone has provided limited insights into their functionality. In this symposium, Prof. Domenico Mavilio (IRCCS Humanitas Research Hospital, Milan, Italy) will present how transcriptome and repertoire profiling at bulk and single cell resolution can clarify γδ T-cell states and provide clues on tumor escape mechanisms. By linking transcriptional state, repertoire, and therapeutic response, this work underscores the potent antitumor role of Vδ1 T cells in endometrial cancer and highlights their potential as therapeutic targets to enhance anti–PD-1 checkpoint inhibitor strategies in the future.