EXPERIMENTAL / MOLECULAR THERAPEUTICS, PHARMACOGENOMICS

17/06/2025 10:45 20:00

Poster and Exhibition Hall

Time	Session

10:45 20:00	Chromenone Derivatives as Potential CRM1 Inhibitors for Glioblastoma Therapy P-354 EACR25-0068 Cristiana Mourato Poster Presenter Portugal	IQS080 is a novel cytosolic multitargeted kinase inhibitor that simultaneously targets key kinase families, making it a promising candidate for the treatment of pancreatic cancer P-355 EACR25-0084 Alberto Villanueva Poster Presenter Spain	Engineering Bacteriophages for Targeted Photodynamic Cancer Therapy P-356 EACR25-0086 Alena Kaltenbrunner Poster Presenter Italy	The anthelmintic drug rafoxanide promotes oxidative stress and VDAC1 opening, leading to mitochondrial dysfunction in colorectal cancer cells. P-357 EACR25-0132 Federica Laudisi Poster Presenter Italy	The synergistic effect of sedanolide and 5-fluorouracil on triggering mitochondria-dependent apoptosis in colorectal cancer cells P-358 EACR25-0194 Chih-Chung Wu Poster Presenter Taiwan	The interplay between melatonin and alpha-synuclein on melanoma biomolecular signatures P-359 EACR25-0202 Panagiota S. Filippou Poster Presenter Greece	The anti-cancer activity of novel diazo-derived compounds on triple-negative breast cancer P-360 EACR25-0220 Ayse Busranur Celik Poster Presenter Turkey	Enhanced Efficacy and Targeted Delivery System of a pH-sensitive ARV-825 Nanomedicine for Glioblastoma Treatment P-361 EACR25-0228 HIroaki Kinoh Poster Presenter Japan	A genetic signature predicts the response of aggressive paragangliomas to dual PI3K and CDK4/6 inhibition. P-362 EACR25-0326 Bhargavi Karna Poster Presenter Germany	PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors P-363 EACR25-0410 Ling-hua Meng Poster Presenter China	Oxyresveratrol inhibits the tumorigenesis and metastasis of human HCC cells by targeting the CCDC19/PLK1/CCNB1 pathways P-364 EACR25-0414 Hui-Ling Chiou Poster Presenter Taiwan	Integrative Pharmacogenomics in RCC Tumoroids Uncovers Biomarker-Driven Combination Therapies P-365 EACR25-0450 Tianyi Chen Poster Presenter China	Targeted Delivery of Extracellular Vesicles to Metastatic Breast Cancer Cells Using the Tumor-Targeting Peptide p28 P-366 EACR25-0490 Pedro Gon Poster Presenter Portugal	Modulation of GPR55 and PINK1 in Glioblastoma Multiforme Models by Cannabis sativa and Piper nigrum Metabolites P-367 EACR25-0516 andres david turizo smith Poster Presenter Colombia	Repurposing the antifungal piroctone olamine as a targeted treatment for pancreatic ductal adenocarcinoma P-368 EACR25-0532 Sharon Prince Poster Presenter South Africa	Discovery of DAC-1522, a novel Trop2-targeting degrader-antibody conjugate for precision oncology P-369 EACR25-0618 XUAN ZHANG Poster Presenter China	Punicalagin-mediated suppression of oncogenic properties in ovarian epithelial adenocarcinoma cells P-370 EACR25-0622 Zeeshan Ahmad Bhutta Poster Presenter Korea (Republic of)	Risk and benefit for basket clinical trials in oncology: a systematic review with meta-analysis P-371 EACR25-0640 Karolina Strzebonska Poster Presenter Poland	Exploring the Cytotoxic Potential of Calcite on MCF-7 Cells: A Promising Approach for Breast Cancer Treatment P-372 EACR25-0642 Akansha Kothidar Poster Presenter India	Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects P-373 EACR25-0660 Youhong Hu Poster Presenter China	Investigating the Antitumour Potential of Fucoidan with Everolimus: An in vitro and in vivo Study Focusing on ERα/Akt/mTOR Pathway Suppression P-374 EACR25-0718 Maha Ramadan Amin Abdollah Poster Presenter Egypt	High-Throughput Screening Identifies Novel Small Molecule Inhibitors of ELP3 with Potent Anti-Cancer Activity In Vivo P-374A EACR25-0744 DANIELE CARETTONI Poster Presenter Italy	Novel Tamoxifen Derivatives Suppress Breast Cancer Growth and Alter Cancer-Related Gene Expression P-375 EACR25-0762 Irem Durmaz Sahin Poster Presenter Turkey	A novel ribosome biogenesis inhibitor, PMR-116, displays broad spectrum efficacy in preclinical tumour models P-376 EACR25-0930 Luc Furic Poster Presenter Australia	Nanobiotechnological engineering of M13 bacteriophage for EGFR-targeted theranostics P-377 EACR25-1022 Paolo Emidio Costantini Poster Presenter Italy	KA103, a novel targeted toxin for Head and Neck Cancer P-378 EACR25-1032 Castaneda Zegarra Sergio Miguel Poster Presenter Norway	Evaluation of the antineoplastic effects of imipridone derivatives in prostate cancer: Novel therapeutic opportunities P-379 EACR25-1052 Fatima Ghamlouche Poster Presenter Lebanon	Incorporation of disulfide bond into interleukin-2 for enhancing stability, solubility and therapeutic efficacy P-380 EACR25-1056 Woei-Jer Chuang Poster Presenter Taiwan	In vivo delivery of gemcitabine through HPMA copolymer conjugates: slow drug release kinetics is crucial for potent antitumor activity P-381 EACR25-1060 Marek Kovar Poster Presenter Czech Republic	Zebrafish Avatar-test predicts tumor response to chemotherapy in Breast Cancer: A co-clinical study for personalized medicine P-382 EACR25-1072 Raquel Valente Mendes Poster Presenter Portugal	Effect of RID-A proteins in cachexia and tumor metabolism P-383 EACR25-1110 Marta Fornaro Poster Presenter Italy	Targeting BCKDK to Overcome Paclitaxel Resistance in Breast Cancer: A Novel Therapeutic Approach P-384 EACR25-1112 Gehad Mahmoud Iraqy Mohamed Poster Presenter United Kingdom	Datopotamab deruxtecan plus PARP inhibition is highly synergistic in 2D and 3D ovarian cancer models P-385 EACR25-1144 Luna Stockmann Poster Presenter Ireland	Targeted Treatment of Solid Tumors with BRAF Fusions P-386 EACR25-1186 Joseph Samuel Poster Presenter Canada	Long-term organoids derived from head and neck and ovarian cancer patients closely recapitulate tumor of origin and predict clinical outcome P-387 EACR25-1204 Louis-Bastien Weiswald Poster Presenter France	Assay development for addressing drug resistance mediated by fibroblasts in ER+ breast cancer P-388 EACR25-1242 Elisabet Rodr Poster Presenter Sweden	Anisomelic Acid Suppresses HPV-Driven Tumor Growth with Potential TEAD2 Targeting: Evidence from a Xenograft Model and Proteomics P-389 EACR25-1246 Navid Delshad Poster Presenter Finland	PTPN2/PTPN1 inhibition induces tumor eradication in ALK-positive lymphoma by triggering a combination of ALK-induced oncogenic stress and immune responses P-390 EACR25-1302 Marta Rubin Poster Presenter Italy	The Superior Therapeutic Potential of Curcumin-Loaded Zinc Oxide Nanoparticles Against Bladder Cancer P-391 EACR25-1318 Zahraa Salhab Poster Presenter Lebanon	Biological Basis for the Development of CPL410005 as an Antibody-Drug Conjugate P-392 EACR25-1342 Filip Mitu_a Poster Presenter Poland	HSPGs targeting and multimeric cytotoxic conjugates as a novel PDC strategy against pancreatic cancer P-393 EACR25-1374 Krzysztof Ciura Poster Presenter Poland	Teaching cells the drug uptake – rational modulation of endocytosis for precise delivery of novel HSPGs targeting conjugate into pancreatic cancer cells P-394 EACR25-1376 Aleksandra Chor__ewska Poster Presenter Poland	Expression analysis of CTLA-4, PD-1, and PD-L1 in non-small cell lung cancer patients receiving immunotherapy P-395 EACR25-1378 David Bonnel Poster Presenter	Apoptotic Effects of a Flavone Combination on Brain Metastatic Triple-Negative Breast Cancer Cells P-911 EACR25-1382 María Losada-Echeberría Poster Presenter Spain	Integrating Proximity Ligation Assay for PD1-PDL1 Immunoassay with Multiplex Immunofluorescence Imaging in Urothelial Carcinoma P-397 EACR25-1400 Tony Ullman Poster Presenter Sweden	Type I and II BIR domains as targets for cancer therapy P-398 EACR25-1412 Federica Cossu Poster Presenter Italy	Alpha-1 adrenergic antagonists to sensitize neuroblastoma over isotretinoin theraphy P-399 EACR25-1416 Francesca Broso Poster Presenter Italy	Muscle-invasive bladder cancer organoids as a functional system to address therapy response: Perspective in advancing precision medicine P-400 EACR25-1434 Haiyan Yue Poster Presenter Switzerland	MESOPOROUS SILICA NANOPARTICLES FOR THE SELECTIVE DELIVERY OF DOXORUBICIN TO FOLATE RECEPTOR-EXPRESSING CANCER CELLS P-401 EACR25-1450 Catia MORELLI Poster Presenter Italy	Targeting UBE2N with Novel Non-Covalent Inhibitors: A Drug Discovery Approach to Combat PARPi Resistance in Ovarian Cancer P-402 EACR25-1458 Shafi Ullah Khan Poster Presenter France	Multimodal targeting of Ephrin A2 in solid tumors using bi-cyclic drug conjugates P-403 EACR25-1466 Laura Diaz Gil Poster Presenter United Kingdom	Tackling Hepatocellular Carcinoma with novel PROTAC Degraders of eIF6 P-404 EACR25-1474 Giorgia Tempra Poster Presenter Italy	A titanocene-derivative complexed with a myristic-like aliphatic chain exhibits antitumor activity in cisplatin-resistant models both in vitro and in vivo P-405 EACR25-1484 Marta Guadamillas Poster Presenter Spain	EGFR-STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1-positive prostate cancer P-430 EACR25-1490 Elsa Gomes Paiva Poster Presenter Portugal	Targeting CITK in high-grade brain tumors: a comparison of polypharmacological and specific inhibitors P-406 EACR25-1518 Alessia Ferraro Poster Presenter Italy	Development of Lipid-Based Gene Delivery Systems for CAR T Cell Therapy P-407 EACR25-1520 Margarida Guerreiro Poster Presenter Portugal	Oral liquid crystalline dispersion effect in chemotherapy-induced intestinal mucositis P-408 EACR25-1600 Raquel Silva Ara Poster Presenter Brazil	Microneedle-mediated delivery of Iron Oxide Nanoparticles & Oxaliplatin with immune checkpoint inhibitors for its induction of ferroptosis and immunomodulation in Head and neck squamous cell carcinoma P-409 EACR25-1702 Debabrata Tripathy Poster Presenter India	Targeting RRM2: A Dual Approach to Apoptosis and Cell Cycle Control in Atypical Teratoid Rhabdoid Tumors P-410 EACR25-1710 CHE-CHANG CHANG Poster Presenter Taiwan	ALDH1 Isoform Landscape in Breast Cancer: Advancing Precision Therapies with a Potent ALDH1A3-Selective Inhibitor P-411 EACR25-1764 Andrada Constantinescu Poster Presenter France	AI and physics based methods to design biopharmaceuticals to fight triple-negative breast cancer P-412 EACR25-1772 Catarina Tavares Cavaleiro Poster Presenter Portugal	GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells P-413 EACR25-1780 Lidia Atencia Taboada Poster Presenter Netherlands	Mechanistic Insights into the Uptake, Trafficking, Drug Release, and Cytotoxic Efficacy of 5-FU/Irinotecan-Loaded core@shell Nanoparticles in Colorectal Cancer P-414 EACR25-1788 Dolma Choezom Poster Presenter Germany	A novel gene therapy combination targeting non-small cell lung cancer P-415 EACR25-1814 Nathan Vella Poster Presenter Malta	Organ-on-chip platforms for assessing fasting-driven therapeutic responses in dynamic 3D tumor models P-416 EACR25-1832 SILVIA SCAGLIONE Poster Presenter	Oncofetal Chondroitin Sulfate represents a Target for Antibody Drug-Conjugate therapy of Acute Myeloid Leukemia P-417 EACR25-1836 Joana Mujollari Poster Presenter Denmark	Engineering Subtype-Specific Breast Cancer Models: Decellularized ECM-Based Bioinks for Organoid Culture and Precision Oncology P-418 EACR25-1858 Juan Antonio Marchal Poster Presenter Spain	Targeted drug delivery with erythrocyte-derived nanovesicles in an organ-on-chip tumor model P-419 EACR25-1860 SILVIA SCAGLIONE Poster Presenter	Extracellular Vesicles Loaded with miRNAs Target LCP-1 to Inhibit Tumor Growth and Metastasis in Triple-Negative Breast Cancer P-420 EACR25-1954 Marianna Prokopi Poster Presenter Cyprus	Defining Docetaxel’s Antitumor Effects on Calu3 Lung Cancer Cells Using High-Throughput Live-Cell Imaging P-421 EACR25-1972 Svenja Meiler Poster Presenter	Combination of PARP Inhibitor Olaparib and a Vascular Disrupting Agent Reduces Tumor Growth in a Xenograft Mouse Model of Prostate Cancer P-422 EACR25-1992 Evangelia Sereti Poster Presenter Sweden	Cellular response triggered by anticancer agent, C-2028 in breast cancer cells with different expression of key receptors under normoxia and hypoxia conditions P-423 EACR25-2000 Aleksandra Pa_ka Poster Presenter Poland	Polyoxovanadates with Anti-breast Cancer Activity and Ca2+-ATPase Inhibition Potential P-424 EACR25-2028 Manuel Aureliano Poster Presenter Portugal	Enhancing Therapeutic Efficacy in Patient-Derived Models of Pancreatic Ductal Adenocarcinoma Using Engineered Placental Mesenchymal Stromal Cells P-425 EACR25-2036 Laura Drndakova Poster Presenter Slovakia	Investigation of Novel Duocarmycin Payloads Antibody-Drug Conjugates (ADCs) targeting HER2 for Therapeutic Intervention P-426 EACR25-2066 Enric Arasanz Picher Poster Presenter United Kingdom	Triptonide induces pro-apoptotic effects against medulloblastoma subtypes P-427 EACR25-2084 Marriam Yaqoob Poster Presenter United Kingdom	Doxorubicin and cGAMP-loaded hypoxia-sensitive polymersomes: A strategy for enhanced tumor growth inhibition and reduced systemic toxicity P-428 EACR25-2098 Ryszard Smolarczyk Poster Presenter Poland	The effects of a dual GIP/GLP-1 receptor agonist, Tirzepatide, on the response of prostate cancer cells to therapy P-429 EACR25-2140 Haonan Li Poster Presenter United Kingdom	Exploring Polyoxotungstates as Novel Antitumor Agents for Pancreatic Cancer Therapy P-431 EACR25-2150 Maria Filomena Botelho Poster Presenter Portugal	Investigating the repurposing potential of cardiometabolic and hormonal medications for breast and ovarian cancer treatment using Mendelian randomisation P-432 EACR25-2164 Tessa Bate Poster Presenter United Kingdom	Overcoming Gemcitabine Chemoresistance in PDAC with Nanoparticle-Delivered Active Phosphorylated Gemcitabine P-433 EACR25-2172 Nathalia Ferreira Poster Presenter Germany	Combinations of HDAC and KRAS inhibitors in lung cancer P-434 EACR25-2208 Jingyu Li Poster Presenter Germany	Subcutaneous controlled release of antibodies and antibody-drug-conjugates with zwitterionic chitosan-based hydrogels P-435 EACR25-2248 Guillaume Jacquot Poster Presenter France	Effect of doxorubicin and quercetin combined treatment on osteosarcoma model systems P-436 EACR25-2268 Milena Milivojevic Poster Presenter Serbia	Unlocking the Dual Power of miR-302b in BRCA1 Wild-Type Triple-Negative Breast Cancer: PARP Inhibitor Sensitivity Enhancer and Tumor Microenvironment Shaper P-437 EACR25-2280 Valentina Fogazzi Poster Presenter Italy	Targeted Metabolomics for Early-Onset Colorectal Cancer: Identification of Novel Therapeutic Targets and Biomarker-Driven Treatment Strategies P-910 EACR25-2338 María Losada-Echeberría Poster Presenter Spain	MASLiN as hydrophobic anticancer drug carrier: in vitro activity and in vivo biodistribution P-439 EACR25-2358 Juan Antonio Marchal Poster Presenter Spain	Photodynamic therapy with ring-fused chlorins: a vision-preserving approach for retinoblastoma treatment P-441 EACR25-2362 Mafalda Laranjo Poster Presenter Portugal	Exploring the impact of photodynamic therapy conditioning on endometrial cancer cells P-442 EACR25-2370 Mafalda Laranjo Poster Presenter Portugal	The m6A RNA modification sustains neuroblastoma tumor aggressiveness P-443 EACR25-2388 Denise Sighel Poster Presenter Italy	Evaluation of the effect of novel fascin inhibitors in patient-derived colorectal cancer organoids considering molecular and histological characteristics P-906 EACR25-2400 Marketa Pavlikova Poster Presenter Spain	Cold Atmospheric Plasma as a Potential Strategy to Target the Invasion and Metastasis Hallmark in Breast Cancer P-444 EACR25-2418 Mafalda Laranjo Poster Presenter Portugal	Harnessing DNA repair to enhance therapy efficacy in myeloid leukemia: The impact of chronotherapy P-445 EACR25-2428 Joana Jorge Poster Presenter Portugal	Expression profiles of target genes for approved antibody-drug conjugates in the context of high-grade serous carcinoma P-446 EACR25-2462 Elsi Pauliina P Poster Presenter Finland	Alpha-aminobutyric acid attenuates DEN and diet-induced MASLD/MASH mice model by suppression of oncogenic signalling pathways KRAS, STAT3 via gut microbiome modulation P-447 EACR25-2568 Felicianna Felicianna Poster Presenter Hong Kong, China	Combined siRNA targeting of oncogenic NRAS and BRAF drivers as a strategy for mole reversal and melanoma prevention P-447A EACR25-15870 Phoebe Antonia Jones Poster Presenter United Kingdom