dos Santos DiasMatheus Netherlands Cancer InstituteThe Netherlands

Cancer Researchers to watch - An early career showcase

Time	Session

16:10 17:40	Cancer Researchers to watch - An early career showcase (Separate pre-registration required) JacquemetGuillaume Chair Finland Reprogramming immunosuppressive tumor-associated macrophages potentiates standard-of-care therapy in melanoma TichetMelanie Speaker Switzerland Proffered Paper 3: SoxC transcription factors are oncoembryonic regulators of colon development and cancer DalessiTosca Presenter Switzerland Proffered Paper 4: Erythrocyte-derived sphingosine-1-phosphate promotes tumor cell survival in the circulation VuceticAdriana Presenter Germany Therapeutic OVERactivation of oncogenic signaling as a cancer treatment strategy dos Santos DiasMatheus Speaker The Netherlands Auditorium VIII

Time

Session

16:10

17:40

Cancer Researchers to watch - An early career showcase

(Separate pre-registration required)

JacquemetGuillaume Chair Finland

Reprogramming immunosuppressive tumor-associated macrophages potentiates standard-of-care therapy in melanoma

TichetMelanie Speaker Switzerland
Proffered Paper 3: SoxC transcription factors are oncoembryonic regulators of colon development and cancer

DalessiTosca Presenter Switzerland
Proffered Paper 4: Erythrocyte-derived sphingosine-1-phosphate promotes tumor cell survival in the circulation

VuceticAdriana Presenter Germany
Therapeutic OVERactivation of oncogenic signaling as a cancer treatment strategy

dos Santos DiasMatheus Speaker The Netherlands

Auditorium VIII

Monday, 16 June 2025

Time	Session

10:30 12:00	Cancer Researchers to watch - An early career showcase (Separate pre-registration required) dos Santos DiasMatheus Chair The Netherlands Attaching to and Crossing Endothelial Barriers JacquemetGuillaume Speaker Finland Proffered Paper 7: CD24-mediated differential platelets-tumor cells binding tunes metastatic progression LiboniCristina Presenter France Proffered Paper 8: Microfluidic Single-Cell Profiling in Prostate Cancer Bone Metastasis Reveals Ultra-Migratory Subpopulations, Tumour-Bone Crosstalk and CTC Heterogeneity. CottonThomasDaniele Presenter United Kingdom Omomyc is a promising anti-MYC therapy for pediatric medulloblastoma EscuderoLaura Speaker Canada Auditorium VIII

Time

Session

10:30

12:00

Cancer Researchers to watch - An early career showcase

(Separate pre-registration required)

dos Santos DiasMatheus Chair The Netherlands

Attaching to and Crossing Endothelial Barriers

JacquemetGuillaume Speaker Finland
Proffered Paper 7: CD24-mediated differential platelets-tumor cells binding tunes metastatic progression

LiboniCristina Presenter France
Proffered Paper 8: Microfluidic Single-Cell Profiling in Prostate Cancer Bone Metastasis Reveals Ultra-Migratory Subpopulations, Tumour-Bone Crosstalk and CTC Heterogeneity.

CottonThomasDaniele Presenter United Kingdom
Omomyc is a promising anti-MYC therapy for pediatric medulloblastoma

EscuderoLaura Speaker Canada

Auditorium VIII

Tuesday, 17 June 2025

Time	Session

09:20 10:55	Symposium: Early Onset Cancers EngCathy Co-Chair United States dos Santos DiasMatheus Co-Chair The Netherlands Genomic epidemiology approaches to elucidate the causes of Early onset colorectal cancer globally Perdomo VelasquezSandra Speaker France Proffered Paper: Geographic and age-related variations in mutational processes in colorectal cancer EACR25-1102 EACR25-1102 Díaz-GayMarcos Presenter Spain More Than Mutations: A Survival Guide for Nascent Tumours AlcoleaMaria Pilar Speaker United Kingdom Proffered Paper: Fibroblast specific endoglin deletion increases colorectal cancer tumorigenesis in a subset-specific manner EACR25-1472 EACR25-1472 AbudukelimuSubinuer Presenter Netherlands The burgeoning horizon of early-onset GI cancers EngCathy Speaker United States Auditorium VI+VII
11:35 13:10	Symposium: Clonal Hematopoiesis TrumppAndreas Co-Chair Germany dos Santos DiasMatheus Co-Chair The Netherlands Quantitative insights into somatic evolutionary dynamics in healthy and pre-malignant blood BlundellJamie Speaker United Kingdom Proffered Paper: Unveiling the role of migratory dendritic cells in liver cancer EACR25-0607 EACR25-0607 VolponiCamilla Presenter Italy Clonal Hematopoiesis and Cancer BernardElsa Speaker France Proffered Paper: Bulk and spatial B cell receptor repertoire analysis to characterize antibody maturation in relation to tertiary lymphoid structures and response to immunotherapy EACR25-2072 EACR25-2072 PupierGuilhem Presenter France Panel Discussion Auditorium II
15:20 16:55	Symposium: Senescence in Therapy Response TrumppAndreas Co-Chair Germany dos Santos DiasMatheus Co-Chair The Netherlands Harnessing senescence biology for immune oncology (REMOTE Presentation) LoweScott Speaker United States Proffered Paper: Targeting senescent macrophages inhibits metastatic dissemination in adrenocortical cancer EACR25-0260 EACR25-0260 ValPierre Presenter France Controlling therapy-induced senescence: novel approaches to senolysis KovatchevaMarta Speaker Italy Proffered Paper: Therapy-Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukemia Blasts through loss of PRC2-Mediated Regulation EACR25-0844 EACR25-0844 FuscoSimona Presenter Italy Plasticity of Leukemic Stem Cells TrumppAndreas Speaker Germany Auditorium II

Wednesday, 18 June 2025

Time	Session

15:20 16:55	Symposium: EC DNA DiveCaroline Co-Chair United Kingdom dos Santos DiasMatheus Co-Chair The Netherlands Extrachromosomal DNA (ecDNA): Cancer’s Dynamic Circular Genome MischelPaul Salomon Speaker United States Proffered Paper: Heterogeneous oncogene dosage driven by extrachromosomal DNA determines neuroblastoma response to therapy EACR25-0364 EACR25-0364 MontuoriGiulia Presenter Germany Functional Role of Extrachromosomal Circular DNA in Colorectal, Renal and Bladder Cancers RegenbergBirgitte Speaker Denmark Proffered Paper: Investigating the impact of extrachromosomal DNA amplification on cell fate decisions and therapy resistance EACR25-2262 EACR25-2262 SchmargonRachel Presenter Germany A general strategy to model ecDNA-mediated focal amplifications in cells and in mice VenturaAndrea Speaker Auditorium VIII
18:15 18:40	Posters in the Spotlight - Wednesday dos Santos DiasMatheus Moderator The Netherlands Dissecting ovarian cancer cellular responses to radioimmunotherapy with β- particle and ultra-short range conversion and Auger electron-emitting radionuclides. (EACR25-0133) P-552 EACR25-0133 GrzmilMichal Presenter Switzerland Pan-cancer analysis of successive whole genome duplication in the 100,000 Genomes Project (EACR25-0555) P-746 EACR25-0555 SmythEvie Presenter Ireland COX-2/PGE2 Activity in Cancer Cells: A Key Driver of Metastasis via Immune Escape (EACR25-0743) P-773 EACR25-0743 RussoMassimo Presenter United Kingdom Depleting tumour-infiltrating Tregs to enhance the efficacy of KRAS-mutant targeted therapies in lung cancer (EACR25-1513) P-790 EACR25-1513 de CastroAndrea Presenter United Kingdom Cytotoxic ILC-1 cells determine outcome of PD-(L)1 blockade in microsatellite instable cancers (EACR25-2039) P-522 EACR25-2039 Van RoyenPaula Presenter Netherlands Spotlight Theatre