SmythEvie Trinity College DublinIreland

I am a PhD student at Trinity College Dublin, specialising in computational oncology. My research focuses on understanding the consequences and drivers of extreme ploidy events in cancer evolution. I investigate the mechanisms underpinning whole genome duplication (WGD), excessive WGD events, and extreme chromosomal loss across diverse tumor types using pan-cancer datasets. By exploring these large-scale genomic alterations, my work aims to elucidate the evolutionary landscape of tumors and provide deeper insights into how ploidy changes shape cancer progression.