BaggioliniArianna Institute of Oncology ResearchSwitzerland

Time	Session

14:00 15:40	Cancer Researchers to watch - An early career showcase (Separate pre-registration required) BaggioliniArianna Chair Switzerland Welcome Message CaffarelMaria M. Chair Spain FAK Inhibition Promotes Critical Cytotoxic Interactions Between CD8 T Cells and Cancer Cells in Metastatic Breast Cancer BarthNicole Speaker United Kingdom Proffered Paper 1: Inhibition of Furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities ZIANE CHAOUCHE Lydia Presenter France Proffered Paper 2: Multimodal analysis of spatial transcriptomics data uncovers novel invasive lobular carcinoma subtypes SerraMatteo Presenter Belgium Targeting cytokine signalling to block cancer-promoting inflammation and tumour progression CaffarelMaria M. Speaker Spain Auditorium VIII

Time

Session

14:00

15:40

Cancer Researchers to watch - An early career showcase

(Separate pre-registration required)

BaggioliniArianna Chair Switzerland

Auditorium VIII

Time	Session

08:30 10:00	Cancer Researchers to watch - An early career showcase (Separate pre-registration required) CaffarelMaria M. Chair Spain Exploiting metabolic vulnerabilities to improve breast cancer therapy MorandiAndrea Speaker Italy Proffered Paper 5: Melting the Iceberg: Nanomedicines Overcoming Stromal Barriers and Recruiting Effector T Cells in Pancreatic Cancer AcúrcioCRita Presenter Portugal Proffered Paper 6: ENO3PEP vaccine enhances chemotherapy efficacy in pancreatic cancer by boosting anti-tumor immunity BrugiapagliaSilvia Presenter Italy Stem cells-based models of tumor initiation and metastasis BaggioliniArianna Speaker Switzerland Refreshment Break Auditorium VIII

Time

Session

08:30

10:00

Cancer Researchers to watch - An early career showcase

(Separate pre-registration required)

CaffarelMaria M. Chair Spain

Auditorium VIII

Time	Session

09:20 10:55	Symposium: Brain Metastasis BaggioliniArianna Co-Chair Switzerland JoyceJohanna A Co-Chair Switzerland Identifying and targeting metabolic vulnerabilities in leptomeningeal metastasis BoireAdrienne Speaker United States Proffered Paper: Reshaping Tumor-Vascular-Immune Crosstalk by VEGFR-3 Modulation in Breast Cancer Brain Metastases EACR25-1283 EACR25-1283 MacelaCarolina Presenter Portugal Strategies to challenge brain metastases in mice and human ValienteManuel Speaker Spain Proffered Paper: Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 EACR25-1678 EACR25-1678 SeehawerMarco Presenter United States Unraveling the Complexity of Cancer Ecosystems JoyceJohanna A Speaker Switzerland Auditorium II

Time

Session

09:20

10:55

Symposium: Brain Metastasis

BaggioliniArianna Co-Chair Switzerland

JoyceJohanna A Co-Chair Switzerland

Auditorium II

Time	Session

09:20 10:55	Symposium: Tumour Innervation BaggioliniArianna Co-Chair Switzerland WinklerFrank Co-Chair Germany The neural regulation of small cell lung cancer progression VenkateshHumsa Speaker United States Proffered Paper: Medullary sinus macrophages limit cancer therapy efficacy by an efferocytosis-induced IL-33/ST2 axis in the tumor-draining lymph node. EACR25-1319 EACR25-1319 LamorteSara Presenter Canada Neural mechanisms of brain tumor growth and resistance WinklerFrank Speaker Germany Proffered Paper: Spatially Resolved Analysis of Cancer-Infiltrated Nerves Identifies DRAXIN as a Marker of Injury Response with Tumor-Suppressive Potential EACR25-1355 EACR25-1355 OzgaJoannaAleksandra Presenter Switzerland Neural-tumour communication accelerates cancer progression and impairs treatment response SloanErica Speaker Australia Auditorium II

Time

Session

09:20

10:55

Symposium: Tumour Innervation

BaggioliniArianna Co-Chair Switzerland

WinklerFrank Co-Chair Germany

Auditorium II