POSTER SESSION - Tuesday

Poster Session Tuesday

Time	Session

10:45 20:00	BIOINFORMATICS AND COMPUTATIONAL BIOLOGY HALO Breast IHC AI: Demonstration of its Application as a Training Tool for Students P-001 EACR25-0176 Wiebke Solass Poster Presenter Switzerland From Transcriptomic Data to Therapeutic Potential: Drug Repositioning for Papillary Thyroid Carcinoma P-002 EACR25-0192 OZGE KARABIYIK ACAR Poster Presenter Turkey MetaboDynamics: a Bioconductor package for the probabilistic analysis of longitudinal metabolomics data P-003 EACR25-0282 Katja Danielzik Poster Presenter Germany Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy P-004 EACR25-0320 Simon Syga Poster Presenter Germany Deep Learning-Based PET Synthesis from CT Scans: Advancing Abdominal Lymph Node Metastasis Assessment P-005 EACR25-0400 Gong Wenjing Poster Presenter China Weave: a software package for integrated spatial multi-omics visualization and data analysis P-006 EACR25-0476 Alice Ly Poster Presenter Belgium Optimizing Chemoradiotherapy for Malignant Gliomas Using a Validated Mathematical Model and In Silico Trials P-007 EACR25-0534 Italia Matteo Poster Presenter Spain Multi-Cancer Early Detection and Tumor localization in Women Using Metabolomics-Based Machine Learning Models P-008 EACR25-0572 Yan Li Poster Presenter China Computational identification of pan-cancer multi-omic metabolic signatures as prognostic biomarkers and therapeutic targets P-009 EACR25-0678 Higor Almeida Cordeiro Nogueira Poster Presenter Brazil Using the CancerHubs approach and web application to define novel cancer-related protein interaction hubs P-010 EACR25-0724 Nicola Manfrini Poster Presenter Italy A Smart Platform for Cancer Research: Integrating Consensus Meta-Analysis of Omics Data with Ontology-Based Network Analysis P-011 EACR25-0756 Sukjoon Yoon Poster Presenter Korea (Republic of) Panoptic Segmentation and Spatial Analysis of Whole Slide Images: A Unified Open-Source Framework P-012 EACR25-0770 Jaakko Oskari Lehtonen Poster Presenter Finland Developing an artificial intelligence model for clinical benefit prediction in breast cancer P-013 EACR25-0836 Ankita Murmu Poster Presenter Hungary Co-dysregulation of Redox and Ca²⁺ homeostasis-associated genes and its prognostic significance in Breast Cancer P-902 EACR25-0886 Ana Sofia Fonseca Ramos Poster Presenter Portugal Artificial intelligence-based pathological analysis for Gleason grade and tumor quantification in prostate cancers P-014 EACR25-0970 KyungHwan Kim Poster Presenter Korea (Republic of) Predicting drug response from omics data using MultiOmic2Drug P-015 EACR25-1184 Frederic Saab Poster Presenter Germany Novel clustering of glioblastoma patients with EGFR mutation by unsupervised machine learning P-016 EACR25-1234 Clara Gavira-O'Neill Poster Presenter Spain MetaAnalysisOnline’s Network Tool: Simplifying Network Meta-Analysis for All Researchers P-017 EACR25-1252 Ot Poster Presenter Hungary Enhancing Mutational Signature Detection in Whole Exome Sequencing: Insights from Esophageal Squamous-Cell Carcinoma P-018 EACR25-1306 Kubra Yilmaz Poster Presenter Turkey Single Cell Transcriptomics Reveals Hallmark Enrichment in Luminal A and Triple Negative Breast Cancers P-019 EACR25-1406 Ot Poster Presenter Hungary Linking in situ phenotyping of intestinal stem cells to functional analyses of patient-derived organoids as a risk stratification strategy during follow-up monitoring of CRC patients P-020 EACR25-1476 Annika Raschdorf Poster Presenter Germany Good Models or Good Riddance: A Guide for Researchers on Choosing Optimal Cell Lines for Translational Ovarian Cancer Research P-021 EACR25-1478 Aideen McCabe Poster Presenter Ireland Prediction of Rectal Cancer Complete Response to Chemoradiotherapy by Multiscale Imaging and Deep Learning Analyses (PRECORMIDEL) P-022 EACR25-1570 Camila Sarmiento Poster Presenter Portugal Development of a mathematical model for early prediction of relapses in colorectal cancer P-023 EACR25-1610 Marta S Poster Presenter Spain Deciphering the Role of Stress Granules: Dampening Inflammation in Cancer through Mitochondrial RNA Sequestration P-024 EACR25-1680 Alexandre Miguel Kaizeler Guedes da Silva Kaizeler Poster Presenter Portugal A semi-automated approach for detecting minimal residual disease with single-tube by flow cytometry in pediatric acute myeloid leukemia P-025 EACR25-1696 Talita Fernandes Nunes Poster Presenter Brazil Monte Carlo Simulation of Gold Nanoparticles in Glioblastoma Radiotherapy: Impact on Survival and DNA damage under Co-60 γ-radiation and 160 kVp X-rays P-026 EACR25-1880 Joana Antunes Poster Presenter Portugal Deep learning in digital histopathology for clinically applicable biomarker discovery in prostate cancer P-027 EACR25-1936 Niamh Murphy Poster Presenter United Kingdom Unravelling HR-positive, HER2-negative Breast Cancer and its Tumor Microenvironment Heterogeneity Using Spatial Transcriptomics P-028 EACR25-1940 Bengisu Karak Poster Presenter Belgium Multiomic network-based modelling in Polish High-Grade Serous Ovarian Cancer (HGSOC) patients reveals prognostic importance of RAD21 and miR-4516 P-029 EACR25-1986 Karolina Chwialkowska Poster Presenter Poland In-silico Approach to Uncover Biomarkers and Therapeutic Targets in Metastatic Oral Squamous Cell Carcinoma P-030 EACR25-2050 Clarissa Gurgel Poster Presenter Brazil Unveiling the spatial regulation of chemoresistance in ovarian cancer P-031 EACR25-2052 Sara Palomino Echeverria Poster Presenter Finland Machine Learning-Driven Drug Repositioning for Oral Squamous Cell Carcinoma: A Predictive Approach Using Affinity2Vec P-032 EACR25-2056 Gisele Vieira Rocha Poster Presenter Brazil Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment P-033 EACR25-2076 Priscila Galv Poster Presenter Brazil Spatially resolved OMICs defines specific immune-tumor niches in esophageal adenocarcinoma responders to neoadjuvant chemotherapy P-034 EACR25-2134 Giulia Lopatriello Poster Presenter Italy TNMv2: online tool to perfrom stage specific gene expression analysis P-035 EACR25-2256 Dalma M Poster Presenter Hungary Assessing the maturation stages of PMN-MDSC to dissect the immunosuppressive mechanisms within TME P-036 EACR25-2278 Sergio Forcelloni Poster Presenter Italy Modelling Somatic Alterations with Protein Language Models P-037 EACR25-2312 Luis Fernando Iglesias-Martinez Poster Presenter Ireland Development of a liquid biopsy test for Ovarian Cancer using Fragmentomic Characterization of blood samples. P-038 EACR25-2334 Pilib Poster Presenter Ireland YOLO-based approach for breast cancer tumour detection and segmentation in MRI scans P-039 EACR25-2412 Alicja Aleksandra Staśczak Poster Presenter Poland Characterizing Aggressiveness of Prostate Cancer with Large-scale DNA Organization Image Analysis P-040 EACR25-2422 martial guillaud Poster Presenter Canada RabAnalyser: a computational framework to measure the cell-to-cell variability of Rab GTPases organization P-041 EACR25-2486 Simone Tealdi Poster Presenter Italy Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics P-041A EACR25-03670 Javier Batista Perez Poster Presenter Poster and Exhibition Hall
10:45 20:00	BIOMARKERS IN TISSUE AND BLOOD Detection of Circulating Tumour DNA (ctDNA) with ddPCR and NGS in Liposarcoma P-042 EACR25-0048 Michael Wong Poster Presenter United Kingdom The systemic inflammation response index (SIRI) may identify less toxic treatments for specific advanced pancreatic adenocarcinoma patients P-043 EACR25-0110 Roc Poster Presenter Spain miR-7974: A predictor of poor prognosis and link to autophagy in ER+ breast cancer P-044 EACR25-0160 Stralina Eneh Poster Presenter Finland Unravelling predictors of response to dual HER2 blockade in HER2+ metastatic breast cancer using single-cell peripheral immune profiling P-045 EACR25-0258 Sofia Batalha Poster Presenter Portugal Czech Metastatic Colorectal Cancer Patients: their Copy Number Variation and Clinical Response to Chemotherapy and Bevacizumab P-046 EACR25-0322 Jana Stranska Poster Presenter Czech Republic Colorectal cancer patients comprehensive genomic profiling using TruSight Oncology 500 P-047 EACR25-0354 Zuzana Rozankova Poster Presenter Czech Republic AREG or EREG Overexpression Identifies a Subset of Gastro-Esophageal Adenocarcinoma Patients Responsive to EGFR Targeting P-048 EACR25-0360 Daniela Conticelli Poster Presenter Italy LGALS3BP’s role in bladder cancer: a potential urinary biomarker and therapeutic target P-049 EACR25-0386 Gianluca sala Poster Presenter Italy Detection of high molecular weight DNA contaminations in cell-free DNA samples P-050 EACR25-0394 Annika Dorn Poster Presenter Germany Liquid Biopsy-Based Biomarkers for Predicting Radiotherapy Response in Locally Advanced Head and Neck Squamous Cell Carcinoma P-051 EACR25-0474 Ariwan Othman Saeed Poster Presenter Iraq Serum metabolomic profiling unveils a metabolite marker panel for early detection of colorectal cancer P-052 EACR25-0520 Yanqun Liu Poster Presenter Singapore Detection rate for ESR1 mutations is higher in circulating-tumor-cell-derived genomic DNA than in paired plasma cell-free DNA samples as revealed by ddPCR P-053 EACR25-0528 Aliki Ntzifa Poster Presenter Greece THOR Methylation signatures in liquid biopsies for early breast cancer detection P-054 EACR25-0530 C Poster Presenter Portugal Integrating tumor fraction, next generation sequencing and qPCR analysis in liquid biopsy of EGFR-mutated non-small cell lung cancer patients P-055 EACR25-0608 Elisabetta Lazzarini Poster Presenter Italy Evaluation of a novel protein-based assay for multi-cancer early detection P-056 EACR25-0664 Nike Walter Poster Presenter Germany A novel therapeutic approach for metastatic medulloblastoma P-057 EACR25-0804 Carlos Cust Poster Presenter Portugal Changing the paradigm of liquid biopsy storage without cold chain. In-vitro validation of a preservative medium for circulating tumor HPV-DNA stabilization. P-058 EACR25-0808 Chiara Senti Poster Presenter Italy Non-Invasive Detection of Circulating mRNA Markers in Colorectal Diseases P-059 EACR25-0850 Veronika Vymetalkova Poster Presenter Czech Republic The expression of the tight junctional protein complex Occludin (OCLN) and Zonula Occludens 1 (ZO-1) in human colon cancer and assessment of disease progression and therapeutic responses P-060 EACR25-0868 Qirui Tian Poster Presenter United Kingdom Predicting Second-Line Chemotherapy Outcome in Advanced Pancreatic Cancer: A Machine Learning Approach Using PBMC-Based Biomarkers - Translational Findings from the PREDICT Trial P-062 EACR25-1212 Anton Lahusen Poster Presenter Germany Elevated monocyte-lymphocyte ratio as a prognostic and predictive biomarker of poor response to radio-immunotherapy in advanced cancer: correlation with immune and metabolic dysregulation P-063 EACR25-1236 Daphne Morel Poster Presenter France Characterization of miRNA profiles in different subtypes of colorectal adenomas in tissue and fecal samples P-064 EACR25-1274 Amedeo Gagliardi Poster Presenter Italy Differential protein expression in platelets collected from glioma patients and healthy controls: A Comparative Study P-065 EACR25-1284 Vibecke H Poster Presenter Norway Unraveling Tumor Genetics: The Role of cfDNA Whole-Exome Sequencing for Tracking Tumor Evolution and Treatment Response P-066 EACR25-1380 Viola Bianca Serio Poster Presenter Italy Establishing a plasma protein signature for clear cell renal cell carcinoma P-067 EACR25-1390 Harini Lakshminarayanan Poster Presenter Switzerland Aberrant miRNA expression in papillary thyroid carcinoma– clinical applications P-068 EACR25-1404 Nikolay Hristov Mehterov Poster Presenter Bulgaria Patient-specific cell-free RNA alterations enable cancer classification P-069 EACR25-1532 Annelien Morlion Poster Presenter Belgium ddPCR as molecular approach to assess MSI-H status in PDAC EUS-FNB samples P-070 EACR25-1548 Elisa Boldrin Poster Presenter Italy microRNA profile associated with the aggressive potential of salivary gland mucoepidermoid carcinoma P-070A EACR25-1642 Claudia Malheiros Coutinho-Camillo Poster Presenter Brazil Immune-Related Gene Signature in Melanoma Lymph Node Metastasis: A 6-Gene Predictive Model P-071 EACR25-1654 Vin Poster Presenter Brazil Improving Cancer Screening and Monitoring: The Potential of Oncofetal Chondroitin Sulfate Proteoglycans in Liquid Biopsies P-072 EACR25-1720 Maj Sofie Poster Presenter Denmark Profiling immunological signatures in the peripheral blood of patients with stage III non-small cell lung cancer treated with chemoradiation and adjuvant durvalumab P-073 EACR25-1736 Natasa Pavlovic Poster Presenter Sweden Fecal miRNA profiles and gut metagenome composition in Lynch syndrome: results from a study on human subjects and a mouse model P-074 EACR25-1802 Giulia Francescato Poster Presenter Italy Monitoring Cystatin F Dynamics in Melanoma Patients Undergoing Checkpoint Inhibitor Therapy P-075 EACR25-1828 Milica Perisic Nanut Poster Presenter Slovenia Defining blood-based immune biomarkers to improve early lung cancer detection during community lung health checks P-076 EACR25-1834 Ryan James Hodgetts Poster Presenter United Kingdom Extracellular Vesicle-Associated miRNA downregulation dynamics during acquisition of enzalutamide resistance: implications for early detection and RNA-based therapeutic opportunities P-908 EACR25-1882 Mariana Filipa Couto Ferreira Poster Presenter Portugal Inertial Microfluidics for Circulating Tumor Cell (CTC) Separation with Serpentine Channels: A Numerical and Experimental Study P-077 EACR25-1958 Ramazan Ceylan Poster Presenter Turkey Capturing the Full Spectrum: High Dynamic Range Biomarker Detection with Photon Upconverting Nanoparticles P-078 EACR25-1978 sanna karin wallenborg Poster Presenter Sweden Optical Genome Mapping for detecting Homologous Recombination Deficiency in breast and ovarian cancers P-079 EACR25-2032 Sandra Vanhuele Poster Presenter France Combined microfluidic isolation and immunofluorescence staining of circulating tumour cells for the assessment of Androgen Receptor expression in metastatic Prostate cancer blood samples. P-080 EACR25-2044 David Allan John Greaves Poster Presenter United Kingdom Unveiling the Role of Extracellular Vesicle miRNAs in HCC Pathogenesis and Therapy P-081 EACR25-2168 Virginia Manuti Poster Presenter Italy Comparative molecular analysis of CTCs and cfDNA Detection using Parsortix® System P-082 EACR25-2198 Megan Abigail Coates Poster Presenter United Kingdom Machine Learning Analysis of cfDNA Fragment Patterns from Minimal Coverage Whole Genome Sequencing Data for Cancer Detection P-083 EACR25-2206 Zuzana Hanzl Poster Presenter Slovakia MicroRNAs for the Detection of Basal Breast Tumor Subtype. P-084 EACR25-2216 Kelsey Bruce Poster Presenter Ireland Systemic dissemination in glioblastoma multiforme patients P-085 EACR25-2234 Pavel Stejskal Poster Presenter Czech Republic Circulating miRNAs prognostic signature in bladder cancer: integrative analysis in patient-derived xenografts (PDXs) and cancer patients P-091A EACR25-2242 Margaritis Avgeris Poster Presenter Greece Elevated miR-21-5p Expression as a Prognostic Biomarker in Cervical Cancer: Insights from the Indian Patient Cohort P-086 EACR25-2266 Kiran Siwach Poster Presenter India miRNA profiling in bile extracellular vesicles from cholangiocarcinoma patients P-087 EACR25-2308 Margalida Torrens-Mas Poster Presenter Spain Detection of circulating metastasis-initiating cells predicts therapy efficacy and prognosis in lung cancer patients treated with neoadjuvant chemotherapy. P-088 EACR25-2368 Giulia Bertolini Poster Presenter Italy Leveraging MicroRNA Biomarkers to Dissect PD-L1 Regulation and Improve Immunotherapy Response in Lung Cancer P-089 EACR25-2392 Miriam Kuku Afanga Poster Presenter Italy Novel blood-based protein biomarker signature for early detection of colorectal cancer and advanced adenomas P-090 EACR25-2478 Christos F Fotis Poster Presenter Greece Extracellular Vesicles in Stool: Unlocking New Protein Biomarkers for Colorectal Cancer and Premalignant Lesions P-091 EACR25-2504 Daniel Gabriel Pons Poster Presenter Spain Poster and Exhibition Hall
10:45 20:00	CANCER CELL BIOLOGY Downregulation of MicroRNA-497-5p Promotes Tumor Cell Malignancy and Contributes to Hepatitis B Virus-Related Hepatocellular Carcinoma Recurrence P-092 EACR25-0056 Chiao-Fang Teng Poster Presenter Taiwan The integrated stress response drives MET oncogene overexpression in cancers P-093 EACR25-0112 Dogus Murat Altintas Poster Presenter Italy Effects of the anti-diabetic dipeptidyl-peptidase 4 inhibitor on radiation response in breast carcinoma cells with different metastatic potential P-094 EACR25-0122 Marie Theres Eling Poster Presenter Austria Unique lipidomic signature in colorectal adenocarcinoma P-095 EACR25-0124 Yuki Agarwala Poster Presenter United Kingdom Characterizing Bladder Cancer Cells: Morphological and Biophysical Signatures for Advanced Label-Free Detection P-096 EACR25-0136 Rapha Poster Presenter Portugal Studying Stem Cell Fate & Plasticity in Pre-cancerous Gastric Organoids P-097 EACR25-0138 Callum Patrick Alun Oddy Poster Presenter United Kingdom Increasing autophagy activity suppresses Helicobacter pylori related gastric cancer tumorigenesis P-098 EACR25-0150 Hsiao-Sheng Liu Poster Presenter Taiwan Intracellular Ca2+ depletion induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane resulting in accelerated G2/M cell cycle transition P-099 EACR25-0172 Wen-Tai Chiu Poster Presenter Taiwan Using organoids and Drosophila to explore the role of protein kinase N as an intestinal tumour suppressor P-100 EACR25-0200 Ashley Campbell Poster Presenter United Kingdom Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using two-dimensional and three-dimensional in vitro culture models P-101 EACR25-0242 Wassim Abou-Kheir Poster Presenter Lebanon ADAR2-dependent editing activity induces the differentiation of osteosarcoma cells by targeting IGFBP7 P-102 EACR25-0248 Michela Rossi Poster Presenter Italy Constituent compounds from Bazi Bushen regulate autophagy and improve the senescence feature of vascular endothelial cells P-104 EACR25-0318 Amber Li Poster Presenter United Kingdom Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C. P-105 EACR25-0330 Kyah van Megesen Poster Presenter Netherlands Exploring the Tumor-Suppressive Role of MLN51 (Metastatic Lymph Node 51) in Lung Adenocarcinoma P-106 EACR25-0334 huijuan zhang Poster Presenter United Kingdom PFKFB4 mediates cell migration through regulating MX1 and MX2 expression in oral squamous cell carcinoma P-107 EACR25-0340 Chiao-Wen Lin Poster Presenter Taiwan Epigenetic regulation by histone modification in the epithelial-to-mesenchymal transition of lung cancer brain metastasis P-108 EACR25-0362 YOUNG ZOON KIM Poster Presenter Korea (Republic of) A multi-omics approach to dissect cell-intrinsic functions of IDO1 in ovarian cancer P-109 EACR25-0366 Teng Teng Xu Poster Presenter Germany Deciphering the Breast Cancer Metastasis Transcriptome: A Deep Dive into the Enigmatic Role of Circular RNAs. P-110 EACR25-0426 Adrian Szczepaniak Poster Presenter Poland Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma P-111 EACR25-0430 Ming-Hsien Chien Poster Presenter Taiwan Sesamin inhibits human colorectal cancer HCT-116 cell growth by inducing apoptosis P-112 EACR25-0432 Hsieh Shu-Ling Poster Presenter Taiwan KSRP-mediated Wnt/β-catenin activation promotes follicular thyroid cancer progression and stemness P-113 EACR25-0434 Kuo-Tai Hua Poster Presenter Taiwan The Effect of RG7388 and Etoposide Combination on Cell Death in a Neuroblastoma Cell Line P-114 EACR25-0436 Selda Kabadere Poster Presenter Turkey "FastM": a fasting-mimicking cell culture medium for refined cancer research P-115 EACR25-0442 Theresia Weiermair Poster Presenter Austria Investigating COPZ1 dependency in in vitro murine models of Thyroid Cancer P-116 EACR25-0510 Debora Vergaro Poster Presenter Italy Regulation of EMT by the U-BOX Domain of CHIP/STUB1 in Colon Cancer Cells P-117 EACR25-0512 JIYOUNG PARK Poster Presenter Korea (Republic of) Macroautophagy as a hallmark in colorectal cancer P-905 EACR25-0538 Tsvetomira Georgieva Ivanova Poster Presenter Bulgaria Novel 1-benzhydryl piperazine scaffold-based HDAC inhibitor b7 induces synergistic antiproliferative effect with vemurafenib in colorectal cancer cells harboring BRAF mutation P-118 EACR25-0554 Ana Vuleti_ Poster Presenter Serbia LOXL2 Inhibition: A New Strategy for Triple-Negative Breast Cancer P-119 EACR25-0556 Sandra Ferreira Poster Presenter Portugal Nutlin-3a Inhibits Lysosomal Fusion by Inducing SNARE Dysfunction in KRAS mutant/p53 Wild-Type Lung Cancer P-120 EACR25-0564 Soohyun Sim Poster Presenter Korea (Republic of) Heterogeneous and dynamic response of squamous esophageal cancer to CDK4/6 inhibition. P-121 EACR25-0584 Fabiana Moresi Poster Presenter Belgium TACSTD2 expression is a marker for the early formation of colon adenoma P-122 EACR25-0626 Kerstin Huebner Poster Presenter Germany Beta-catenin differential expression in salivary gland tumors from intercalated duct: an immunohistochemical and molecular study P-123 EACR25-0682 Carolinne Alves de Oliveira Poster Presenter Brazil Repurposing Antihistamines: Exploring Their Potential as N-WASP Inhibitors in Breast Cancer Metastasis P-124 EACR25-0684 Yannan Yu Poster Presenter United Kingdom Western diet-associated colonic insulin resistance boosts DNA error-prone quiescent stem cells and senescence of the homeostatic LGR5+ stem cells in the colon P-126 EACR25-0736 Lea Christiansen Poster Presenter Germany Low-density lipoprotein receptor-related protein 11 promotes lung adenocarcinoma proliferation by suppressing ubiquitin like modifier activating enzyme 7 P-127 EACR25-0760 Takumi Kiwaki Poster Presenter Japan Deciphering how the TRMP7 channel is involved in breast cancer modulation P-128 EACR25-0774 Marialaura Giannaccari Poster Presenter Italy Investigation of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene P-129 EACR25-0796 Pranoy Sahu Poster Presenter Italy Role of the antioxidant metabolism (AM) at various EMT/MET states of pancreatic ductal adenocarcinoma (PDAC) cells P-130 EACR25-0806 Dinara Baiskhanova Poster Presenter Germany Targeting KDM4-Driven Metabolic Reprogramming in Castration-Resistant Prostate Cancer P-131 EACR25-0810 Wen-Ching Wang Poster Presenter Taiwan Urea cycle upregulation is a metabolic adaptation driving liver-specific metastatic organotropism P-132 EACR25-0820 V Poster Presenter Spain Restoration of Drug Sensitivity and Apoptosis to Drug-Resistant Oesophageal Cancer Cells by USP18 Knockdown in the Presence of IFN-α or Poly (I:C) P-133 EACR25-0854 Maria Carey Poster Presenter Ireland Epithelial Protein Lost in Neoplasm (EPLIN) in Head and Neck Cancer: A Prospective Oncogenic Molecule Linked with Prognosis P-134 EACR25-0858 CAI WANG Poster Presenter United Kingdom Discovering Potential Anti-Oral Squamous Cell Carcinoma Mechanisms from Kochiae Fructus Using Network-Based Pharmacology Analysis and Experimental Validation P-135 EACR25-0864 Eui-Suk Sung Poster Presenter Korea (Republic of) Therapy-induced senescence of bone-marrow mesenchymal stem cells contribute to increased cell invasiveness, stemness, vascular mimicry and macrophages recrutiment in TNBC by inducing PD-L1 overexpression P-136 EACR25-0870 Angela Costagliola di Polidoro Poster Presenter Italy Aged-dependent metabolic reprogramming of microglia as a determinant factor in the development and progression of brain metastases P-137 EACR25-0874 Pablo Castillo Serrulla Poster Presenter Spain Molecular and Epigenetic Signatures of Senescence: Investigating Clonal Expansion and Chromatin Remodeling in HUVECs P-138 EACR25-0896 Cynthia Lau Poster Presenter United Kingdom Targeting CKAP2 to boost Chemotherapy Efficacy and alleviate immunosuppressive environment in non-small cell lung cancer P-139 EACR25-0936 Sai Fung Yeung Poster Presenter Regulation of Cancer Stemness by Hypoxia-Induced Metabolic Shifts and BNIP3-Driven Mitophagy in OECM-1 CSCs P-140 EACR25-0946 Chi Yuan Li Poster Presenter Taiwan Colon cancer cells metabolic plasticity: oxidative metabolism helps cancer cells to survive under glucose-deprivation P-141 EACR25-1006 Subha Ranjan Das Poster Presenter Israel OXPHOS targeting of MYCN-amplified neuroblastoma P-142 EACR25-1020 Soraya Epp Poster Presenter Ireland Targeting cell cycle vulnerabilities and signalling rewiring in p53 deficient cancers P-143 EACR25-1030 Irina Titkova Poster Presenter United Kingdom TARGETING FATTY ACID OXIDATION TO BOOST THE ANTITUMOR EFFECTS OF NUTRIENT STARVATION IN SOLID MALIGNANCIES P-144 EACR25-1048 Marzia Santamaria Poster Presenter Italy PSRC1 promotes oncogenic dedifferentiation in TP53-mutated hepatocellular carcinoma P-145 EACR25-1050 Jingyi Yuan Poster Presenter Hong Kong, China Activation of the p38/AP-1 Signaling Pathway by PFKFB4 Promotes ANXA2 Expression and Osteosarcoma Metastasis P-146 EACR25-1058 Jia-Sin Yang Poster Presenter Taiwan Interconnections among MET tyrosine kinase receptor, NMDAR, glutamine metabolism, and stress response in cancer progression P-147 EACR25-1082 Simona Gallo Poster Presenter Italy Plasticity of esophageal progenitors in fine-tuned by their microenvironment in vivo P-148 EACR25-1162 Louison Descampe Poster Presenter Belgium Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho P-149 EACR25-1168 Marana Abboud Poster Presenter Israel Pathophysiological Mechanisms of Pancreatic Islet Dysfunction in Pancreatic Ductal Adenocarcinoma P-150 EACR25-1174 Nieves Casillas-Ruiz Poster Presenter Spain Degradation of IDH1 via Chaperone-mediated autophagy inhibits cell cycle progression in glioblastoma P-151 EACR25-1210 Wanjun TANG Poster Presenter Hong Kong, China Increased OGT activity promotes nuclear localization of RNA polymerase II to support oncogenic transcription P-152 EACR25-1214 Satu Pallasaho Poster Presenter Finland AHSG exacerbates malignant progression in lung adenocarcinoma through ubiquitination mediated degradation of GSK3β P-153 EACR25-1248 Moyna Kalia Poster Presenter India The effect of Ibuprofen on autophagic gene expression in Hepatocellular Cancer P-154 EACR25-1268 Esra TOKAY Poster Presenter Turkey Mechanisms regulating the formation of colorectal cancer brain metastasis P-155 EACR25-1294 Khair-Dabbour Gazi Fayhaa Poster Presenter Israel Senescence Induction Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy P-156 EACR25-1308 Xuhui Ma Poster Presenter China Impact of 5-Ethynyl-2′-deoxyuridine (EdU) on Chaperone-Mediated Autophagy and Key Cellular Processes in U-87MG Glioma Cells P-125 EACR25-1316 Ceren Gencel Guler Poster Presenter United Kingdom Comparative analysis of regorafenib's effects in human and canine osteosarcoma cell lines: an interdisciplinary and translational perspective on bone tumor therapy P-157 EACR25-1320 Klaudia Marcinkowska Poster Presenter Poland Metastatic ovarian cancer drives fundamental tissue reprogramming in the human omentum P-158 EACR25-1324 Francis Jacob Poster Presenter Switzerland Mechanisms of AICAr-Induced Acute Myeloid Leukemia Differentiation: Role of Ribonucleotide Metabolism and Replication Stress P-159 EACR25-1352 Alojzija Brcic Poster Presenter Croatia CFTR modulator drugs can reduce the invasive properties of colorectal cancer cells P-160 EACR25-1356 V Poster Presenter Portugal TGF-β induced EMT may promote tolerance of mitotic errors and genomic instability through inhibition of p53/p21pathway. P-162 EACR25-1364 Livia del Rocio Lopez Noriega Poster Presenter Spain Investigating the effects of culture medium derived from HEK293 cells expressing DDB2^PCNA- protein on microenvironment. P-163 EACR25-1430 Priyam Ghosh Poster Presenter Italy The RHO exchange factor VAV3 shows unexpected tumor suppressor roles in non-small cell lung cancer P-164 EACR25-1494 Alejandra Leyton Pereira Poster Presenter Spain Identification of TGM2 as a Key Mediator of Autophagy-Driven Chemoresistance in p53-R282W expressing Cancer Cells P-165 EACR25-1500 Sourav Chakraborty Poster Presenter India FGF/FGFR System in Medulloblastoma: New Approaches for Tumor Treatment. P-166 EACR25-1502 Nicolas Tassone Poster Presenter Italy Modulation of CITED2 Expression Unveils Different Biological Functions in Glioblastoma P-913 EACR25-1506 C Poster Presenter Portugal Elucidating how nutrient dynamics in the tumor microenvironment modulates cancer metastasis P-168 EACR25-1512 Sara Laine Poster Presenter Spain Crosstalk between autophagy and apoptosis induced by unsymmetrical bisacridines in pancreatic cancer cells P-169 EACR25-1530 Agnieszka Kurdyn Poster Presenter Poland Trigger ferroptosis in breast cancer cells (BC) by targeting xCT and FATP1 P-170 EACR25-1564 Bruna Abreu Poster Presenter Portugal Cell-cell adhesion disruption promotes stress granules formation: A survival strategy in Inflammatory Breast Cancer P-171 EACR25-1586 Maria Miguel Castro Poster Presenter Portugal Dual Cyclin-CDK Inhibition by Plant-Derived Hexadecanoic Acid Triggers G1/S Arrest P-172 EACR25-1588 Sasha Alecia Wright Poster Presenter Jamaica The impact of the microsporidia Encephalitozoon intestinalis on colorectal carcinogenesis P-173 EACR25-1590 Leslie Vercruysse Poster Presenter France Therapeutic approaches to primary NRAS-driven leptomeningeal melanoma P-174 EACR25-1596 Mohammad Rabii Poster Presenter United Kingdom Investigating the Therapeutic Potential of Antidiabetic Drugs, Metformin and Canagliflozin, in Papillary Thyroid Carcinoma P-175 EACR25-1598 Mariana Barreto Gon Poster Presenter Portugal Deciphering the Role of Gasdermin B and D in Endometrial Cancer: A Multidisciplinary Approach P-176 EACR25-1608 Ignacio Marina Bueno Poster Presenter Spain Characterization of Patient-derived xenograft (PDX) - derived organoids (PDXOs) to Find New Treatment Strategies for LKB1-Mutated NSCLC P-177 EACR25-1640 Aurora Paffetti Poster Presenter Italy Ferredoxin 2 is critical for tumor suppression and lipid homeostasis but dispensable for embryonic development P-178 EACR25-1662 Jin Zhang Poster Presenter United States Modeling gastric intestinal metaplasia in organoids: role of TP53 loss-of-function P-179 EACR25-1668 Mar Reines Poster Presenter Germany Epigallocatechin gallate (EGCG) augments the anti-leukaemic effect of L-asparaginase in childhood B-cell acute lymphoblastic leukaemia cells P-180 EACR25-1712 Yana Feodorova Poster Presenter Bulgaria Age-related effects in cancer therapy are driven by local and systemic changes in immune response P-181 EACR25-1722 Ana Vitlic Poster Presenter United Kingdom Functional Characterization of UBX Domain Protein 7 (UBXN7) in Glioblastoma: Implications for Tumor Progression P-182 EACR25-1724 Marta Domenech Poster Presenter Spain NRF2 activation by myeloid cell-derived oxidative stress induces SNAI-driven EMT and metastasis in breast cancer P-183 EACR25-1730 Olivia Naemi Elisabeth Johnsson Poster Presenter Sweden Serum-related Metabolic stress and Breast Cancer: Differential Responses in Metastatic versus Non-Metastatic Cells P-184 EACR25-1748 Gunel Mukhtarova Poster Presenter Turkey Cytokine and chemokine screening reveals altered NK-DC-T cell crosstalk in the aged tumor microenvironment P-184 EACR25-17890 Natasa Pavlovic Poster Presenter Sweden Loss of LKB1 in non-small cell lung carcinoma favours EMT-independent metastasis P-185 EACR25-1804 Adriana Martinez Turtos Poster Presenter Denmark Kv1.3 potassium channel-linked signaling networks based on STAT3 function are crucial for melanoma tumorigenesis P-186 EACR25-1818 Luca Matteo Todesca Poster Presenter Italy Investigation of novel heterocyclic fused naphthalimides as DNA-intercalating agents with antitumor potential P-187 EACR25-1846 Zlatina Vlahova Poster Presenter Bulgaria Structural Regulation of Gasdermin B Cytotoxic Activity: Insights into its Potential as a Therapeutic Target in Cancer P-188 EACR25-1848 Sara Colomo del Pino Poster Presenter Spain Genetic ablation of NOX2 boosts anti-tumor immunity yet accelerates metastasis in the PyMT-MMTV breast cancer model P-189 EACR25-1866 Mustafa Kaya Poster Presenter Sweden Targeting glycation stress in chemoresistant colon cancer: Effects on cancer stem cells P-190 EACR25-1878 Akeila BELLAHCENE Poster Presenter Belgium Identifying novel regulators of the BH3-only protein PUMA using whole genome CRISPR/Cas9 KO screens to enhance the efficacy of cancer treatment P-191 EACR25-1902 Deeksha Kaloni Poster Presenter Australia Peroxidasin promotes epithelial-mesenchymal transition and invasion in metastatic melanoma P-192 EACR25-1938 Martina Paumann-Page Poster Presenter New Zealand mTORC2 but not mTORC1 governs cellular metabolic landscape in Calreticulin (CALR) mutated myeloproliferative neoplasm (MPN) P-193 EACR25-1948 Saadia Naseer Poster Presenter India Modification of β-Catenin by MCPIP1 endonuclease Activity regulates the metastatic potential of ccRCC P-194 EACR25-1950 Judyta G Poster Presenter Poland The pro-invasive MAP4 kinases promote tissue invasion and selectively modulate interactions with the neural TME in medulloblastoma. P-195 EACR25-1962 Martin Baumgartner Poster Presenter Switzerland Novel liposomal nanoformulations containing cannabidiol, celecoxib and 2,5-dimethylcelecoxib induce cell cycle arrest and apoptosis in glioblastoma cells P-196 EACR25-1982 Aleksandra Majchrzak-Celi_ska Poster Presenter Poland Understanding the role of desmoglein 2 in preserving the epithelial phenotype of breast cancer cells P-197 EACR25-1990 Karel Sou_ek Poster Presenter Czech Republic Impact of androgen receptor expression on the efficacy of anti-androgen therapies in triple negative breast cancer P-198 EACR25-1996 Bel Poster Presenter Spain Exploring the oncogenic role of the deubiquitinase USP7 in pancreatic cancer using PROTAC technology P-199 EACR25-2006 Sebastian Urban Poster Presenter Germany SUMOylation of S6K2 May Confer Its Stabilization Contributing To The Survival of Breast Cancer Cells P-200 EACR25-2018 Nurettin Ilter Sever Poster Presenter Turkey Identification of a novel gene-signature driver of cancer malignancy P-903 EACR25-2086 Maddalen Otaegi Poster Presenter Spain Influence of imbalanced progesterone receptor isoforms on breast cancer metabolism-related protein expression P-201 EACR25-2118 Luisa A Helguero Poster Presenter Portugal PIK3CA modulates oncogenic and stemness properties in Cervical Cancer P-202 EACR25-2128 RUPA MISHRA Poster Presenter India Luminal breast cancer cell migration is reduced by depletion of BCL6 transcriptional repressor P-203 EACR25-2238 Patr Poster Presenter Portugal Screening for senolytics by live monitoring the cell fate of senescent cancer cells P-204 EACR25-2310 Maayke Kuijten Poster Presenter Netherlands LZTR1 acts as a potent tumor suppressor gene in liver cancer by safeguarding aberrant MAPK activity via posttranslational control of RAS GTPases P-205 EACR25-2336 Peter Macsek Poster Presenter Germany Metabolic Rewiring in Chemoresistant Pancreatic Cancer Redox Metabolism and Lipid Alterations P-206 EACR25-2366 Rossella Mosca Poster Presenter Italy ADDITIVE EFFECT OF EQUOL ON CHEMOTHERAPEUTICS USING 3D BIOPRINTED COLORECTAL CANCER CELLS P-207 EACR25-2416 Diana Molander Poster Presenter Bulgaria Naringenin’s Role in Mitophagy and Apoptosis: A Study in Cancerous and Healthy Cells P-208 EACR25-2434 Emrah Bertan Poster Presenter Turkey Purine Synthesis as a Metabolic Bottleneck in TP53/KRAS Double-Mutant Lung Adenocarcinoma P-209 EACR25-2460 J Poster Presenter Spain Androgen receptor, Filamin A, and CXCR4: partners in crime in TNBC. P-210 EACR25-2474 Pia Giovannelli Poster Presenter Italy Anti-Cancer Effects of Haplophyllum tuberculatum Extract Against Triple Negative Breast Cancer P-211 EACR25-2512 Yusra Saif Al Dhaheri Poster Presenter United Arab Emirates Exploiting inhibitors of histone deacetylase and metabolism for pancreatic cancer therapy P-212 EACR25-2520 Zeribe C. Nwosu Poster Presenter United States Seamless Capture Integration for Accurate NGS-Based Applications P-213 EACR25-2522 Sebastian Celis Poster Presenter Germany DISSECTING THE MOLECULAR MECHANISMS UNDERLYING THE ERKi-ENTRECTINIB COMBINATION IN LKB1-MUTATED NSCLC P-214 EACR25-2536 Caiola ELisa Poster Presenter Italy Mitochondrial dynamics control cancer cell migration P-215 EACR25-2548 Subhajit Dutta Poster Presenter Germany Induction of Chemoresistance through Oxidative Stress and Lipid Reprogramming in Colorectal Cancer Cells Exposed to Adipose Microenvironmentnt P-216 EACR25-2566 Paula de Juan Maci Poster Presenter Spain Type I interferons suppress pancreatic cancer initiation P-217 EACR25-2578 Isabella Del Priore Poster Presenter United States Age-specific factors determine brain metastasis growth and immunotherapy response P-218 EACR25-2598 Charlotte Russell Poster Presenter United Kingdom Description of genomic profiles in non-small cell lung cancer: the particular case of Wnt and NFkB pathways interaction P-218A EACR25-23550 Laura Vali Poster Presenter Spain Preclinical Research on Posterior Fossa Ependymoma Group A: From Experimental Models to Therapeutic Strategies P-161 EACR25-2556 Raimundo Azevedo Vilarouca Neto Poster Presenter Brazil Poster and Exhibition Hall
10:45 20:00	CANCER GENOMICS The expression and clinical significance of serum exosomes miR-122 and miR-874 in patients with colorectal cancer P-219 EACR25-0024 Yong Wang Poster Presenter China Expression of APOC3 in human colon cancer, the clinical and therapeutic value P-220 EACR25-0190 CAI WANG Poster Presenter United Kingdom Characterizing Circulating Tumor Cell and containing Cancer Stem Cell Heterogeneity in Pancreatic Adenocarcinoma: A Single Cell Perspective P-221 EACR25-0270 Berina Sabanovic Poster Presenter Italy Comparative analysis of genomic and clinicopathologic characteristics between multifocal and unifocal breast cancer patients by whole-exome sequencing P-222 EACR25-0314 chungyeul kim Poster Presenter Korea (Republic of) Spatiotemporal multi-omics uncover tumor ecosystem dynamics driving metastatic colonization P-223 EACR25-0336 LIANG WU Poster Presenter China Machine learning-derived mutational signatures reveal distinct DNA repair pathway dysregulation and clinical outcomes in BRCA1/2 ovarian cancer P-224 EACR25-0382 Ionut-Gabriel Funingana Poster Presenter United Kingdom Single-cell analysis reveals tumor-driven immune microenvironment reprogramming that promotes lung adenocarcinoma metastasis. P-225 EACR25-0388 huijuan zhang Poster Presenter United Kingdom Studying genomic evolution in colonic cell line models of mismatch repair deficiency. P-226 EACR25-0494 Zofia Piszka Poster Presenter United Kingdom CRISPR-Cas9 knock-out screening of lncRNAs highlights new therapeutic targets for cancer treatment P-227 EACR25-0498 Ottavio Croci Poster Presenter Italy FUNCTIONAL EXPLORATION THE MOLECULAR MECHANISM OF THE REGULATION FACTORS WHICH ARE RELATED TO THE TUMORIGEN-ESIS AND PROGNOSIS OF COLORECTAL CANCER P-228 EACR25-0522 LIU WEI HUAN Poster Presenter Taiwan Non-canonical ORF Translation in Neuroblastoma: A New Source of Therapeutic Targets? P-229 EACR25-0576 Martina Jovancheva Poster Presenter Netherlands Spatial transcriptomics in precancerous lesions of the colorectum P-231 EACR25-0638 Ma Poster Presenter Sweden Cardiac metastasis: From spatial transcriptomics to targeted therapy P-232 EACR25-0674 Daniela Lorizio Poster Presenter Italy Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer P-233 EACR25-0768 Allan Lui Poster Presenter United Kingdom Recurrent endocervical polyps harbor UBE2A p.(Arg6Trp) mutation P-234 EACR25-0832 Siiri Kev Poster Presenter Finland Core2Edge: A Human Glioblastoma Organoid and Brain Slice Co-Culture Model Capturing Tumor Infiltration and Transcriptional Heterogeneity from Core to Single-Cell Dispersion P-235 EACR25-0848 Ahmad Melhem Poster Presenter Germany Deciphering the Timing of Somatic Driver Mutations in Early-Onset Breast Cancer P-236 EACR25-0856 Bhin Jinhyuk Poster Presenter Korea (Republic of) Metabolic relevance of p53 hotspot mutations in hepatocellular carcinoma P-237 EACR25-0950 Jelena Krstic Poster Presenter Austria Exploring EGLN1 as a therapeutic target for KRAS mutated lung cancer: insights into mitochondrial modulation P-238 EACR25-0986 Alessandra Grieco Poster Presenter Italy Decoding the Molecular Complexity of HCC: Clonal Diversity, Functional States, and Tumor-Stroma Crosstalk P-239 EACR25-1010 INES SIMEONE Poster Presenter Italy Single-cell sequencing analysis highlights the transdifferentiation potential of cancer cells in a neuroblastoma cell line P-240 EACR25-1076 Tomanelli Michele Poster Presenter Italy Dual mutations in ARID1A and PIK3CA drive aggressiveness and drug resistance in estrogen receptor-positive breast cancer P-278A EACR25-1150 Almog Bachar Poster Presenter Israel Same-cell spatial transcriptomics and proteomics expression at single-cell resolution to decipher melanoma cell state heterogeneity and relationships with the inflammatory microenvironment in metastas P-241 EACR25-1164 Madhavi Dipak Andhari Poster Presenter Belgium Integrated multi-omics analysis identifies sex differences in muscle-invasive bladder cancer P-242 EACR25-1200 Jung Min Sung Poster Presenter Korea (Republic of) Comprehensive genomic profiling and RNA-seq analysis reveal distinct genomic and transcriptomic signatures associated with treatment response in metastatic colorectal cancer (mCRC) patients (pts) enrolled in the NIVACOR trial P-243 EACR25-1254 Riziero Esposito Abate Poster Presenter Italy Novel replication stress signature predicts non-homologous end-joining association mediated by the MutSα complex P-244 EACR25-1262 Philipp Jungk Poster Presenter Germany Glucocorticoid receptor as a prognostic factor in triple-negative breast cancer correlates with migratory signature at a single-cell level P-245 EACR25-1290 Attila Pat Poster Presenter Hungary Spatial profiling of matched adnexal and omental tumors in high-grade serous carcinoma P-246 EACR25-1328 Niina Anneli Aho Poster Presenter Finland Phenotypic and genomic characterisation of single micronuclei P-247 EACR25-1334 Jovanna Maharaj Poster Presenter United Kingdom Unraveling the influence of risk factors on tumour evolution in clear cell renal cell carcinoma P-248 EACR25-1340 Olivia Dove Poster Presenter Spain Is it the T-cell to Macrophage Ration that matters for treatment in TNBC P-249 EACR25-1388 Madhura Kulkarni Poster Presenter India Investigating the impact of PRUNE2 deregulation on prostate cancer P-250 EACR25-1392 Andreia Brand Poster Presenter Portugal Unveiling plasma cell–tumor cross-talk to boost immunotherapy in microsatellite-stable colon cancer P-251 EACR25-1436 Belen Martinez Castedo Poster Presenter Spain Spatial Multiomics Reveals T-cell Activation and Exhaustion States in the Tumor Microenvironment  P-252 EACR25-1444 Mathilde Busson Poster Presenter United Kingdom Mutational Signature Profiling in KRAS Mutant Lung Adenocarcinoma: Variant-Specific Associations and Prognostic Implications P-264 EACR25-1448 Laura Woodhouse Poster Presenter United Kingdom Decoding the Complexity of Prostate Cancer Evolution: Uncovering Heterogeneous Cell States by Integrative Approaches P-253 EACR25-1584 Giada Andrea Cassanmagnago Poster Presenter Switzerland Inhibition of the heat shock response enhances modulated electrohyperthermia effects in triple negative breast cancer mouse model P-254 EACR25-1672 Peter Hamar Poster Presenter Hungary Prevalence of Chromosomal Alterations in Acute Leukemias: A Descriptive Analysis in the Colombian Population P-255 EACR25-1694 Rafael Parra-Medina Poster Presenter Colombia Targeting Aurora Kinase A in Breast Cancer Brain Metastasis P-256 EACR25-1740 Damir Vareslija Poster Presenter Ireland Unraveling the role of LKB1 mutations in Non-Small Cell Lung Cancer brain metastasis formation P-257 EACR25-1768 Laureen Sarah Goodman Poster Presenter Israel Genomic profiling of tumour and liquid biopsy melanoma samples with targeted next-generation sequencing P-258 EACR25-1774 Magdalena Olbryt Poster Presenter Poland STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells P-259 EACR25-1830 Dedrick Kok Hong Chan Poster Presenter Singapore Genome-wide CRISPR screen identifies RAB14 as a new target for gastric cancer treatment P-260 EACR25-1840 Ana Catarina Nunes Poster Presenter Portugal Beyond BRAF V600E: Revealing the Hidden Clinical Relevance of Uncharacterized BRAF Variants P-261 EACR25-1892 Dries Vanisterbecq Poster Presenter Belgium Intra-Tumour Heterogeneity in Cutaneous Squamous Cell Carcinoma Assessed by Spatial Transcriptomics P-262 EACR25-1894 Paranita Ferronika Poster Presenter The landscape of copy number intra-tumour heterogeneity in breast cancer and its impact on the tumour ecosystem P-263 EACR25-1942 Callari Maurizio Poster Presenter Italy Microhomology-Driven Genomic Alterations in Ovarian Cancer P-912 EACR25-2024 Daria Kostka Poster Presenter Poland Mapping Therapeutic Opportunities in LUSC Through Targeted Compound Screening P-265 EACR25-2038 Andrada Teodora Iovi__ Poster Presenter Romania Exposing G2/M Checkpoint Vulnerabilities: BUB1B and BUB3 as Essential Dependencies in Malignant Pleural Mesothelioma P-266 EACR25-2106 Ebru K Poster Presenter Turkey Deciphering oncogenic gene regulatory mechanisms at nucleotide resolution using precision genome editing P-267 EACR25-2186 Juuli Hietarinne Poster Presenter Finland Common Genetic Dependencies of Sonic Hedgehog Medulloblastoma (SHH-MB) variants are Regulated by the Non-Malignant Microenvironment P-268 EACR25-2252 John Jacob Poster Presenter United Kingdom GEM-X Flex: Scalable and cost-effective whole transcriptome single cell analysis for cancer marker detection from FFPE tissue section slides P-269 EACR25-2348 Tingsheng Yu Drennon Poster Presenter United States Advancing tumor characterization and immune phenotyping through multiomic in situ profiling of RNA and proteins P-904 EACR25-2350 Extensive spatial heterogeneity of transcript variants in localised prostate cancer P-270 EACR25-2380 Susanne G. Kidd Poster Presenter Norway Spatial transcriptomic insights into the influence of cancer-associated fibroblast profiles in oral cancer spheroids P-271 EACR25-2382 Leonardo Rocha Poster Presenter Brazil Optimizing low input and high-throughput cell fixation for single-cell RNA sequencing with combinatorial barcoding P-272 EACR25-2446 Gokhan Demirkan Poster Presenter United States Heterogenous fusion transcript landscape in multifocal primary prostate cancer P-273 EACR25-2452 Ane Stranger Poster Presenter Norway Unraveling chemoresistance in breast cancer through circulating miRNAs in liquid biopsy P-274 EACR25-2468 Romero Sandra Poster Presenter Mexico The TP53:AHR genetic interaction regulates MAGE:TRIM28 activity to prevent cellular transformation P-275 EACR25-2494 Dorothea Maneta Poster Presenter Germany Sex-Dependent Transcriptional Gene Expression in Urothelial Bladder Cancer P-276 EACR25-2496 Ayse Nur Myumyun Poster Presenter United Kingdom Spatial Transcriptomics for characterising pathologic response to FOLFOX regimen in colorectal Liver Metastases P-277 EACR25-2564 Natalia Molina Poster Presenter Spain Genomic Analysis of PARP Inhibitor Response in High-Grade Serous Ovarian Cancer: Insights from Whole Genome Sequencing P-278 EACR25-2592 Hyerim Eum Poster Presenter Korea (Republic of) Poster and Exhibition Hall
10:45 20:00	CARCINOGENESIS Unravelling the role of AP-1 transcription factor in DNA damage signalling and response (DDR), platinum and PARP inhibitor resistance in ovarian cancers P-279 EACR25-0022 Shatha AlQahtani Poster Presenter United Kingdom Targeting Replication Protein A (RPA) heterotrimeric complex to enhance platinum sensitivity and reverse PARP inhibitor resistance in ovarian cancers P-280 EACR25-0044 Mashael Algethami Poster Presenter United Kingdom Translational control in ovarian cancer: role of the glutaminyl-tRNA synthetase (QARS) in DNA damage response P-281 EACR25-0170 Martina Serafini Poster Presenter France Fibronectin leucine-rich transmembrane protein 3 is a potential driver of intrahepatic cholangiocarcinoma P-282 EACR25-0802 Lara Prates Poster Presenter Belgium The inter-relationship between arsenic exposure and oxidative stress biomarkers on the risk of cancer occurrence - A population-based cohort study P-283 EACR25-1000 Kuang-Hung Hsu Poster Presenter Taiwan Alterations in laminin alpha2-chain impact melanoma progression P-284 EACR25-1580 Vanessa Ribeiro Poster Presenter Portugal Weaponizing the CRISPR/Cas9 technology P-285 EACR25-1614 Sara Tavella Poster Presenter Italy Development of an ex vivo model to determine early transcriptional changes in breast cancer P-286 EACR25-1790 Harry Barnes Poster Presenter United Kingdom A synergistic effect of RNF43 and BRAF mutations on colorectal carcinogenesis P-287 EACR25-1796 Alexandra Bauche Poster Presenter Germany Investigating the carcinogenic and epigenetic modulating effects of per- and poly-fluoroalkyl substances (PFAS) on breast cancer development P-288 EACR25-2276 Lucie Bilton Poster Presenter United Kingdom Obesity-Derived Circulating Extracellular Vesicles Promote Tumor-Stimulatory Functions of Stromal Fibroblasts in Breast Cancer P-289 EACR25-2282 Piercarlo Del Console Poster Presenter Italy Sex differences in selection of somatic mutations in normal human bladder P-290 EACR25-2384 Raquel Blanco Poster Presenter Spain Poster and Exhibition Hall
10:45 20:00	DRUG RESISTANCE Three- dimensional (3D) Cancer Microenvironment that Confers Chemoresistance to DNA Damaging Drug P-291 EACR25-0208 Jue Shi Poster Presenter Hong Kong, China Targeted Delivery of NVPBEZ235 conjugated to gold nanoparticles for Overcoming Gemcitabine Resistance in Triple-Negative Breast Cancer P-292 EACR25-0218 _uranur Ayvaz Poster Presenter Turkey In Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer P-293 EACR25-0278 Carlos Fernandez-Lozano Poster Presenter Spain A newly discovered mTOR-STAT3 pathway regulates calcium release and calcium-mediated apoptosis at the ER in Triple Negative Breast Cancer P-295 EACR25-0456 Daniele Viavattene Poster Presenter Italy Evaluate the potential sensitization effect and underlying mechanism of tyrosine kinase inhibitor on cisplatin resistance oral squamous cell carcinoma P-296 EACR25-0566 Ying-Tzu Chen Poster Presenter Taiwan Study of long non-coding RNAs in resistance to KRAS G12C inhibitors in lung cancers P-297 EACR25-0574 Thomas PAPAZYAN Poster Presenter France Targeting the Non-Homologous End-Joining Pathway Sensitizes MDM2-Amplified Liposarcoma to Doxorubicin-Induced Senescence in a p53-dependent Manner P-298 EACR25-0592 Thijs Jalving Poster Presenter Netherlands Regulation of FOXK2 by AKT in breast cancer cells: Serine 398 as a novel potential phosphorylation site P-299 EACR25-0598 Luciana da Torre Carneiro Poster Presenter Brazil FOXK2 transcription factor in cancer: expression, function and potential as a biomarker P-300 EACR25-0600 Renata Ivo Vasconcelos Poster Presenter Brazil Targeting low fidelity polymerases to prevent acquired resistance mutations to EGFR-targeted therapy in lung cancer. P-301 EACR25-0764 Marieke Van Daele Poster Presenter Israel Inhibition of the extracellular signal-regulated kinase 5 (ERK5) increases EGFR expression and its nuclear localization in HCC, generating new targeting opportunities P-302 EACR25-0984 Alessio Menconi Poster Presenter Italy mTORC1 Fuels Resistance but Unlocks Metabolic Kill-Switch in PI3K-Mutant Breast Cancer P-303 EACR25-1238 Alina Stroh Poster Presenter Germany Assessment of two new ROS1+ NSCLC patient-derived cell lines as in vitro models for TKI resistance studies P-304 EACR25-1298 Christa Dijkhuizen Poster Presenter Netherlands Discovery of Molecular and Epigenetic Candidates Underlying Chemoresistance of Colorectal Cancer P-305 EACR25-1344 Saba Selvi Poster Presenter Czech Republic The mechanism of PPARα-mediated cholesterol metabolism in regulating paclitaxel resistance in ovarian cancer cells P-306 EACR25-1350 Mingzhuo Chen Poster Presenter China AP-1 transcription factor is a targetable mediator of osimertinib resistance in EGFR-mutant non-small cell lung cancer P-307 EACR25-1424 Sude Eris Poster Presenter Turkey Overactivation of oncogenic signaling steers cancer cells toward less malignant phenotypes P-308 EACR25-1446 Chrysa Papagianni Poster Presenter Netherlands CIC: The Master Regulator of Resistance to MAPK Pathway Inhibition P-309 EACR25-1480 Joao Neto Poster Presenter Netherlands Unlocking New Therapies: Targeting GSDMB Overexpression in HER2-Positive Tumors P-310 EACR25-1572 Carmen Ramos Nebot Poster Presenter Spain FGFR signaling as a key mediator of resistance to alpelisib/fulvestrant combination in PIK3CA-mutant luminal A breast cancer P-311 EACR25-1592 Melda Ozge Oguz Poster Presenter Turkey Targeting Ferroptosis to Enhance the Efficacy of BRAF/MEK Inhibitors in Overcoming Resistance in Melanoma P-312 EACR25-1612 Juan Antonio Fafian Labora Poster Presenter Spain Investigation of the expression of drug resistance genes after Sorafenib administration P-313 EACR25-1622 IPEK ECE KOCKAR Poster Presenter Turkey Targeting CCL19/21-CCR7 axis to overcome resistance to ALK inhibitors in ALK+ lymphoma P-314 EACR25-1644 Mariapia Russo Poster Presenter Italy T-cell receptor (TCR) diversity in buffy coat samples from blood of ovarian, vulvar squamous cell and cervical cancer patients P-294 EACR25-1656 Corinna Keup Poster Presenter Germany Genomic Instability and Epigenomic Dysregulation as Hallmarks of mCRC Therapy Resistance — Findings from Broad ctDNA Molecular Profiling (METACC) P-315 EACR25-1664 Camblor Daniel G. Poster Presenter Spain Exploring potential strategies overcoming the PARPi resistance in the Olaparib induced MDA-MB-436 resistant model P-316 EACR25-1698 FEIFEI FEI FAN Poster Presenter China BMI1 as a therapeutic target to overcome chemoresistance in high-grade serous ovarian cancer P-317 EACR25-1980 Sadia Zafar Poster Presenter Finland Identification of microRNAs and their target genes associated with acquired resistance of primary melanoma cells to targeted therapy P-318 EACR25-2034 Ignacija Vla_i_ Poster Presenter Croatia Impact of Mechanical Stress and Confinement on the Alteration of Protein Expression and Emergence of Time-Dependent Resistance to Cisplatin P-319 EACR25-2042 Yasmin Antonelli Poster Presenter Germany Uncovering Transcriptional Signatures of Differential Drug Response in Archetypical Malignant States in Metastatic Breast Cancer (MBC) P-320 EACR25-2062 Hodaya Haimov Poster Presenter Israel Overcoming P-glycoprotein-mediated resistance in tumor cells through copolymers for cytotoxic drug delivery P-321 EACR25-2102 Milada _ Poster Presenter Czech Republic Dual targeting BRD4-CDK9 transcriptional complex as a potent therapeutic strategy in glioblastoma P-322 EACR25-2108 Raquel L Poster Presenter Spain Unraveling mechanisms of CDK4/6 inhibitors resistance in metastatic breast cancer P-323 EACR25-2112 Irina Suheila Fonseca Poster Presenter Spain Immune infiltration is associated with favorable response to neoadjuvant chemotherapy and carboplatin in hormone receptor positive and triple negative breast cancer P-324 EACR25-2246 Eivind Valen Egeland Poster Presenter Norway Inhibition of the RNA-binding protein HuR reduces cell proliferation and promotes apoptosis in EGFR-TKI resistant NSCLC cells P-325 EACR25-2270 Annarita Cascone Poster Presenter Italy Targeting PI3K/AKT Pathway Dysregulation in Triple-Negative Breast Cancer: Overcoming Alpelisib Resistance through Dual Inhibition P-326 EACR25-2322 Grace Colley Poster Presenter Ireland Endothelial-Derived CAFs Drive Chemoresistance via ERCC1-IL-17A Axis: A Novel Therapeutic Target in Tumour Microenvironment P-327 EACR25-2390 Katarzyna Sobierajska Poster Presenter Poland miR-181a-5p and Caveolin-1 Express Inversely in HCC and Augment the Aggressive Phenotype of Sorafenib-Resistant HCC Cells P-328 EACR25-2410 Ezgi Bagirsakci Poster Presenter Turkey Overcoming Taxane Resistance Through PRMT5 Inhibition: Targeting Epigenetic Mechanisms P-329 EACR25-2458 Ezgi Karyemez Poster Presenter Turkey Unraveling tumor intrinsic responses: IFN-gamma predicts clinical immunotherapy efficacy and exclusively triggers apoptosis in solid tumors while sparing hematologic malignancies P-330 EACR25-2546 Iris Garrido-Cano Poster Presenter Spain Signaling Pathways affected by RAGE inhibition in vemurafenib treated melanoma cells P-331 EACR25-2550 Estelle Leclerc Poster Presenter United States Berberine, a P-glycoprotein inhibitor, shows synergistic anti-cancer effect when combined with Dactolisib in Colorectal Carcinoma HCT116 cell lines P-332 EACR25-2572 Zeynep Busra Bolat Poster Presenter Turkey ELUCIDATING TOPOTECAN-RESISTANCE MECHANISM IN HUMAN BREAST MCF-7 CANCER CELLS AND PACLITAXEL CROSS-RESISTANCE BY DNA DAMAGE SIGNALING PATHWAY GENE EXPRESSION. P-332A EACR25-24950 Erika Guerrero Poster Presenter Panama Poster and Exhibition Hall
10:45 20:00	EPIGENETICS An epigenetic shift of CEMIP drives tumor metastasis and 3D spheroid fomation in Androgen-resistant prostate cancer P-333 EACR25-0114 Ms. Salida Ali Poster Presenter The effectiveness of EZH2 inhibitors in treating human papillomavirus associated cervical cancer and associated pathways P-334 EACR25-0284 Dora Vidalina Poster Presenter United Kingdom Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. EACR25-0612 EACR25-0612 Ryan Hull Poster Presenter United Kingdom Correlation with DNA methylation changes and chemoresistance in glioblastoma after mitochondiral transfer P-335 EACR25-0720 Tsz Yee Ng Poster Presenter Hong Kong, China EZH2 regulates cell identity in neuroendocrine-like prostate cancer by driving alternate transcription via activation of translation and RNA processing regulation. P-336 EACR25-0746 Beatriz German Falcon Poster Presenter United States Unraveling Inflammation-Related microRNAs in Pleural Mesothelioma: Gene Regulation and Pathway Analysis P-337 EACR25-0800 Giulia Tonnini Poster Presenter Italy Promoter methylation regulates CDHR5 and UPB1 expression in clear cell Renal Cell Carcinoma with sarcomatoid differentiation P-338 EACR25-0822 Carmen Jer Poster Presenter Methylation profiles in cervical swabs: challenges in early diagnosis of ovarian cancer P-339 EACR25-0978 Edyta Biskup-Schmoller Poster Presenter Denmark IRF2BP2/TRIM28/DNMT1 suppresses transposable elements to maintain AML survival P-340 EACR25-1064 Jingru Xu Poster Presenter United Kingdom KDM6A Regulates Sex Specific Immune Responses in Melanoma. P-341 EACR25-1176 Jessamy Tiffen Poster Presenter Australia Multi-omics Study Identified Novel Oncogenic Roles of DNA-interacting Circular RNA as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma P-342 EACR25-1194 Chi Hin Wong Poster Presenter Hong Kong, China Molecular profiling of uncharacterized Sex Cord-Stromal Tumors of the Ovary P-900 EACR25-1330 Carla Roca Poster Presenter Spain High-throughput DNA methylation profiling of urological malignancies: defining epigenetic signatures in prostate, bladder and kidney cancers P-343 EACR25-1336 Vera Const Poster Presenter Portugal Epigallocatechin-3-gallate as a potential epigenetic regulator of ALDH1 expression in colorectal cancer P-344 EACR25-1432 Nikoleta Mojzesov Poster Presenter Slovakia Unraveling MLH1 promoter methylation and CpG Methylator Phenotype interplay in colorectal adenocarcinoma P-345 EACR25-1464 Carlotta Ceccon Poster Presenter Italy Metabolic deregulation of TET/TDG DNA demethylation complex impairs base excision repair process promoting PDAC tumorigenesis P-346 EACR25-1496 Francesco Spallotta Poster Presenter Italy EZH2 inhibition: A Key to Unlocking the Notch-Driven Tumor Suppression in Acute Myeloid Leukemia P-347 EACR25-1546 Eleonora Pace Poster Presenter Italy Promoter methylation identifies potential biomarkers for early detection of colitis-associated cancer P-348 EACR25-1686 Biancastella Cereser Poster Presenter United Kingdom Multiomics assessment of lung adenocarcinoma subtypes defined through tumor purity-adjusted DNA methylation P-349 EACR25-1754 Elsa Arbajian Poster Presenter Sweden Arid1a directs lineage specification in mammary epithelial cells P-350 EACR25-1838 Estelle Deby Poster Presenter Switzerland Targeting CBX2 disrupts DNA damage repair and mitosis regulation in glioblastoma – a novel therapeutic opportunity P-351 EACR25-1900 Danielle Marsh Poster Presenter United Kingdom Integrative Multi-Omic Analysis Reveals a Pax8-Driven Gene Network Linking Tumor Stemness to Therapy Response in Ovarian Cancer. P-352 EACR25-2096 Sandra Mu Poster Presenter Spain Functional impact of histone methyltransferase KMT2B in pediatric astrocytomas P-353 EACR25-2204 Angeliki-ioanna Giannopoulou Poster Presenter Greece Poster and Exhibition Hall
10:45 20:00	EXPERIMENTAL / MOLECULAR THERAPEUTICS, PHARMACOGENOMICS Chromenone Derivatives as Potential CRM1 Inhibitors for Glioblastoma Therapy P-354 EACR25-0068 Cristiana Mourato Poster Presenter Portugal IQS080 is a novel cytosolic multitargeted kinase inhibitor that simultaneously targets key kinase families, making it a promising candidate for the treatment of pancreatic cancer P-355 EACR25-0084 Alberto Villanueva Poster Presenter Spain Engineering Bacteriophages for Targeted Photodynamic Cancer Therapy P-356 EACR25-0086 Alena Kaltenbrunner Poster Presenter Italy The anthelmintic drug rafoxanide promotes oxidative stress and VDAC1 opening, leading to mitochondrial dysfunction in colorectal cancer cells. P-357 EACR25-0132 Federica Laudisi Poster Presenter Italy The synergistic effect of sedanolide and 5-fluorouracil on triggering mitochondria-dependent apoptosis in colorectal cancer cells P-358 EACR25-0194 Chih-Chung Wu Poster Presenter Taiwan The interplay between melatonin and alpha-synuclein on melanoma biomolecular signatures P-359 EACR25-0202 Panagiota S. Filippou Poster Presenter Greece The anti-cancer activity of novel diazo-derived compounds on triple-negative breast cancer P-360 EACR25-0220 Ayse Busranur Celik Poster Presenter Turkey Enhanced Efficacy and Targeted Delivery System of a pH-sensitive ARV-825 Nanomedicine for Glioblastoma Treatment P-361 EACR25-0228 HIroaki Kinoh Poster Presenter Japan A genetic signature predicts the response of aggressive paragangliomas to dual PI3K and CDK4/6 inhibition. P-362 EACR25-0326 Bhargavi Karna Poster Presenter Germany PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors P-363 EACR25-0410 Ling-hua Meng Poster Presenter China Oxyresveratrol inhibits the tumorigenesis and metastasis of human HCC cells by targeting the CCDC19/PLK1/CCNB1 pathways P-364 EACR25-0414 Hui-Ling Chiou Poster Presenter Taiwan Integrative Pharmacogenomics in RCC Tumoroids Uncovers Biomarker-Driven Combination Therapies P-365 EACR25-0450 Tianyi Chen Poster Presenter China Targeted Delivery of Extracellular Vesicles to Metastatic Breast Cancer Cells Using the Tumor-Targeting Peptide p28 P-366 EACR25-0490 Pedro Gon Poster Presenter Portugal Modulation of GPR55 and PINK1 in Glioblastoma Multiforme Models by Cannabis sativa and Piper nigrum Metabolites P-367 EACR25-0516 andres david turizo smith Poster Presenter Colombia Repurposing the antifungal piroctone olamine as a targeted treatment for pancreatic ductal adenocarcinoma P-368 EACR25-0532 Sharon Prince Poster Presenter South Africa Discovery of DAC-1522, a novel Trop2-targeting degrader-antibody conjugate for precision oncology P-369 EACR25-0618 XUAN ZHANG Poster Presenter China Punicalagin-mediated suppression of oncogenic properties in ovarian epithelial adenocarcinoma cells P-370 EACR25-0622 Zeeshan Ahmad Bhutta Poster Presenter Korea (Republic of) Risk and benefit for basket clinical trials in oncology: a systematic review with meta-analysis P-371 EACR25-0640 Karolina Strzebonska Poster Presenter Poland Exploring the Cytotoxic Potential of Calcite on MCF-7 Cells: A Promising Approach for Breast Cancer Treatment P-372 EACR25-0642 Akansha Kothidar Poster Presenter India Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects P-373 EACR25-0660 Youhong Hu Poster Presenter China Investigating the Antitumour Potential of Fucoidan with Everolimus: An in vitro and in vivo Study Focusing on ERα/Akt/mTOR Pathway Suppression P-374 EACR25-0718 Maha Ramadan Amin Abdollah Poster Presenter Egypt High-Throughput Screening Identifies Novel Small Molecule Inhibitors of ELP3 with Potent Anti-Cancer Activity In Vivo P-374A EACR25-0744 DANIELE CARETTONI Poster Presenter Italy Novel Tamoxifen Derivatives Suppress Breast Cancer Growth and Alter Cancer-Related Gene Expression P-375 EACR25-0762 Irem Durmaz Sahin Poster Presenter Turkey A novel ribosome biogenesis inhibitor, PMR-116, displays broad spectrum efficacy in preclinical tumour models P-376 EACR25-0930 Luc Furic Poster Presenter Australia Nanobiotechnological engineering of M13 bacteriophage for EGFR-targeted theranostics P-377 EACR25-1022 Paolo Emidio Costantini Poster Presenter Italy KA103, a novel targeted toxin for Head and Neck Cancer P-378 EACR25-1032 Castaneda Zegarra Sergio Miguel Poster Presenter Norway Evaluation of the antineoplastic effects of imipridone derivatives in prostate cancer: Novel therapeutic opportunities P-379 EACR25-1052 Fatima Ghamlouche Poster Presenter Lebanon Incorporation of disulfide bond into interleukin-2 for enhancing stability, solubility and therapeutic efficacy P-380 EACR25-1056 Woei-Jer Chuang Poster Presenter Taiwan In vivo delivery of gemcitabine through HPMA copolymer conjugates: slow drug release kinetics is crucial for potent antitumor activity P-381 EACR25-1060 Marek Kovar Poster Presenter Czech Republic Zebrafish Avatar-test predicts tumor response to chemotherapy in Breast Cancer: A co-clinical study for personalized medicine P-382 EACR25-1072 Raquel Valente Mendes Poster Presenter Portugal Effect of RID-A proteins in cachexia and tumor metabolism P-383 EACR25-1110 Marta Fornaro Poster Presenter Italy Targeting BCKDK to Overcome Paclitaxel Resistance in Breast Cancer: A Novel Therapeutic Approach P-384 EACR25-1112 Gehad Mahmoud Iraqy Mohamed Poster Presenter United Kingdom Datopotamab deruxtecan plus PARP inhibition is highly synergistic in 2D and 3D ovarian cancer models P-385 EACR25-1144 Luna Stockmann Poster Presenter Ireland Targeted Treatment of Solid Tumors with BRAF Fusions P-386 EACR25-1186 Joseph Samuel Poster Presenter Canada Long-term organoids derived from head and neck and ovarian cancer patients closely recapitulate tumor of origin and predict clinical outcome P-387 EACR25-1204 Louis-Bastien Weiswald Poster Presenter France Assay development for addressing drug resistance mediated by fibroblasts in ER+ breast cancer P-388 EACR25-1242 Elisabet Rodr Poster Presenter Sweden Anisomelic Acid Suppresses HPV-Driven Tumor Growth with Potential TEAD2 Targeting: Evidence from a Xenograft Model and Proteomics P-389 EACR25-1246 Navid Delshad Poster Presenter Finland PTPN2/PTPN1 inhibition induces tumor eradication in ALK-positive lymphoma by triggering a combination of ALK-induced oncogenic stress and immune responses P-390 EACR25-1302 Marta Rubin Poster Presenter Italy The Superior Therapeutic Potential of Curcumin-Loaded Zinc Oxide Nanoparticles Against Bladder Cancer P-391 EACR25-1318 Zahraa Salhab Poster Presenter Lebanon Biological Basis for the Development of CPL410005 as an Antibody-Drug Conjugate P-392 EACR25-1342 Filip Mitu_a Poster Presenter Poland HSPGs targeting and multimeric cytotoxic conjugates as a novel PDC strategy against pancreatic cancer P-393 EACR25-1374 Krzysztof Ciura Poster Presenter Poland Teaching cells the drug uptake – rational modulation of endocytosis for precise delivery of novel HSPGs targeting conjugate into pancreatic cancer cells P-394 EACR25-1376 Aleksandra Chor__ewska Poster Presenter Poland Expression analysis of CTLA-4, PD-1, and PD-L1 in non-small cell lung cancer patients receiving immunotherapy P-395 EACR25-1378 David Bonnel Poster Presenter Apoptotic Effects of a Flavone Combination on Brain Metastatic Triple-Negative Breast Cancer Cells P-911 EACR25-1382 María Losada-Echeberría Poster Presenter Spain Integrating Proximity Ligation Assay for PD1-PDL1 Immunoassay with Multiplex Immunofluorescence Imaging in Urothelial Carcinoma P-397 EACR25-1400 Tony Ullman Poster Presenter Sweden Type I and II BIR domains as targets for cancer therapy P-398 EACR25-1412 Federica Cossu Poster Presenter Italy Alpha-1 adrenergic antagonists to sensitize neuroblastoma over isotretinoin theraphy P-399 EACR25-1416 Francesca Broso Poster Presenter Italy Muscle-invasive bladder cancer organoids as a functional system to address therapy response: Perspective in advancing precision medicine P-400 EACR25-1434 Haiyan Yue Poster Presenter Switzerland MESOPOROUS SILICA NANOPARTICLES FOR THE SELECTIVE DELIVERY OF DOXORUBICIN TO FOLATE RECEPTOR-EXPRESSING CANCER CELLS P-401 EACR25-1450 Catia MORELLI Poster Presenter Italy Targeting UBE2N with Novel Non-Covalent Inhibitors: A Drug Discovery Approach to Combat PARPi Resistance in Ovarian Cancer P-402 EACR25-1458 Shafi Ullah Khan Poster Presenter France Multimodal targeting of Ephrin A2 in solid tumors using bi-cyclic drug conjugates P-403 EACR25-1466 Laura Diaz Gil Poster Presenter United Kingdom Tackling Hepatocellular Carcinoma with novel PROTAC Degraders of eIF6 P-404 EACR25-1474 Giorgia Tempra Poster Presenter Italy A titanocene-derivative complexed with a myristic-like aliphatic chain exhibits antitumor activity in cisplatin-resistant models both in vitro and in vivo P-405 EACR25-1484 Marta Guadamillas Poster Presenter Spain EGFR-STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1-positive prostate cancer P-430 EACR25-1490 Elsa Gomes Paiva Poster Presenter Portugal Targeting CITK in high-grade brain tumors: a comparison of polypharmacological and specific inhibitors P-406 EACR25-1518 Alessia Ferraro Poster Presenter Italy Development of Lipid-Based Gene Delivery Systems for CAR T Cell Therapy P-407 EACR25-1520 Margarida Guerreiro Poster Presenter Portugal Oral liquid crystalline dispersion effect in chemotherapy-induced intestinal mucositis P-408 EACR25-1600 Raquel Silva Ara Poster Presenter Brazil Microneedle-mediated delivery of Iron Oxide Nanoparticles & Oxaliplatin with immune checkpoint inhibitors for its induction of ferroptosis and immunomodulation in Head and neck squamous cell carcinoma P-409 EACR25-1702 Debabrata Tripathy Poster Presenter India Targeting RRM2: A Dual Approach to Apoptosis and Cell Cycle Control in Atypical Teratoid Rhabdoid Tumors P-410 EACR25-1710 CHE-CHANG CHANG Poster Presenter Taiwan ALDH1 Isoform Landscape in Breast Cancer: Advancing Precision Therapies with a Potent ALDH1A3-Selective Inhibitor P-411 EACR25-1764 Andrada Constantinescu Poster Presenter France AI and physics based methods to design biopharmaceuticals to fight triple-negative breast cancer P-412 EACR25-1772 Catarina Tavares Cavaleiro Poster Presenter Portugal GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells P-413 EACR25-1780 Lidia Atencia Taboada Poster Presenter Netherlands Mechanistic Insights into the Uptake, Trafficking, Drug Release, and Cytotoxic Efficacy of 5-FU/Irinotecan-Loaded core@shell Nanoparticles in Colorectal Cancer P-414 EACR25-1788 Dolma Choezom Poster Presenter Germany A novel gene therapy combination targeting non-small cell lung cancer P-415 EACR25-1814 Nathan Vella Poster Presenter Malta Organ-on-chip platforms for assessing fasting-driven therapeutic responses in dynamic 3D tumor models P-416 EACR25-1832 SILVIA SCAGLIONE Poster Presenter Oncofetal Chondroitin Sulfate represents a Target for Antibody Drug-Conjugate therapy of Acute Myeloid Leukemia P-417 EACR25-1836 Joana Mujollari Poster Presenter Denmark Engineering Subtype-Specific Breast Cancer Models: Decellularized ECM-Based Bioinks for Organoid Culture and Precision Oncology P-418 EACR25-1858 Juan Antonio Marchal Poster Presenter Spain Targeted drug delivery with erythrocyte-derived nanovesicles in an organ-on-chip tumor model P-419 EACR25-1860 SILVIA SCAGLIONE Poster Presenter Extracellular Vesicles Loaded with miRNAs Target LCP-1 to Inhibit Tumor Growth and Metastasis in Triple-Negative Breast Cancer P-420 EACR25-1954 Marianna Prokopi Poster Presenter Cyprus Defining Docetaxel’s Antitumor Effects on Calu3 Lung Cancer Cells Using High-Throughput Live-Cell Imaging P-421 EACR25-1972 Svenja Meiler Poster Presenter Combination of PARP Inhibitor Olaparib and a Vascular Disrupting Agent Reduces Tumor Growth in a Xenograft Mouse Model of Prostate Cancer P-422 EACR25-1992 Evangelia Sereti Poster Presenter Sweden Cellular response triggered by anticancer agent, C-2028 in breast cancer cells with different expression of key receptors under normoxia and hypoxia conditions P-423 EACR25-2000 Aleksandra Pa_ka Poster Presenter Poland Polyoxovanadates with Anti-breast Cancer Activity and Ca2+-ATPase Inhibition Potential P-424 EACR25-2028 Manuel Aureliano Poster Presenter Portugal Enhancing Therapeutic Efficacy in Patient-Derived Models of Pancreatic Ductal Adenocarcinoma Using Engineered Placental Mesenchymal Stromal Cells P-425 EACR25-2036 Laura Drndakova Poster Presenter Slovakia Investigation of Novel Duocarmycin Payloads Antibody-Drug Conjugates (ADCs) targeting HER2 for Therapeutic Intervention P-426 EACR25-2066 Enric Arasanz Picher Poster Presenter United Kingdom Triptonide induces pro-apoptotic effects against medulloblastoma subtypes P-427 EACR25-2084 Marriam Yaqoob Poster Presenter United Kingdom Doxorubicin and cGAMP-loaded hypoxia-sensitive polymersomes: A strategy for enhanced tumor growth inhibition and reduced systemic toxicity P-428 EACR25-2098 Ryszard Smolarczyk Poster Presenter Poland The effects of a dual GIP/GLP-1 receptor agonist, Tirzepatide, on the response of prostate cancer cells to therapy P-429 EACR25-2140 Haonan Li Poster Presenter United Kingdom Exploring Polyoxotungstates as Novel Antitumor Agents for Pancreatic Cancer Therapy P-431 EACR25-2150 Maria Filomena Botelho Poster Presenter Portugal Investigating the repurposing potential of cardiometabolic and hormonal medications for breast and ovarian cancer treatment using Mendelian randomisation P-432 EACR25-2164 Tessa Bate Poster Presenter United Kingdom Overcoming Gemcitabine Chemoresistance in PDAC with Nanoparticle-Delivered Active Phosphorylated Gemcitabine P-433 EACR25-2172 Nathalia Ferreira Poster Presenter Germany Combinations of HDAC and KRAS inhibitors in lung cancer P-434 EACR25-2208 Jingyu Li Poster Presenter Germany Subcutaneous controlled release of antibodies and antibody-drug-conjugates with zwitterionic chitosan-based hydrogels P-435 EACR25-2248 Guillaume Jacquot Poster Presenter France Effect of doxorubicin and quercetin combined treatment on osteosarcoma model systems P-436 EACR25-2268 Milena Milivojevic Poster Presenter Serbia Unlocking the Dual Power of miR-302b in BRCA1 Wild-Type Triple-Negative Breast Cancer: PARP Inhibitor Sensitivity Enhancer and Tumor Microenvironment Shaper P-437 EACR25-2280 Valentina Fogazzi Poster Presenter Italy Targeted Metabolomics for Early-Onset Colorectal Cancer: Identification of Novel Therapeutic Targets and Biomarker-Driven Treatment Strategies P-910 EACR25-2338 María Losada-Echeberría Poster Presenter Spain MASLiN as hydrophobic anticancer drug carrier: in vitro activity and in vivo biodistribution P-439 EACR25-2358 Juan Antonio Marchal Poster Presenter Spain Photodynamic therapy with ring-fused chlorins: a vision-preserving approach for retinoblastoma treatment P-441 EACR25-2362 Mafalda Laranjo Poster Presenter Portugal Exploring the impact of photodynamic therapy conditioning on endometrial cancer cells P-442 EACR25-2370 Mafalda Laranjo Poster Presenter Portugal The m6A RNA modification sustains neuroblastoma tumor aggressiveness P-443 EACR25-2388 Denise Sighel Poster Presenter Italy Evaluation of the effect of novel fascin inhibitors in patient-derived colorectal cancer organoids considering molecular and histological characteristics P-906 EACR25-2400 Marketa Pavlikova Poster Presenter Spain Cold Atmospheric Plasma as a Potential Strategy to Target the Invasion and Metastasis Hallmark in Breast Cancer P-444 EACR25-2418 Mafalda Laranjo Poster Presenter Portugal Harnessing DNA repair to enhance therapy efficacy in myeloid leukemia: The impact of chronotherapy P-445 EACR25-2428 Joana Jorge Poster Presenter Portugal Expression profiles of target genes for approved antibody-drug conjugates in the context of high-grade serous carcinoma P-446 EACR25-2462 Elsi Pauliina P Poster Presenter Finland Alpha-aminobutyric acid attenuates DEN and diet-induced MASLD/MASH mice model by suppression of oncogenic signalling pathways KRAS, STAT3 via gut microbiome modulation P-447 EACR25-2568 Felicianna Felicianna Poster Presenter Hong Kong, China Combined siRNA targeting of oncogenic NRAS and BRAF drivers as a strategy for mole reversal and melanoma prevention P-447A EACR25-15870 Phoebe Antonia Jones Poster Presenter United Kingdom Poster and Exhibition Hall
10:45 20:00	IMMUNOTHERAPY Novel Antibody Therapeutics: Anti-BCMA.ECD for Personalised Cell Therapy in Multiple Myeloma P-448 EACR25-0072 Gunjan Dagar Poster Presenter India DLL3-targeting CAR-T cells enhanced by co-deletion of PD1 exhibit better efficacy and persistence in a pre-clinical animal model for small cell lung cancer P-449 EACR25-0102 Hua Zhang Poster Presenter Hong Kong, China Fishing for new immunotherapy compounds to boost innate-tumor rejection P-450 EACR25-0448 Ana Beatriz Machado Poster Presenter Portugal Preclinical double humanized CD47/SIRPα mouse model and MC38 cell line expressing human CD47 for efficacy and safety assessment of anti-CD47/SIRPΑ-targeting therapies P-451 EACR25-0518 Fabiane Sonego Poster Presenter France Development of the in vitro 3D Spheroid High-Throughput Screening Platform for the Development of Immune Checkpoint Inhibitors P-452 EACR25-0586 Michal Rudnik Poster Presenter Switzerland Integrating the Fasting-Mimicking Diet to Augment Anti-tumor Immunity following Adoptive Cell Transfer in Breast Cancer. P-453 EACR25-0656 Evangelia Pavlou Poster Presenter Italy ROR1-Specific CAR T-Cells: Advancing Targeted Immunotherapy for Cancer P-454 EACR25-0710 Adrian-Bogdan Tigu Poster Presenter Romania Improved Adoptive T Cell Therapies for Colorectal Liver Metastases by Stabilization of IFNAR1 on Tumor-Specific T-Cells P-455 EACR25-0726 Andrea Castiglioni Poster Presenter Italy A Pro-Tumorigenic Cytokine with an Unexpected Anti-Cancer Role: TGFβ Enhances NK cell Immunotherapy for pancreatic cancer P-456 EACR25-0738 Valenzano Giampiero Poster Presenter United Kingdom Development of a humanized anti-ANXA3 monoclonal antibody for potential treatment of hepatocellular carcinoma P-457 EACR25-0752 IANTO BOSHENG HUANG Poster Presenter Hong Kong, China Tumor-infiltrating immune cell types predicting recurrence-free survival in melanoma patients receiving adjuvant PD-1 inhibitor therapy P-458 EACR25-0974 Andrea Lad Poster Presenter Hungary Novel Harnessing of Innate and Adaptive Anti-Cancer Immunity: NLRP3-Inflammasome Activation Facilitates Immune Checkpoint Blockade in the Treatment of Mesenchymal Stage IV Colorectal Cancer P-459 EACR25-1026 Klimpe Luis Poster Presenter Germany Immunopeptidomics approach for the identification of neoantigens in multiple myeloma P-460 EACR25-1028 Gabriela Anna Zuleger Poster Presenter Germany Bridging the Gap Between In Vitro and In Vivo: STC-1010 Cancer Vaccine Efficacy in 3D Tumor Spheroids P-461 EACR25-1044 George Alzeeb Poster Presenter France CAM Assay: An Alternative, 3Rs-compliant, In Vivo Model for the Development of Anticancer Immunotherapies P-462 EACR25-1120 Yan Wang Poster Presenter France Targeting UMG1, a highly glycosylated cancer specific CD43 epitope, by a Bispecific T-Cell Engager (BTCE) in Malignant Melanoma P-463 EACR25-1140 EMANUELA ALTOMARE Poster Presenter Italy Exploiting human ALK.CAR-T cell therapy for the treatment of ALK+ small cell lung cancer P-464 EACR25-1142 Monkca Maccagno Poster Presenter Italy Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy P-465 EACR25-1156 Tatiana Hurtado de Mendoza Poster Presenter United States Comparative analysis of neoadjuvant PD1+Lenvatinib versus PD1 alone in the tumour immune microenvironment of melanoma: Correlation of immune profiling with pathological response. P-466 EACR25-1196 Jordan William Conway Poster Presenter Australia Optimized Timing of CD25-Biased IL-2/JES6 (IL-2/IL-2 mAb Complex) Administration Enhances Antitumor Efficacy of Immune Checkpoint Inhibitors P-466A EACR25-1240 Irfan Baki K Poster Presenter Czech Republic CD25-Biased IL-2/Anti-IL-2 Complexes Enhance Antigen-Primed CD8⁺ T Cell Expansion, Overcome Treg-Mediated Suppression, and Exhibit Significant Antitumor Activity P-467 EACR25-1288 Petra Weberova Poster Presenter Czech Republic RALA-PRAME DNA Vaccine: A Novel Immunotherapy for High-Grade Serous Ovarian Carcinoma P-468 EACR25-1428 Chayanika Saha Poster Presenter United Kingdom Accelerating the Manufacture of γδ T Cells for Allogeneic Cancer Therapies: Integrated Cell Differentiation and Expansion in Bioreactors P-470 EACR25-1528 Miguel de Almeida Fuzeta Poster Presenter Portugal Blockade of PD-L1 endocytosis by uPAR antagonist peptides to improve cancer immunotherapy P-471 EACR25-1544 Elena Frediani Poster Presenter Italy Impact of Immune Checkpoint Inhibitors on Recurrence Patterns in Early-Stage NSCLC P-471A EACR25-1554 Sofia Silva Poster Presenter Spain Targeting solid tumor cell lines of diverse histological origins with nucleolin-specific CAR-T cells - a proof-of-concept P-472 EACR25-1684 Teresa Raquel Abreu Poster Presenter Portugal Immunization against a mutant p53-derived neoantigen by a personalized oncolytic adenovirus P-473 EACR25-1700 Fred Bunz Poster Presenter United States IL17A depletion remodels pancreatic tumor matrix and boosts ENO1 vaccine efficacy P-474 EACR25-1822 Giorgia Tiberi Poster Presenter Italy Generation of versatile tumor target cell lines using the SpyCatcher/SpyTag system P-475 EACR25-1904 Filipa Moraes Poster Presenter Portugal Development of a faster potency assay for evaluation of immune cell-mediated cytotoxicity in vitro P-484A EACR25-1960 Zhong Yu Poster Presenter CAPTN-3: A novel platform of conditionally activated T cell and NK cell engagers P-476 EACR25-1964 Hadas Reuveni Poster Presenter Israel Detecting changes in the tumour microenvironment and in CAR T infiltration following chemotherapeutic priming using intravital imaging P-477 EACR25-2022 Marija Dinevska Poster Presenter Australia Novel NK Cell Immunotherapy Strategy to Enhance Tumor Killing and Overcome Microenvironment Resistance P-478 EACR25-2174 Paola Vacca Poster Presenter Italy Neutrophil serine proteases alter IL-18 to a superkine P-479 EACR25-2188 Anne W Poster Presenter Sweden Unlocking the Potential of Dendritic Cell-Derived Extracellular Vesicles in Targeting Triple-Negative Breast Cancer P-915 EACR25-2224 Sofia Torres Quintas Poster Presenter Portugal Boosting Melanoma Immunotherapy: Synergizing Nanovaccines with PD-L1 Modulation P-480 EACR25-2430 Margarida Ferreira-Silva Poster Presenter Portugal Anti-CD19 therapy (Blinatumomab®) as a bridge therapy for hematopoietic stem cell transplantation in pediatric patients with relapsed/refractory B-type acute lymphoblastic leukemia Ph-negative P-481 EACR25-2510 Talita Fernandes Nunes Poster Presenter Brazil NK Cell Exhaustion in Multiple Myeloma: Pathways to Novel Immunotherapies P-482 EACR25-2554 Jacopo Umberto Verga Poster Presenter Ireland Accelerating immuno-oncology research with flexible workflows using modular Flex-Fit CyTOF panels P-483 EACR25-2558 Melissa Klug Poster Presenter RAS(ON) G12C-selective and multi-selective doublet combination overcomes clinical resistance mechanisms to KRAS G12C(OFF) inhibitors and sensitizes to immune checkpoint blockade in preclinical models P-484 EACR25-2588 Cristina Blaj Poster Presenter United States Poster and Exhibition Hall
10:45 20:00	MOLECULAR AND GENETIC EPIDEMIOLOGY Clinical Analysis of CNS WHO Grade 4 Gliomas with IDH-mutant versus IDH-wildtype Focused on CDKN2A Homozygous Deletion P-485 EACR25-0040 YOUNG ZOON KIM Poster Presenter Korea (Republic of) Enhanced antitumor immunity following neoadjuvant chemotherapy in triple-negative breast cancer P-486 EACR25-0060 Xun Zhong Xiong Poster Presenter China Facilitators and barriers of gastroscopy screening in high⁃risk populations for gastric cancer: a qualitative study P-487 EACR25-0062 Rong Yan Tan Poster Presenter China Bioinformatics analysis for the identification of key genes and microRNAs related to bone metastasis in prostate cancer P-488 EACR25-0064 Feng Yao Poster Presenter China Trends of prostate cancer stage and grade over a 12-year period in Northern Ireland; a population-based analysis P-489 EACR25-0198 Jack Murphy Poster Presenter United Kingdom Mapping Genetic Risk Variants for Sporadic Colorectal Cancer in a Brazilian Population: Insights from a Genome-Wide Association Study P-490 EACR25-1676 Rafaela Dias Oliveira Poster Presenter Portugal Chamosite in Late Permian C1 coal and the high incidence of lung cancer in Xuan Wei P-491 EACR25-1706 Renyue Ji Poster Presenter Hong Kong, China Effect of Pathogenic Mismatch Repair (MMR) Genes on the Systemic Metabolome and Their Link to Cancer Risk in a Lynch Syndrome Cohort P-492 EACR25-1726 Tiina Jokela Poster Presenter Finland Sociodemographic and clinicopathologic features associated with rapid relapse in triple-negative breast cancer: A Swedish nationwide registry-based study P-493 EACR25-1750 Toshima Z Parris Poster Presenter Sweden Exploring the role of monoallelic pathogenic MUTYH variants in colorectal cancer risk: Clinical implications and genetic findings in Serbian population P-494 EACR25-1850 Valentina Karadzic Poster Presenter Serbia Changing epidemiology and trends in incidence of childhood acute lymphoblastic leukaemia in Scotland: An analysis of the national cancer registration data, 1971-2020 P-495 EACR25-2528 Anjum Memon Poster Presenter United Kingdom Poster and Exhibition Hall
10:45 20:00	PREVENTION AND EARLY DETECTION Implementing cancer prevention strategies in the occupational setting: the Cancer Prevention at Work (CPW) study protocol P-496 EACR25-0066 Rick Kye Gan Poster Presenter Spain Characterize the spatial biology of HPV infection in tissue with multiplexing P-497 EACR25-0146 Morgan Mathieu Poster Presenter Switzerland Insights into Molecular and Immune Mechanism of Chemo Prevention of Aegle marmelos Fruit Extract: Preclinical and Preventive Strategies in Colitis Associated Colon Cancer Pathogenesis P-498 EACR25-0234 Nirmal Kumar Kasinathan Poster Presenter India Personalized Initial Screening Ages for Colorectal Cancer Based on Detailed Family History in Western Europe P-499 EACR25-0302 Teresa Seum Poster Presenter Germany Lifestyle intervention during colorectal cancer screening: a pilot study in France P-500 EACR25-0346 Aline Al Nahas Poster Presenter France Predictors of colorectal neoplasia among individuals with a family history of CRC aged 40 to 54 years: Objective Risk vs. Perceived Risk P-501 EACR25-0860 Julia Hibbert Poster Presenter Germany Participant-related risk factors for false positive faecal occult blood test results in screening for colorectal cancer – a systematic review and meta-analysis P-502 EACR25-0998 Winnie Roerbaek Poulsen Poster Presenter Denmark Effect of TiO2, as food additive E171 or nanoparticules, on colorectal carcinogenesis and colibactin-producing Escherichia coli virulence P-503 EACR25-1004 Charline Juban Poster Presenter France Investigating how Mitochondrial Dysfunction Promotes Breast Carcinogenesis in a Stiff Extracellular Matrix P-504 EACR25-1018 Fabianna Tennant Poster Presenter United Kingdom OUTLIVE-CRC “Improving prognosis and quality of life of young CRC patients: Tertiary prevention through multi-marker models and nutritional interventions” P-505 EACR25-1208 Stefanie Derer-Petersen Poster Presenter Germany Prevalence and Clinical Characteristics of High-Risk HPV in Women from Underserved and Remote Regions of Colombia P-506 EACR25-1690 Rafael Parra-Medina Poster Presenter Colombia Menarche, menopause, and female breast cancer risk in China and the UK: comparative findings from three large cohorts P-507 EACR25-1888 Xuan Li Poster Presenter United Kingdom Melanoma and health inequity in the UK P-508 EACR25-2300 Selina Robertson Poster Presenter United Kingdom The Impact of Emotional Intelligence on Mental Health: A Protective Factor in Breast Cancer Survivors P-509 EACR25-2514 Rocio Guil Poster Presenter Spain Broad-Spectrum Antiviral Activity of Ganoderma Microsporum Immunomodulatory Protein: Targeting Glycoprotein gB to Inhibit EBV and HSV-1 Infections via Viral Fusion Blockage P-509A EACR25-0312 Ngoc Kha Di Vo Poster Presenter Taiwan Poster and Exhibition Hall
10:45 20:00	RADIOBIOLOGY / RADIATION ONCOLOGY Evaluating the role of ATM inhibitors in enhancing the efficacy of radiotherapy and their potential to improve the immunosuppressive microenvironment of glioblastoma P-510 EACR25-0206 TSAI-LAN LIAO Poster Presenter Taiwan Advanced 3D glioblastoma models for investigating radiopharmaceutical therapy P-511 EACR25-0402 Catarina Isabel Guilherme Pinto Poster Presenter Portugal Ro 90-7501 Enhances The Radio-Sensitivity of Breast Cancer Cells by Impairing DNA Double-Strand Break Repair Mechanisms P-512 EACR25-0444 Charbel Joseph Feghaly Poster Presenter Lebanon Impact of Lamin Mutations on Radiation Response in Lung Cancer P-513 EACR25-0536 Janina Janetzko Poster Presenter Germany Radioresistance of colorectal cancer cells is driven by GPX4 and ferroptosis resistance. P-514 EACR25-0578 ROBIN JEHAY Poster Presenter Belgium Upconversion Nanoparticle-Mediated Neutron Capture Therapy Lu-177 Treatment in Head and Neck Squamous Cell Carcinoma via the c-MET Signaling Pathway P-516 EACR25-1098 Kai-Hung Lin Poster Presenter Taiwan Treatment of Orthotopic Human GBM Tumours in Mice Using Auger Electron-Emitting 197Hg-Gold Nanoparticles Administered by Convection-Enhanced Delivery P-517 EACR25-1158 Madeline Brown Poster Presenter Canada Radiosensitivity and DNA Damage Response in Human Sarcoma: p53-Dependent and Independent Mechanisms Under Alpha-Particle Radiation P-518 EACR25-1160 Ahmad Sheikh Poster Presenter Israel Combining Hypoxia and Stemness Biomarkers with Hematoxylin and Eosin Stained Images improves Radiosensitivity Classification in Head and Neck Cancer Preclinical Models P-519 EACR25-1300 Cylia Ouadah Poster Presenter Germany Novel biomarkers for Radiotherapy response in Small Cell Lung Cancer P-520 EACR25-1384 CATERINA DE ROSA Poster Presenter Italy Investigating the Synergistic Effects of HDAC and ABC Efflux Transporter Inhibitors in Radiation-Resistant Triple Negative Breast Cancer P-521 EACR25-1594 Anita Gokulram Prajapati Poster Presenter India Radiation-induced effects by external beam radiotherapy in triple-negative breast cancer cellular models with or without BRCA1/2 mutations P-515 EACR25-21350 Maria Filomena Botelho Poster Presenter Portugal Exploring Synergistic Effects of Ionizing Radiation and Asparaginase to Treat Solid Tumors P-522 EACR25-2136 Leonardo Lonati Poster Presenter Italy Assessement of the combination of iron oxide nanoparticles and erastin to radiosensitize head and neck cancer cells P-523 EACR25-2154 Dorianne Sant'Angelo Poster Presenter Belgium The alpha-emitter radium-223 modulates migration, invasion and angiogenesis in metastatic prostate cancer preclinical models P-524 EACR25-2166 Maria Filomena Botelho Poster Presenter Portugal Normal Human Epithelial-Fibroblast 3D Spheroid Cultures for Modeling Radiation-induced Lung Injury P-525 EACR25-2426 Lisa Marie Stasch Poster Presenter Germany Response of non-small lung cancer cells to irradiation with helium ions P-526 EACR25-2516 Vladana Petkovic Poster Presenter Serbia Revolutionizing Pancreatic Cancer Treatment: The Game-Changing Duo of Radiotherapy and PARP Inhibitors P-527 EACR25-2544 Maria Filomena Botelho Poster Presenter Portugal Poster and Exhibition Hall
10:45 20:00	SIGNALING PATHWAYS New insights into the effects of coffee extracts on colon cancer and healthy human cells P-528 EACR25-0078 Martina Šemeláková Poster Presenter Slovakia Elucidating receptor-mediated modulation of cannabidiol activity in prostate cancer P-529 EACR25-0370 Maria Prencipe Poster Presenter Ireland Role of intracrine VEGFA-VEGFR1 signaling in BRAF mutated melanoma P-530 EACR25-0404 Valery Sarlo Poster Presenter Italy Decipher the Roles of IL-6 Signaling in CTPS Filament-mediated Cancer Progression P-531 EACR25-0694 Chun Yen Wang Poster Presenter Taiwan SRF fusions act as hyperactivated transcription factors in pediatric tumors P-532 EACR25-0838 Constance Pirson Poster Presenter Belgium IL-6/STAT3 Regulates Solid Stress Enhanced Migration and Invasion in Breast Cancer Cells P-533 EACR25-0964 Ryna Shireen Sheriff Poster Presenter Singapore Uncovering the paraspeckle-dependent and independent role of NONO in transcriptional regulation in Multiple Myeloma P-534 EACR25-1066 Elisa Taiana Poster Presenter Italy A novel regulator of Hedgehog signaling and stemness in prostate cancer P-535 EACR25-1266 ChenKai Yen Poster Presenter Taiwan Elevated temperatures induce PDCD1 expression via HSF1 activation. P-536 EACR25-1276 Wies_awa Wid_ak Poster Presenter Poland Decoding EGFR-Driven Transcriptional Networks in NSCLC P-537 EACR25-1568 Daniel James Goodall Poster Presenter Netherlands Glucocorticoid signaling regulates luminal A and triple negative subtypes of breast cancer differently on the epithelial-mesenchymal transition pathway P-539 EACR25-1666 jun Ling Poster Presenter United States SP1 Downregulates ADAMTS-8 mRNA Expression in Colorectal Cancer Model P-540 EACR25-1864 Meltem ALPER Poster Presenter Turkey IL-6-upregulates MIR100HG gene expression in Hepatocellular Carcinoma P-538 EACR25-1896 Feray K Poster Presenter Turkey The effects of 17β-estradiol on the expression and functionality of large-conductance voltage- and Ca2+-activated potassium channels in human glioblastoma cells P-541 EACR25-2184 Klaudia Skutnik Poster Presenter Poland Unveiling the Molecular Mechanisms of KCa3.1 in Pancreatic Cancer Development P-542 EACR25-2200 Veronica Carpanese Poster Presenter Italy Regulation of MBD4 expression and cell-cycle mediated Interactions with the DNA Mismatch Repair (MMR) pathway P-543 EACR25-2232 Amanda Kahn Poster Presenter France Coordinated Changes in Midkine Expression and Its Receptor Network in Gliomas P-544 EACR25-2432 Radoslaw Zagozdzon Poster Presenter Poland Utilising interactomics to map the role of the pancreatic tumour microenvironment in rewiring mutant KRAS signaling P-910 EACR25-2442 Nasir Abbas Haider Poster Presenter United Kingdom Receptor tyrosine kinases as suitable molecular targets in the precision treatment of giant cell tumor of bone P-545 EACR25-2602 Jakub Neradil Poster Presenter Czech Republic Poster and Exhibition Hall
10:45 20:00	TRANSLATIONAL RESEARCH Natural stilbenes in prostate cancer targeted interception and therapy: pre-clinical studies P-546 EACR25-0074 Anait S Levenson Poster Presenter United States Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer P-547 EACR25-0108 Luba Hun Poster Presenter Slovakia A Tumour Organoid Biobank for Mapping Cancer Cell Vulnerabilities P-914 EACR25-0328 GABRIELE PICCO Poster Presenter United Kingdom Treatment response and survival of patients with early-onset compared to older-onset colorectal cancer in the Netherlands P-548 EACR25-0342 Lauri Borghuis Poster Presenter Netherlands SWOT Analysis for Maintaining the Sustainability of Newly Established Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia P-549 EACR25-0416 Snezana Bjelogrlic Poster Presenter Serbia Breast cancer immunotherapy using magnetised oncolytic virus P-550 EACR25-0500 Munitta Muthana Poster Presenter United Kingdom In vitro strategy to discover therapeutic targets in PDAC P-551 EACR25-0524 Julie Le Naour Poster Presenter France Protein Tyrosine Phosphatase Receptor type Psi (PTPRU) in clinical breast cancer P-552 EACR25-0526 Zhonghang Xu Poster Presenter United Kingdom Ovarian cancer Zebrafish Avatars for personalized multiple drug testing P-553 EACR25-0644 Marta Estrada Poster Presenter Portugal Malignant Ascites Derived Organoids from Ovarian Cancer Patients for Understanding Platinum Resistance and Approaching Targeted Therapy P-554 EACR25-0654 Melek Denizli Poster Presenter Spain BQ323636.1 Overexpression Drives mTOR Signaling and Lipid Metabolism via ACSL4 in ER-positive Breast Cancer P-555 EACR25-0688 Ui Soon Khoo Poster Presenter Hong Kong, China Trametinib for NRAS-mutated tumors: Results from the Drug Rediscovery Protocol (DRUP) P-556 EACR25-0778 Florentine Verbeek Poster Presenter Netherlands Investigating the Therapeutic and Prognostic Utility of Long Non-Coding RNA Targets and their Association with Tumour Microenvironment in KRAS-Mutant NSCLC P-557 EACR25-0798 Clodagh Murphy Poster Presenter Ireland Canine Melanoma as a Translational Model for Novel Immuno-Nanotherapy and Focal Adhesion Kinase-targeted Strategies in Human Oncology P-558 EACR25-0890 Marta Silva Poster Presenter Portugal Detection of low frequency variants from low input FFPE samples with comprehensive tumor/normal exome sequencing P-559 EACR25-0916 Anna Babayan Poster Presenter Germany M2 macrophages promote survival and proliferation of patient-derived gastric cancer organoids in a tumor biology-dependent manner P-560 EACR25-0968 Manuel Cabeza-Segura Poster Presenter Spain Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes P-561 EACR25-0976 Anniina F Poster Presenter Finland Exosomes from urine: A multi-purpose system for urine liquid biopsy P-562 EACR25-1014 SERENA BONIN Poster Presenter Italy PET imaging of PD1-positive MOLT-4 T-cell lymphoblastic leukemia tumours in NRG mice using 89Zr-labeled pembrolizumab P-563 EACR25-1130 Stephanie Borlase Poster Presenter Canada Beating Breast Cancer Brain Metastases: Leverage Nano-Immunotherapy to Re-educate Host Immunity P-564 EACR25-1180 Ana I Matos Poster Presenter Portugal PET-based and glycolytic biomarkers reveal 18F-FDG uptake/heterogeneity phenotypes and predict metabolically active disease in aggressive B-cell lymphomas P-565 EACR25-1190 Farid Cury Neto Poster Presenter Brazil Engineered v5 PE6A-VLPs Enable In Vivo PCSK9 Gene Editing to Suppress Hepatocellular Carcinoma Progression and Modulate Cholesterol Metabolism P-566 EACR25-1192 LIBIN DENG Poster Presenter Hong Kong, China Whole exome sequencing of non-small cell lung cancers in a cohort of patients enriched for genetic tumor risk P-567 EACR25-1456 Júlia Wiggeshoff Poster Presenter Germany Improving intraoperative tumor margin assessment in lung cancer surgeries using the MasSpec Pen technology P-568 EACR25-1704 Yasmin Shanneik Poster Presenter United States Enhancing Anti-Tumor Activity in Pancreatic Cancer by Targeting PI3Kδ and Autotaxin P-569 EACR25-1770 Maciej Garczyk Poster Presenter Switzerland Loss of the tumor suppressor NUMB drives aggressive bladder cancer via hyperactivation of the RHOA-ROCK-YAP pathway: implications for personalized prognosis and targeted therapy P-570 EACR25-1786 SALVATORE PECE Poster Presenter Italy Innovative Multiomic Spatial Biology Assay for Comprehensive Immune Profiling of the Tumor Microenvironment P-571 EACR25-1934 Jannik Boog Poster Presenter Germany Artificial intelligence predicts prognostic features of patient survival related to microvascular invasion and molecular classes of hepatocellular carcinoma P-572 EACR25-1966 Agavni Mesropian Poster Presenter Spain Preclinical combination of selenium nanoparticles and a nanovaccine demonstrates immunotherapeutic properties against luminal B breast cancer P-573 EACR25-2002 Cl Poster Presenter Portugal Hyaluronic Acid-Coated Nanoparticles for Targeted Delivery in Colorectal Cancer: Unlocking the Potential of CD44-Dependent Therapy P-574 EACR25-2012 Rebecca Amico Poster Presenter Italy Building precision oncology via real-world data standardization, privacy preserving infrastructures, and collaboration among IT and clinical experts: TheDIGICORE network experience P-575 EACR25-2016 ALBERTO TRAVERSO Poster Presenter Italy 3D printing in microfluidic device prototyping for cancer research P-576 EACR25-2048 Dominik Thomas Bereta Poster Presenter Poland Characterisation of the Colon Adenocarcinoma microenvironment with a focus on Natural Killer Cells P-577 EACR25-2094 Mafalda Jacob Poster Presenter Portugal Tissue-Engineered Human 3D Tumor Models for Predictive Preclinical Anti-Cancer Therapy Assessment P-578 EACR25-2104 Maximiliane Wussmann Poster Presenter Germany Organotypic Slice Cultures as a Feasible Predictive Model for Carboplatin Response in High-Grade Serous Ovarian Cancer (TOSCA Study) P-579 EACR25-2156 Sonia Mastrogiovanni Poster Presenter Italy Advanced Biomonitoring System for Colorectal Cancer Survivors: Enhancing Early Detection and Continuous Monitoring of Anastomotic Dehiscence P-580 EACR25-2178 Maria Filomena Botelho Poster Presenter Portugal Cancer cell therapy using gold-doped carbon dots for biorthogonal catalysis P-581 EACR25-2352 Mafalda Laranjo Poster Presenter Portugal Establishing Robust In Vitro and In Vivo Models of Mesothelioma for Enhanced Translational Research P-582 EACR25-2398 Filipe Duarte Azevedo Poster Presenter Portugal Cytotoxicity of novel multifunctional carbon nanocapsules P-583 EACR25-2402 Mafalda Laranjo Poster Presenter Portugal A systematic review of Cancer spontaneous remission (CSR) and post-radiation abscopal responses (p-rAR) P-584 EACR25-2404 Tim Oliver Poster Presenter United Kingdom A deep-learning approach for tissue mapping and cell phenotyping in imaging mass cytometry data analysis P-585 EACR25-2570 Melissa Klug Poster Presenter The Role of SLCO1B1 and SLCO1B3 Transporters in Breast Cancer Imaging. P-585A EACR25-08910 Louise Robyn Page Poster Presenter United Kingdom Poster and Exhibition Hall
10:45 20:00	TUMOUR BIOLOGY Heterogenous tumor immune microenvironment in mismatch repair deficient colorectal cancer patients receiving immune checkpoint inhibitor P-586 EACR25-0012 Wonsuk Lee Poster Presenter Korea (Republic of) The Effects of Palmitic Acid and Insulin as Diabetic Stress Markers in Breast Cancer Associated Fibroblast Model in vitro P-587 EACR25-0020 Wisam Nabeel Ibrahim Al-IEDANI Poster Presenter Qatar Tumor budding cells express Trop-2 as a driver of colon cancer cell migration and invasion P-588 EACR25-0036 Saverio Alberti Poster Presenter Italy Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia P-589 EACR25-0058 HONG-CHEN CHEN Poster Presenter Taiwan The prostate specific SOCS1-deficient mouse model to study the gut-prostate axis in the pathogenesis of prostate cancer P-590 EACR25-0120 Mozhdeh Namvarpour Poster Presenter Canada LncRNA PRKCQ-AS1 promotes cancer cell proliferation and inhibits etoposide-induced apoptosis via modulation of HOX5A. P-591 EACR25-0140 Doron Ginsberg Poster Presenter Israel Erythrocyte-derived sphingosine-1-phosphate promotes tumor cell survival in the circulation P-592 EACR25-0162 Adriana Vucetic Poster Presenter Germany Deciphering the Role of TCF21 in Regulating the Cancer-Associated Fibroblast (CAF) State in High Grade Serous Ovarian Cancer P-593 EACR25-0166 Ngoc Bui Poster Presenter Canada Defining the metastatic niche for colorectal cancer dissemination P-594 EACR25-0184 Mahsa Mohammadi Poster Presenter United Kingdom Transcriptomics analysis identifies intronic RNAs in ER+/PR+ and HER2-enriched ductal breast carcinoma P-595 EACR25-0226 Nazl Poster Presenter Turkey Patterns of Bone Marrow Adipogenesis in Response to Chemotherapy P-596 EACR25-0266 Lauren Kreps Poster Presenter Canada Reprogramming the immunosuppressive tumor microenvironment to overcome resistance to CAR T-cell immunotherapy in pancreatic cancer P-597 EACR25-0272 Serena Tondi Poster Presenter Italy The role of the neuronal-cancer crosstalk in melanoma brain metastases using hPSC-derived Assembloids P-598 EACR25-0280 Antonietta Verrillo Poster Presenter Italy Immunomodulation of Glioblastoma Tumor Microenvironment by NF1-LRD-Loaded Extracellular Vesicles P-599 EACR25-0290 IVY HO Poster Presenter Singapore Combined K8 and Apc loss-derived mouse model for colon-specific tumorigenesis P-600 EACR25-0300 Mina Tayyab Poster Presenter Finland Impact of MAG-EPA supplementation on the prostate tumor immune microenvironment P-601 EACR25-0310 Lucie Leclair Poster Presenter Canada Local and systemic interactions drive prostatic intraductal carcinoma dissemination. P-602 EACR25-0358 Darya Yanushko Poster Presenter France Colorectal cancer hepatic metastasis modelling by advanced 3D bioprinting and demonstration of oncolytic viral chemotherapeutic delivery. P-603 EACR25-0378 Cl Poster Presenter France Three-dimensional Microtissues: An In-Vitro Platform to Recapitulate the Heterogeneity and Complexity of Head and Neck Squamous Cell Carcinoma P-604 EACR25-0398 Aanchal Chopra Poster Presenter Poland Tissue-specific fibroblast lipids drive epithelial cancer invasion P-605 EACR25-0406 Timothy Budden Poster Presenter United Kingdom MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer- associated fibroblasts P-606 EACR25-0446 Chlo Poster Presenter France Reprogramming of cancer-associated fibroblasts during the stepwise progression of colorectal cancer P-607 EACR25-0458 Myriam S Poster Presenter Finland Elucidating the molecular mechanisms involved in pancreatic cancer and liver microenvironment crosstalk facilitating liver metastasis P-608 EACR25-0486 Yair Roth Poster Presenter Israel A novel approach for the analysis of spatial cell distributions in the tumor microenvironment to predict bevacizumab response P-609 EACR25-0488 Jan-Lukas F Poster Presenter Norway The role of the Hippo signaling pathway in gastric cancer initiation and progression P-610 EACR25-0596 Therese Seidlitz Poster Presenter Germany Neoadjuvant chemotherapy modulates the tumor immune microenvironment in ovarian cancer based on homologous recombination status P-695 EACR25-0602 Juan A Marín-Jiménez Poster Presenter Spain Characterization of Dormant Persistor Origins Using Longitudinal Live Imaging P-611 EACR25-0616 Gemma Crupi Poster Presenter United Kingdom Dysadherin-mediated CA9 expression shapes an acidic tumor microenvironment to accelerate colorectal cancer aggression P-612 EACR25-0620 Jeong-Seok Nam Poster Presenter Korea (Republic of) A novel TROP2 complex affects colon cancer mechanobiology by modulating the cytoskeleton architecture P-613 EACR25-0624 Kerstin Huebner Poster Presenter Germany Understanding the genetic heterogeneity within clonal spheroids and its interaction with the tumor microenvironment P-614 EACR25-0634 ANSHU YADAV Poster Presenter India MLK4 role in the cross-talk between triple-negative breast cancer cells and tumour-associated macrophages. P-615 EACR25-0650 Alicja Mazan-Bury Poster Presenter Poland Secretomes of IFN-γ-Activated Colon Endothelial Cells Suppress Colorectal Cancer: Molecular Insights and Cell-Biological Effects P-616 EACR25-0658 Yanmin Lyu Poster Presenter Germany FOXM1 as a Key Regulator of Brain Metastasis Breast Cancer P-683 EACR25-0676 Shannon Cartay Kalsi Poster Presenter Ireland Exploring small nucleolar RNAs as predictors of radiotherapy outcome in breast cancer P-618 EACR25-0786 Emmi K Poster Presenter Finland The impact of CFTR impairment on endothelial cell and its role during tumor progression P-619 EACR25-0824 Lucas TREPS Poster Presenter France Emerging Subtypes in Ovarian High Grade Serous Carcinoma: Decoding Genomic and Functional Landscapes P-620 EACR25-0842 Giulia Micoli Poster Presenter Finland Establishing the Immune-Profile of Cholangiocarcinoma and the Utility of Human Precision-Cut Tumour Slices (hPCTS) as a Platform to Assess Immunotherapy Response P-621 EACR25-0862 Owen McGreevy Poster Presenter United Kingdom Secreted luciferases: a scalable, accessible, and 3R-compliant tool for longitudinal monitoring of autochthonous tumor growth in vivo P-622 EACR25-0878 Nastasja Merle Poster Presenter Germany Understanding the Role of Leukemia Inhibitory Factor (LIF) in the Bone Metastatic Microenvironment P-623 EACR25-0892 Cayetano Galera Poster Presenter Spain Monocyte/macrophage crosstalk with colorectal cancer in co-cultures - in vitro studies P-624 EACR25-0912 Paulina Pieni_dz-Feculak Poster Presenter Poland Cellular enlargement causes mitotic errors and aneuploidy in cells that evade senescence following chemotherapy P-625 EACR25-0924 Aanchal Udaynath Pareri Poster Presenter United Kingdom Characterization of hPBMC-ASID and hPBMC-ASIDβ2m−/− models for Immune-Oncology Studies P-626 EACR25-0926 YU-MIN LIN Poster Presenter Taiwan Unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers. P-627 EACR25-0928 Angela L Ferguson Poster Presenter Australia Cholesterol Transfer from PI-Activated TREM2+ Macrophages to Tregs Drives Lymph Node Immunosuppressive Pre-Metastatic Niche P-628 EACR25-0932 CUICUI HUANG Poster Presenter Hong Kong, China Translational Value of Hepatic Dnaja3-deficient Mice in Preclinical Testing of Novel HCC Therapeutics P-629 EACR25-0940 Teo Wan Huai Poster Presenter Taiwan Autophagy activation in response to cigarette smoke: Exploring the disparity in laryngeal cancer incidence and outcomes between sexes in South Korea P-630 EACR25-0948 Ah Ra Jung Poster Presenter Korea (Republic of) Reprogrammed fibroblasts promote melanoma progression and immune evasion in the lymph node niche P-631 EACR25-0954 M Poster Presenter France The NRG1/ERBB axis as a potential target to prevent targeted cancer therapy resistance P-632 EACR25-0966 Sara Sofia Peltola Poster Presenter Finland Characterizing Neuron-Neuroblastoma circuit development and its role in tumor progression P-633 EACR25-1024 Barbara Yael Braz Poster Presenter France Comprehensive screening of A-to-I editing in colorectal cancer: implications for tumour progression and therapeutic targeting. P-634 EACR25-1034 Magdalena Niemira Poster Presenter Poland The Role of Hypoxia-Inducible Factor-1α in shaping Cancer-Associated Fibroblast phenotypes in colorectal cancer P-635 EACR25-1036 Monica Gabola Poster Presenter Luxembourg Large-scale integrative analysis of fecal samples sequencing data from healthy and CRC patients supports novel miRNA-mediated host-microbiota interactions P-636 EACR25-1062 Alessandro Camandona Poster Presenter Italy Identifying Metastatic Drivers and Biomarkers in Colorectal Cancer – the zAvatar model as a surrogate for patient metastatic potential P-637 EACR25-1068 Bruna Costa Poster Presenter Portugal miR-27a Targets the Circadian clock circuitry to Drive Lung Adenocarcinoma Progression P-638 EACR25-1090 Emanuele Murgo Poster Presenter Italy Developing Comprehensive In Vitro and In Vivo Models: Patient-Derived Organoids (PDOs) and Xenografts (PDXs) for Morphological and Functional Analysis and Drug Screening in Head and Neck Squamous Cell P-639 EACR25-1094 Donatella Romaniello Poster Presenter Italy Peritoneum specific fibroblasts that can arise in response to various local disorders promote colorectal cancer peritoneal metastasis P-640 EACR25-1106 Cristiano Ramos Poster Presenter Austria N106S mutation in eIF6 may prevent tumour onset caused by mRNA translation defects in Shwachman-Diamond Syndrome P-641 EACR25-1134 Giacomo D'Andrea Poster Presenter Italy Identify the efficacy and mechanism of engineering UMSC/miR-145-5p-TRAIL and its derived exosome on hepatocellular carcinoma P-642 EACR25-1182 Chang Po-Lung Poster Presenter Taiwan The DNA repair factor NEI-like DNA glycosylase 3 activates tumor-associated macrophage polarization through regulating genomic stability in HCC P-643 EACR25-1188 Wenya Huang Poster Presenter Taiwan Spatial Metabolic Mapping of Metastatic Melanoma in Immunotherapy-Treated Patients P-907 EACR25-1198 Tuba Nur Gide Poster Presenter Australia Characterization of cysteine peptidase interplay between different cell populations in tumour microenvironment P-644 EACR25-1226 Marjeta Lipu_i_ Poster Presenter Slovenia The effects of selected piRNAs on ovarian cancer stem-like cells through piRNA mimic transfection P-645 EACR25-1258 Tuba Gunel Poster Presenter Turkey A single-cell atlas of the clear-cell renal cell carcinoma (ccRCC) tumor microenvironment (TME) identifies an interferon-responsive malignant cell subpopulation associated with lymphocyte-enriched TME P-646 EACR25-1272 Samuel Garc Poster Presenter Spain Rab27a deficiency fuels pancreatic tumor growth via a pro-inflammatory, immune-promoting tumor microenvironment P-647 EACR25-1286 Carolina Dias Poster Presenter Portugal Apoptosis-induced compensatory proliferation: optimization of colorectal cancer mouse model and establishment of mouse-derived organoids P-648 EACR25-1292 Ekatarina Mihajlovi_ Poster Presenter Serbia Prognostic and Molecular Features Associated with Tumour Border Properties in Colorectal Cancer P-649 EACR25-1296 Akseli Lennart Kehusmaa Poster Presenter Finland The role of periostin in the adhesion of pancreatic cancer cells P-650 EACR25-1370 Caitlin Alder Poster Presenter United Kingdom Perilipin 2 in Adipocytes of Omental Tumor Microenvironment Promotes Ovarian Cancer Cell Survival and Metastasis Through CXCL12/CXCR4 Axis P-651 EACR25-1372 Mingxia Xu Poster Presenter China Analysis of immunoglobulin producing tumour cells in colorectal cancer utilising highplex immunohistochemistry techniques P-652 EACR25-1394 Christina Enright Poster Presenter Ireland Reactivation of miR-29 Mitigates Epigenetic Deregulation and Tumor Progression in Advanced Prostate Cancer P-653 EACR25-1402 Arianna Vallerga Poster Presenter Italy Development of novel RNA aptamers for precision targeting of cancer-associated fibroblasts in NSCLC P-654 EACR25-1410 Giuseppe Ciccone Poster Presenter Italy TGFβ signaling in cancer-associated fibroblasts creates a pro-metastatic niche in colorectal cancer P-655 EACR25-1462 Subinuer Abudukelimu Poster Presenter Netherlands Molecular characterization of long non-coding RNA MINCR isoforms and their impact on prostate cancer progression P-656 EACR25-1492 Ilaria Cassotti Poster Presenter Italy The role of RNA Modifiers in Prostate Cancer Bone Metastasis: Insights from m6A RNA Methylation P-657 EACR25-1498 Klaudia Faustyna Detkiewicz Poster Presenter Sweden A Multiomics Imaging Approach to Characterize lncRNA-Protein Dynamics in Colorectal Cancer Progression P-658 EACR25-1508 Lisa Nechyporenko Poster Presenter Switzerland Stromal-immune interactions shape the bone metastatic niche P-659 EACR25-1526 Marva Langer Poster Presenter Israel The role of complement in pancreatic cancer: from complement activation and effector mechanism/s to combination with therapy P-660 EACR25-1576 Monica Dambra Poster Presenter Italy Exploring the Interactions within the Tumor Microenvironment of pancreatic neuroendocrine tumors (P-NETs) P-661 EACR25-1582 Alessandro Marangelo Poster Presenter Germany Oncofetal-chondroitin sulfate, key to tumor immune surveillance? P-662 EACR25-1602 Anne Martin Salazar Poster Presenter Denmark XPO6-Mediated Immune Evasion Limits TCR-T Efficacy in Nasopharyngeal Carcinoma P-663 EACR25-1618 Ziyang QI Poster Presenter China Role of DDR1 in tumoral progression through matrix extracellular remodeling and discovery of a novel partner of DDR1 in colorectal cancer (CRC) P-664 EACR25-1652 Mathilde ROUMIEUX Poster Presenter France miR-30d inhibition activates the cGAS/STING/IFN-I pathway stimulating an innate immune response via LATS2/YAP axis in breast cancer P-665 EACR25-1658 Suvarna Chatterjee Poster Presenter India Characterization of extracellular vesicles derived from cancer-associated fibroblasts in oral squamous cell carcinoma P-666 EACR25-1688 Iasmin Nogueira Bastos Poster Presenter Brazil Repurposing Tricyclic Antidepressants for Glioblastoma Treatment P-667 EACR25-1784 Eleni Lamprou Poster Presenter Switzerland Metastatic peritoneal fibroblasts mobilize and respond to TGF-β1 from the extracellular matrix of colorectal cancer P-668 EACR25-1792 Cristiano Ramos Poster Presenter Austria Tumor Heterogeneity and Immune Modulation in Oesophageal Squamous Cell Carcinoma Characterised by Single-Cell RNA Sequencing Analysis P-669 EACR25-1798 Wing Yan Carissa Wong Poster Presenter Hong Kong, China Multiomic profiling of colon cancer sidedness reveals TGFβ-driven EMT and Mast cell dynamics as key prognostic factors P-670 EACR25-1812 Blanca Garc Poster Presenter Spain Oxidative stress promotes Colorectal cancer aggressiveness through transmembrane Chloride Intracellular Channel 1 (tmCLIC1) antioxidant activity P-671 EACR25-1816 Francesca Cianci Poster Presenter Italy Thrombospondin-1, RANK and OPG interactions in breast cancer osteolytic bone metastasis P-672 EACR25-1826 Giulia Taraboletti Poster Presenter Italy Mouse intraductal model of ER+ breast cancer to study the role of HSF1 in its development. P-673 EACR25-1856 Natalia Vydra Poster Presenter Poland Extracellular Matrix-Based 3D Head and Neck Cancer Model: A Biofabricated Platform for Testing Melatonin Therapy P-674 EACR25-1868 Juan Antonio Marchal Poster Presenter Spain Cellular and molecular features of the aberrant vascularization and mechanisms of TKI resistance in metastatic clear cell renal cell carcinoma P-675 EACR25-1876 Camille L Poster Presenter France miR-31-3p inhibition as strategy to increase responsiveness to trastuzumab in HER2 positive breast cancer P-676 EACR25-1886 Giulia Cosentino Poster Presenter Italy Adaptation to chromosomal instability in colorectal cancer creates vulnerabilities in epigenetic and growth regulators P-677 EACR25-1910 Alessandro D'Ambrosio Poster Presenter Italy Harnessing Mechano-Modulation: Enhancing Nano-Immunotherapy Efficacy by Targeting the Tumor Microenvironment in Sarcomas and TNBC P-678 EACR25-1914 Constantina Neophytou Poster Presenter Cyprus Tunable Biomimetic Hydrogels to Reproduce the Breast Tumor Microenvironment for Advanced 3D Cancer Modeling P-679 EACR25-1928 Giovanni Lo Bello Poster Presenter Italy Mapping of human prostate tumour heterogeneity using AtlasPlex immunofluorescence approach P-680 EACR25-1968 Eugenia Kuteeva Poster Presenter Sweden A Novel Transgenic Mouse Model to Assess On-Target Off-Tumor Toxicities of HER2-Targeted Therapies P-681 EACR25-1976 Santiago Duro-Sanchez Poster Presenter Spain ADAR1-Mediated RNA Editing as an Oncogenic Driver in Prostate Cancer P-682 EACR25-1998 Stefania Kalogera Poster Presenter Sweden Functional role of unannotated small RNA cluster 1 (smRC1) during hepatocarcinogenesis and angiogenesis P-684 EACR25-2068 Francesca Pagani Poster Presenter Germany Bidirectional interaction between Schwann cells and cancer cells of Hepatocellular carcinoma: implications for tumor progression. P-685 EACR25-2070 elisa Pizzichini Poster Presenter Italy Neurosurgery in glioblastoma induces proneural-to-mesenchymal transition, therapy resistance and immunosuppression by ischemic hypoxia P-686 EACR25-2074 Giorgio Seano Poster Presenter Development of a microphysiological system reflecting breast cancer lymph node metastasis P-687 EACR25-2078 Li Sha Poster Presenter Ireland miR-574-5p is a regulator of ARV7 expression in a potential allele-specific manner P-688 EACR25-2080 Jasper Van Goubergen Poster Presenter Belgium xRNA in Ovo: Target Validation and Efficacy Studies Using Chicken Embryo Model (CAM Assay) P-689 EACR25-2152 Yan Wang Poster Presenter France Spatial profiling of the colonic immune microenvironment reveals modulation by intestinal estrogen receptor beta and sex P-690 EACR25-2176 Lina Stepanauskaite-Bellisario Poster Presenter Sweden A Vascularized Tumor-on-Chip Model for Patient-Relevant Drug Screening in Non-Small Cell Lung Cancer P-691 EACR25-2182 Soheila Zeinali Poster Presenter Switzerland Targeting tumor hypoxia and immune blockade to improve breast cancer therapy P-692 EACR25-2214 Laura Svajda Poster Presenter Hungary Dissecting the role of retinoic acid signaling in human chronic lymphocytic leukemia using novel 3D lymph node-like microenvironments P-693 EACR25-2228 Martina Franchino Poster Presenter Italy Deciphering the involvement of cancer associated fibroblasts on the aberrant vasculature in clear cell renal cell carcinoma and the resistance to targeted treatments P-694 EACR25-2244 Victoire Poster Presenter France Decoding Sarcoma Complexity: Harnessing Xenopus tropicalis for In Vivo Studies of Liposarcoma, Desmoid Tumors, and Beyond P-696 EACR25-2272 Marthe Boelens Poster Presenter Belgium ETV6::JAK2 fusion promotes central nervous system invasion in murine B-cell acute lymphoblastic leukemia P-697 EACR25-2274 Telma Costa Poster Presenter Portugal Development of new in vitro organotypic cultures for the evaluation of anti-tumor drug sensitivity P-698 EACR25-2292 Andrea Vincenzo Cavallaro Poster Presenter Italy Impact of Brain-Derived Neurotrophic Factor (BDNF) on Tight Junction (TJ) Proteins and Cell Adhesion and Migration in Breast Cancer: Implications for Brain Metastasis P-699 EACR25-2296 Milad Mahmoud Milad Eshmela Poster Presenter United Kingdom Exploring GAS5 lncRNA impact in precision prognostics and bortezomib response in multiple myeloma P-167 EACR25-2320 Margaritis Avgeris Poster Presenter Greece Single-cell transcriptomics identifies vulnerabilities of osimertinib ex-vivo persister cells P-700 EACR25-2332 Fernando Calero Nieto Poster Presenter United Kingdom A uveal melanoma murine model which faithfully recapitulates organotropism and dormancy P-701 EACR25-2346 Larissa Viviana Isenegger Poster Presenter United States Genetic deconstruction of prostate cancer heterogeneity through a unique preclinical mouse modelling platform (ProMPt) P-702 EACR25-2356 Nicole Pandell Poster Presenter United Kingdom Engineered 3D osteosarcoma microenvironment model: Bridging in vitro - in vivo gap in cancer research and anticancer drug screening P-703 EACR25-2378 Jasmina Stojkovska Poster Presenter Serbia Extracellular Vesicles from Melanoma-Associated Fibroblasts Promote Pro-Tumourigenic Changes in Brain Endothelial Cells P-704 EACR25-2406 James Robert Boyne Poster Presenter United Kingdom Androgen Receptor Loss Drives Nuclear Instability in Cancer-Associated Fibroblasts: A Novel Mechanism of Tumor-Stroma Remodeling P-705 EACR25-2438 Soumitra Ghosh Poster Presenter India Targeting RNA splicing as a novel therapeutic strategy in ovarian high-grade serous carcinoma P-706 EACR25-2454 Anke Nijhuis Poster Presenter United Kingdom ADAMTSL1 orchestrates cell state dynamics in muscle regeneration and rhabdomyosarcoma P-707 EACR25-2464 Cl Poster Presenter France m6A epitranscriptome landscape in bladder tumors: translational impact in patients’ prognosis and treatment outcome P-708 EACR25-2472 Margaritis Avgeris Poster Presenter Greece miR-214 Modulates Pigmentation and Therapy Resistance in Cutaneous Melanoma P-709 EACR25-2484 Elena Andreucci Poster Presenter Italy Simple and cost-effective cancer diagnosis in liquid biopsy through native tRNA sequencing P-710 EACR25-2492 Oguzhan Begik Poster Presenter Spain CD44v6-Targeted CAR-T Immunotherapy to reduce metastatic evolution in Thyroid Cancer P-711 EACR25-2498 Roberta Drago Poster Presenter Italy Transcriptomic profiling of immune gene signatures in invasive breast carcinoma P-911 EACR25-2500 Nanfizat Abiket Alamukii Poster Presenter Sweden IMPACT OF PREOPERATIVE TREATMENT ON THE TUMOR MICROENVIRONMENT OF LIVER METASTASES FROM COLORECTAL CANCER P-712 EACR25-2508 Natalia Molina Poster Presenter Spain 3D Cell-derived ECM Production for Humanized Lung Cancer in vitro Model Development P-713 EACR25-2524 Luis Ferreira Poster Presenter Pancreatic Ductal Adenocarcinoma on Chip for Therapy Screening P-714 EACR25-2532 Mariana Santos Bento Poster Presenter Portugal Standardization of a Murine Model of Colorectal Cancer Induced by AOM/DSS and Evaluation of the Chemopreventive Capacity of the 5-Fluorouracil-Curcumin Hybrid P-715 EACR25-2534 Elizabeth Correa Gomez Poster Presenter Colombia Biogenesis of miR-155 under oxidative stress in lymphoma cells P-716 EACR25-2542 Weronika Sokolowska Poster Presenter Poland Extracellular matrix profiling reveals human colon cancer-specific features related to tumor sidedness P-717 EACR25-2560 Maria J Oliveira Poster Presenter Portugal circRNAs-miRNAs-mRNAs regulatory axis of genes associated with hereditary prostate cancer: in silico analyses for screening potential biomarkers P-718 EACR25-2580 Igor Araujo Vieira Poster Presenter Brazil Drugable oncofetal RBP Musashi-1 provides a novel Approach for Therapy in immunologically cold High-grade Serous Ovarian Cancer Tumors P-719 EACR25-2582 Robin Benedikt Rolnik Poster Presenter Germany Cellular Model of Giant Cell Tumor of Bone: Insights from In Vitro and In Vivo Studies P-720 EACR25-2600 Petr Chlapek Poster Presenter Czech Republic Androgen and ATF4 Pathways Regulate APOBEC3B-induced DNA Damage in Prostate Cancer P-720A EACR25-22130 Ahmed Ali S Alkhateeb Poster Presenter United Kingdom Poster and Exhibition Hall
10:45 20:00	TUMOUR EVOLUTION AND HETEROGENEITY Unveiling the heterogeneity of pancreatic cancer initiation: a novel perspective on normal-mutant cell-cell Interactions P-721 EACR25-0646 Ella Reed Poster Presenter United Kingdom Integrative analysis of tumor progression, phylogeny and timing with long-read mutational and methylation data P-909 EACR25-0686 Nataliya Guteneva Poster Presenter Russia Development of an innovative microdissection platform to study tumor spatial heterogeneity P-722 EACR25-0784 Maxime Golias Poster Presenter France Barcode-based lineage tracing to track breast cancer clonal evolution P-723 EACR25-0834 Candice Merle Poster Presenter France Unraveling Breast Cancer Heterogeneity: Microfluidic Sorting and Bioassay-Based Functional Analysis P-724 EACR25-1256 Esra Yilmaz Poster Presenter Sweden Investigating Clonal Dynamics and Drivers of Oxaliplatin Resistance in Colorectal Cancer Using Cellular Barcoding Technology in SW480 Cell Line P-725 EACR25-1414 Oyku Yagmur Basar Poster Presenter Turkey Homopolymer diversity at ultrafast evolving loci accurately reflects tumour mutation rate in mismatch repair-deficient (MMRd) CRC P-726 EACR25-1510 Lauren Eve McKenzie Poster Presenter United Kingdom Exploring the role of intratumor heterogeneity and tumor microenvironment crosstalk in the acquisition of cisplatin resistance in High-Grade Ovarian Carcinoma models P-727 EACR25-1606 Ludovica Perotti Poster Presenter Italy Selective Inter-clonal Interaction is Crucial for the Metastatic Phenotype of BRAF-inhibitor Resistant Melanoma P-728 EACR25-1808 Sujoy Bhowmik Poster Presenter India Clonal evolution of metastasis in ovarian and colorectal cancers P-729 EACR25-1820 Solveig Knoph Klokkerud Poster Presenter Norway Longitudinal Dynamics of Transcriptome and Chromatin Accessibility in Ovarian High‐Grade Serous Carcinoma P-730 EACR25-1912 Daria Afenteva Poster Presenter Finland Tumor subclonal heterogeneity as a cause of drug resistance in ovarian cancer P-731 EACR25-1970 Susanna Holmstr Poster Presenter Finland Rhabdomyosarcoma tumours undergo endothelial trans-differentiation to evade treatment P-732 EACR25-2014 Joseph William Wragg Poster Presenter United Kingdom Investigating the Role of Chromosomal Instability in Colorectal Cancer Drug Resistance Development P-733 EACR25-2144 Annie Dinky Gallagher Poster Presenter United Kingdom Tackling gastric cancer heterogeneity using patient-derived organoids P-734 EACR25-2436 Vivian Mittn Poster Presenter Germany Comprehensive molecular landscape of acquired resistance to sotorasib in pancreatic cancer P-735 EACR25-2530 Abu-Bakr Adetayo Ariwoola Poster Presenter Brazil Spontaneous telomere dysfunction promotes acrocentric chromosome arm fusions and aneuploidy in cell cycle checkpoint impaired human astrocytes P-736 EACR25-2594 FLORIS P BARTHEL Poster Presenter United States Poster and Exhibition Hall
10:45 20:00	TUMOUR IMMUNOLOGY TRIB1 leads to M2 skewing of macrophages in LUSC P-737 EACR25-0008 Dingyu - Lu Poster Presenter Germany New mouse models to define the function of CCR7+ dendritic cells in anti-tumour immunity P-738 EACR25-0118 Maria Koufaki Poster Presenter United Kingdom Five dominant amino acid substitution signatures shape tumour immunity P-739 EACR25-0154 M Poster Presenter Hungary Tumor-associated Staphylococcus spp. and its potential role in breast cancer progression P-740 EACR25-0344 Giancarla Bernardo Poster Presenter Italy Distinct bladder tumor microbiome profiles between responders and non-responders to intravesical Bacillus Calmette-Guérin therapy in high-risk non-muscle invasive bladder cancer P-741 EACR25-0418 KyungHwan Kim Poster Presenter Korea (Republic of) Prognostic Significance of NK-T Cell Differentiation in Oropharyngeal Squamous Cell Carcinoma: A Transcriptomic Analysis P-742 EACR25-0462 Luka Minarik Poster Presenter Croatia Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an IMMUCAN project P-743 EACR25-0542 Daniel Herrero Saboya Poster Presenter France Immune landscape of a SHH medulloblastoma mouse model: a preclinical platform for Immuno-Oncology studies P-744 EACR25-0636 Patr Poster Presenter Portugal Oncogenic MYC depletes amino acids from the tumor microenvironment to foster immune evasion in PDAC P-745 EACR25-0712 Bastian Krenz Poster Presenter Germany Impact of smoking status on microbiome diversity and taxonomic shifts in bladder cancer P-746 EACR25-0722 KyungHwan Kim Poster Presenter Korea (Republic of) Cancer vaccines target to a disintegrin and metalloprotease domain (ADAM) could induce anti-tumor immunity P-747 EACR25-0728 Shih-Jen Liu Poster Presenter Taiwan Advancing treatment in high-grade serous ovarian cancer through targeting of RNA splicing P-749 EACR25-0866 Aitana Cheesman Poster Presenter United Kingdom An integrated organoid and stool-derived culture platform for investigating microbiota-driven metabolite effects in colorectal cancer P-750 EACR25-0888 Nicholas James Bodenstein Poster Presenter Germany Osteopontin reprogrammes macrophages to a dysfunctional state in intrahepatic cholangiocarcinoma for patients with longer survival outcomes on chemotherapy. P-751 EACR25-0906 Marvelmario Reginald Gabriel Poster Presenter Denmark Translation Dysregulation In Cancer as a Source for Targetable Antigens P-752 EACR25-0944 Osnat Bartok Poster Presenter Israel 16S rRNA sequencing based characterization of human gastric microbiome in patients with autoimmune anthropic gastritis and gastric neuroendocrine tumors P-753 EACR25-0960 Helvijs Niedra Poster Presenter Latvia Unraveling Tissue-Resident Memory to Combat Metastatic Breast Cancer P-754 EACR25-0994 Daniela Filipa Amaral-Silva Poster Presenter Portugal Analysis of intratumor immune heterogeneity reveals spatial organization of immunosuppression in breast cancer P-755 EACR25-1070 Christina Metoikidou Poster Presenter Netherlands Taming the metabolism of tumor associated macrophages to fight NF1-related tumors P-756 EACR25-1218 Ionica Masgras Poster Presenter Italy IL1RAP targeting is a new therapeutic strategy for advanced triple negative breast cancer P-758 EACR25-1396 Marcela Garz Poster Presenter Spain LIF promotes immunosuppression through C1q+ TAMs in GBM P-759 EACR25-1408 Mar Poster Presenter Spain Decoding Immune Evasion in Mismatch-repair Deficient Colorectal Cancer Organoid-Immune Co-culture Models P-760 EACR25-1442 Monika Madrova Poster Presenter United Kingdom Immune surveillance is actively impaired by the secretome of mismatch repair proficient colorectal cancers P-761 EACR25-1534 Sharon Scardellato Poster Presenter Italy Integrative molecular and spatial analysis of intratumoral tertiary lymphoid structures: insights into immunotherapy response P-762 EACR25-1540 Barbora Tunkova Poster Presenter Czech Republic Develop feeder-free differentiation of human hypoimmunogenic iPSCs into natural killer (NK) cells with cytotoxic potential for advanced hepatocellular carcinoma (HCC) treatment P-763 EACR25-1578 ChenKai Yen Poster Presenter Taiwan Mapping T Cell Diversity in Sarcoma P-764 EACR25-1628 Barbara Betz Poster Presenter Germany NKG2A inhibition promotes NK cell-CD8+ T cell interactions in support of improved anticancer immunity in ovarian carcinoma P-765 EACR25-1674 Jitka Palich Fucikova Poster Presenter Czech Republic Integration of Bacterial and Fungal Microbiota and Lipidomic Data in Consecutive Saliva and Stool Samples of Lung Cancer Patients P-766 EACR25-1742 Ayse Caner Poster Presenter Turkey Making ‘cold’ tumors ‘hot’: ERAP1 modulation as an innovative strategy to enhance tumor immunogenicity P-767 EACR25-1758 Paula Gragera Poster Presenter Italy Eosinophil deactivation by the breast tumor microenvironment can be reversed by interferons P-768 EACR25-1862 Zofia Varyova Poster Presenter United Kingdom Non-haematopoietic cell drivers of immune-dysfunction in Hepatocellular carcinoma P-769 EACR25-1872 Angela L Ferguson Poster Presenter Australia Exploring the dual role of Toll-like receptor 2 in tumor cell autonomous and microbiota-driven chemoresistance in breast cancer P-770 EACR25-1898 Chiara Cossu Poster Presenter Italy In-silico functional profiles of anaerobic bacteria in prostate cancer P-771 EACR25-1924 Seshadhri Subramanian Poster Presenter United Kingdom Unlocking Immune Resistance: The Role of PIRB Deletion in Pancreatic Cancer Therapy P-772 EACR25-1926 Alessandro Scagliotti Poster Presenter Italy Low-density neutrophils: a valuable clinical tool for monitoring breast cancer progression and treatment decisions P-773 EACR25-1984 Daniela Grosa Poster Presenter Portugal Investigate the effect of alcohol-altered proteins from extracellular vesicles on the immune response and initiation of oral cancer P-774 EACR25-2026 Rodrigo Gomes Bernardo Cruz Poster Presenter Brazil Low-density neutrophils as key mediators of breast cancer progression: Revisiting the role of arginase-mediated immunosuppression P-774A EACR25-2040 Bruna Filipa Correia Poster Presenter Portugal Tissue Microenvironment Shapes PMN-MDSC Function, Maturation, and NETosis Capacity P-775 EACR25-2054 Nicola Tumino Poster Presenter Italy Chemotherapy Modulates the Immune Microenvironment and Epigenetic Landscape in MLL-AF9-Driven Acute Myeloid Leukemia P-776 EACR25-2058 Antonella Santoro Poster Presenter Italy HLA-DR-expressing Cytotoxic T Lymphocytes as drivers of the effectiveness of T cell-based therapies in Breast Cancer P-777 EACR25-2060 Rute Salvador Poster Presenter Portugal Targeting CAIX in tumor microenvironment stimulates anti-tumor immune response P-778 EACR25-2090 Eli_ka _vastova Poster Presenter Slovakia Rapid and Ficoll-free Magnetic Isolation of Human Monocytes from Whole Blood in High Purity and Yield P-779 EACR25-2114 Isabel Gessner Poster Presenter Germany Two-in-One: New Opportunities for Autologous Co-Isolation of T and B Cells from Small Blood Samples P-780 EACR25-2120 Rebecca Konigsmark Poster Presenter Germany Tumor-Induced Modulation of Hematopoiesis in Colorectal Cancer P-916 EACR25-2148 Ana Luisa Machado Poster Presenter Portugal Differential Impact of Staphylococcus aureus Infection on Lung Cancer and Normal Bronchial Cells P-781 EACR25-2158 Deniz Ece Poster Presenter Turkey Notch3-Regulated miRNAs Target CXCR4 to Enhance Leukemic Cell Dissemination in T-ALL P-782 EACR25-2190 Claudia Varricchio Poster Presenter Italy The lipid droplet metabolic hub regulates human NK cell function P-783 EACR25-2230 Laura Surace Poster Presenter Germany Divergent Metabolic States of Circulating vs. Tumor-Infiltrating Lymphocytes in Cancer P-784 EACR25-2286 Paolo Ritter Poster Presenter Italy Enhancing immunotherapy in KRAS G12C-driven lung cancer through B cell responses and Tertiary Lymphoid Structure formation. P-785 EACR25-2294 Alicia Alonso de la Vega Poster Presenter United Kingdom Study on sex-based myeloid cell differences in a clinically relevant glioblastoma mouse model P-786 EACR25-2304 Arianna Sironi Poster Presenter Italy Exploiting 'Myeloid-Derived Suppressor Cells'-targeted therapies in pre-clinical models of Notch-dependent T-Cell Acute Lymphoblastic Leukemia P-787 EACR25-2318 Noemi Martina Cantale Aeo Poster Presenter Italy Carcinogenic Effects of UV Radiation on S. epidermidis Infected Keratinocytes and Melanoma Cell Line P-788 EACR25-2376 Ufuk Mert Poster Presenter Turkey Exploring the potential of common spliceosome mutations as biomarkers for directing immune checkpoint blockade therapies in myeloid malignancies P-789 EACR25-2394 Rebecca Briggs Poster Presenter United Kingdom The immunomodulatory role of tumor-derived extracellular vesicles in breast cancer: insights into dendritic cell dysfunction and immune evasion P-790 EACR25-2414 Brenda Raissa Oliveira Poster Presenter Portugal Screening of TCR-specific epitopes using peptide libraries in artificial antigen-presenting cells P-748 EACR25-2574 Alex Chenchik Poster Presenter Combination therapy with EPHA3 monoclonal antibody and anti-CD47 antibody reprograms tumor-associated macrophages to inhibit recurrent head and neck cancer P-791 EACR25-2584 MINSEOK KIM Poster Presenter Korea (Republic of) Poster and Exhibition Hall
10:45 20:00	LATE ABSTRACTS - Tuesday Cancer evolution of relapsed colorectal liver metastases after treatment P-792 EACR25-3002 Soulafa Mamlouk Poster Presenter Germany Anti-tumor Effects of Targeting the SIN3A/KLF4 Complex to Induce KLF4 Acetylation in Gastric Cancer P-793 EACR25-3004 Zichao Guo Poster Presenter China Biomimetic Red Blood Cell Membrane-Coated FePt Metal-Organic Framework Nanoparticles: A Multifunctional Theranostic System for Enhanced MRI and Targeted Therapy P-794 EACR25-3008 Ming-Hsien Chan Poster Presenter Taiwan Identification of novel treatment targets in whole genome-doubled high-grade serous ovarian cancer P-795 EACR25-3014 Nikki Burdett Poster Presenter Australia Pharmacogenetic Profiling of the SLC31A1 rs10759637 Variant in a Spanish Cancer Immunotherapy Cohort P-796 EACR25-3016 Javier Oliver Poster Presenter Spain Potential role of LCN2, MMP9 and LCN2/MMP9 complex as plausible biomarkers of Oral Squamous Cell Carcinoma (OSCC) P-847 EACR25-3018 Smriti Suri Poster Presenter India Immunomodulatory tumour endothelial cell plasticity and responses to radiotherapy in lung cancer P-797 EACR25-3020 Ana Rita Pedrosa Poster Presenter United Kingdom The Importance of Vigilant Pre-Screening and Monitoring: A Case of Missed Adrenal Insufficiency in a Patient on Pembrolizumab P-798 EACR25-3022 Muhammad Nafiz Awlia Poster Presenter United Kingdom Transcriptomic signatures for induction chemotherapy response and organ functionality in advanced Laryngeal and Hypopharyngeal cancers P-799 EACR25-3026 Micaela Compagnoni Poster Presenter Italy Path2Space: An AI Approach for Cancer Biomarker Discovery Via Histopathology Inferred Spatial Transcriptomics P-800 EACR25-3030 Emma Morin Campagnolo Poster Presenter United States Evaluation of Cell Cycle Inhibition and Apoptosis Induction by Terminalia chebula in MCF-7 Breast Cancer Cells Using In Vitro and ln silico Approaches P-801 EACR25-3032 Ali Shati Poster Presenter Saudi Arabia CosMx® SMI Spatially Resolved Whole Transcriptome in FFPE Tissue – A Paradigm Shift for Tissue Analysis P-802 EACR25-3042 Mirko Corselli Poster Presenter United States Salinomycin Triggers Ferroptosis in Breast Cancer Stem Cells through Endoplasmic Reticulum Stress P-803 EACR25-3044 Clemence Duruel Poster Presenter France Accelerating target discovery: harnessing multiplexed CRISPR screening to investigate sensitisation to small molecule inhibitors P-804 EACR25-3046 Valentina Quarantotti Poster Presenter United Kingdom Enhancing Apoptotic Activity in Human Hep-2 Laryngeal Carcinoma Cells via Polyvinyl Alcohol–Stabilized Silver Nanostructures Under Exposure to Extremely Low-Frequency Electromagnetic Fields P-805 EACR25-3048 MOhammad Alfaifi Poster Presenter Saudi Arabia Pooled single-cell screening in colorectal cancer identifies transcriptional modules of clinical relevance unlocked by oncogenes P-806 EACR25-3058 Markus Morkel Poster Presenter Germany A Spatially Resolved Multi-Omics Atlas of Tertiary Lymphoid Structures and Tumor-Infiltrating Lymphocytes in Ovarian Cancer P-807 EACR25-3060 Zhihan Liang Poster Presenter Finland Novel combination therapy: Allium sativum L. with the chemotherapeutic drug, 5- fluorouracil for colon cancer P-808 EACR25-3062 Elizka van Heerden Poster Presenter South Africa Characterizing and targeting extracellular matrix proteins that contribute to breast survival in the lymph node P-809 EACR25-3064 Alanis Carmona Poster Presenter United States Integrative bioinformatics and functional validation reveal miR-642a-5p as a tumor suppressor regulating POFUT1 in colon cancer P-810 EACR25-3066 Oumaima MAZOUR Poster Presenter France Targeting the CSF-1/CSF-1R pathway to harness the immune system into fighting mesothelioma P-811 EACR25-3070 Rosanna Mezzapelle Poster Presenter Italy MYC targeting by Omomyc boosts efficacy and overcomes resistance to KRAS inhibitors P-812 EACR25-3080 Daniel Capit Poster Presenter Spain Identification of Tumor-Specific Exosomal miRNA Biomarkers in Colorectal Cancer Using Paired Pre- and Post-Operative Blood P-813 EACR25-3084 Seung Min Lee Poster Presenter Korea (Republic of) Synergistic Mechanisms of Genistein and Other Soy Isoflavones in MCF-7 Human Breast Cancer Cells In Vitro P-814 EACR25-3086 MISAKI ONO Poster Presenter Japan Monitoring of Tumor Microenvironment by Shear Wave Elastography, Contrast Enhanced Ultrasound and Photoacoustic Imaging using One Multimodal Imaging Platform P-815 EACR25-3090 Dieter Fuchs Poster Presenter Austria Assessing large-scale CAR-T cell cytotoxicity ex vivo using 2-D and 3-D multimodal imaging techniques for industrial standards P-816 EACR25-3098 Wan Li Low Poster Presenter United Kingdom NPY-Functionalized Erythrocyte Vesicles for Targeted Breast Cancer Therapy P-817 EACR25-3100 Katarina Tomic Poster Presenter Slovenia Partitioning of the functional contributions of Stat3 and Myc to gastric tumour development in mice P-818 EACR25-3108 Matthias Ernst Poster Presenter Australia Glycosylated Calnexin is an effective target for Gastro-intestinal Cancers P-819 EACR25-3112 Development of post-surgical local delivery systems based on polymeric nanofibers for the administration of antineoplastic drugs against glioblastoma P-820 EACR25-3116 Pedro Valent Poster Presenter Spain Single-cell resolution ecDNA mapping reveals pan-cancer ecDNA modules accompanying clonal selection in cancer metastasis P-821 EACR25-3120 LIANG WU Poster Presenter China CRISPR activation screen identifies novel drivers of proteasome inhibitor resistance in multiple myeloma P-822 EACR25-3122 MARIANGELA PORRO Poster Presenter Italy A Rapid, Fully-Automated, and Cost-Effective Clinical Whole Genome Sequencing Solution P-823 EACR25-3124 Bret Wurdeman Poster Presenter Assessment of a porphyrin cellular uptake in cancer cells P-824 EACR25-3126 Justyna Anna Sykula Poster Presenter Poland Integrative Multi-omics Analysis of Exosomes in Lung Cancer P-825 EACR25-3128 Daniel Gomez-Cabello Poster Presenter Spain Microfluidic-Assisted Fabrication of Magnetically Guided, Dual-Drug-Loaded Silk Fibroin Nanoparticles for Breast Cancer Therapy P-826 EACR25-3130 Muhamad Hawari Mansor Poster Presenter United Kingdom CHARACTERIZATION OF THE tRNAS OF LUNG CANCER STEM CELLS P-827 EACR25-3132 Sharon Brembati Poster Presenter Belgium The role of TMEM97/PGRMC1/sigma-2 receptor for Siramesine – a sigma 2 ligand - and DNA damage effect of Siramesine in Pancreatic Ductal Adenocarcinoma (PDAC) P-828 EACR25-3134 Fani Koutsougianni Poster Presenter Greece The PDK-1 inhibitor GSK2334470 induces cell death and G0/1 cell cycle arrest in human pancreatic cancer cells P-829 EACR25-3136 Fani Koutsougianni Poster Presenter Greece Genetic models of breast cancer reveal distinct roles for apoptotic regulators in tumour initiation, growth and metastasis P-830 EACR25-3140 Kirsteen Campbell Poster Presenter United Kingdom Epiploic Appendagitis in a Breast Cancer Patient on Abemaciclib: A Rare Case and Diagnostic Considerations P-831 EACR25-3142 Muhammad Nafiz Awlia Poster Presenter United Kingdom Liquid Biopsy for Glioblastoma: Plasma Extracellular Vesicles for Tumor Diagnosis, Monitoring, and Patient Stratification P-832 EACR25-3158 Massimiliano Del Bene Poster Presenter Italy Metabolism-targeted therapy in NSCLC: a novel inhalation approach using lactate-functionalized, selenium–chrysin-loaded nanoparticles (SeChry@PUREG4-LA24) P-833 EACR25-3160 Cindy Mendes Poster Presenter Portugal Quantum Nuova by QT Sense: High-Sensitivity Single-Cell Analysis for Cancer Research and Personalized Medicine P-834 EACR25-3162 David Hueting Poster Presenter Netherlands A multiscale atlas of metastatic growth and immune evasion in anatomical niches P-835 EACR25-3164 Gina Dunkel Poster Presenter Germany Integrative Precision Medicine Algorithms to Predict Treatment Response in Bladder Cancer P-836 EACR25-3180 J Poster Presenter Spain Hypoxia-Driven Extracellular Vesicles Promote Pro-Metastatic Signalling in LNCaP Cells via Wnt and EMT Pathways P-837 EACR25-3182 Melissa Santos Poster Presenter United Kingdom Discovery of pancreatic cancer biomarkers in liquid biopsies: an innovative method for salivary exosome processing and characterization P-838 EACR25-3184 Lucia Piazza Poster Presenter Italy A 3D tumor-on-a-chip platform to identify drugs that block circulating tumor cell release P-839 EACR25-3186 Ana Lu Poster Presenter Portugal Dissecting the Roles of IL-1 Family Cytokines in Systemic Immunosuppression and Neutrophil-Mediated Immune Dysfunction P-840 EACR25-3188 Morgane Lecointre Poster Presenter Switzerland Gene mutant dosage determine prognosis and metastatic tropism in 60,000 clinical cancer samples P-841 EACR25-3190 Nicola Calonaci Poster Presenter Italy Revolutionizing Radiobiology: 3D Models for Breast Cancer Research P-842 EACR25-3192 Fl Poster Presenter Portugal TAS1R3 membrane receptor in lung cancer: Development of a molecular toolbox for the study of its potential as a therapeutic target P-843 EACR25-3204 Mar Poster Presenter Spain Histopathological Characterization of Tertiary Lymphoid Structures across Ovarian Cancer Histotypes and Molecular profiles in Ovarian Cancer. P-844 EACR25-3206 Hanna Elomaa Poster Presenter Finland Preliminary in vitro investigation of Alginate/Gelatin Hydrogels-based Bioinks for Breast Tumor P-845 EACR25-3208 Amirhossein Elahi Poster Presenter Italy Engineering chromosomal instability via BRCA1/2 knockout in vitro P-846 EACR25-3216 Blas Chaves-Urbano Poster Presenter Spain Poster and Exhibition Hall