POSTER SESSION - Tuesday

HALO Breast IHC AI: Demonstration of its Application as a Training Tool for Students

From Transcriptomic Data to Therapeutic Potential: Drug Repositioning for Papillary Thyroid Carcinoma

MetaboDynamics: a Bioconductor package for the probabilistic analysis of longitudinal metabolomics data

Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy

Deep Learning-Based PET Synthesis from CT Scans: Advancing Abdominal Lymph Node Metastasis Assessment

Weave: a software package for integrated spatial multi-omics visualization and data analysis

Optimizing Chemoradiotherapy for Malignant Gliomas Using a Validated Mathematical Model and In Silico Trials

Multi-Cancer Early Detection and Tumor localization in Women Using Metabolomics-Based Machine Learning Models

Computational identification of pan-cancer multi-omic metabolic signatures as prognostic biomarkers and therapeutic targets

Using the CancerHubs approach and web application to define novel cancer-related protein interaction hubs

A Smart Platform for Cancer Research: Integrating Consensus Meta-Analysis of Omics Data with Ontology-Based Network Analysis

Panoptic Segmentation and Spatial Analysis of Whole Slide Images: A Unified Open-Source Framework

Developing an artificial intelligence model for clinical benefit prediction in breast cancer

Co-dysregulation of Redox and Ca²⁺ homeostasis-associated genes and its prognostic significance in Breast Cancer

Artificial intelligence-based pathological analysis for Gleason grade and tumor quantification in prostate cancers

Predicting drug response from omics data using MultiOmic2Drug

Novel clustering of glioblastoma patients with EGFR mutation by unsupervised machine learning

MetaAnalysisOnline’s Network Tool: Simplifying Network Meta-Analysis for All Researchers

Enhancing Mutational Signature Detection in Whole Exome Sequencing: Insights from Esophageal Squamous-Cell Carcinoma

Single Cell Transcriptomics Reveals Hallmark Enrichment in Luminal A and Triple Negative Breast Cancers

Linking in situ phenotyping of intestinal stem cells to functional analyses of patient-derived organoids as a risk stratification strategy during follow-up monitoring of CRC patients

Good Models or Good Riddance: A Guide for Researchers on Choosing Optimal Cell Lines for Translational Ovarian Cancer Research

Prediction of Rectal Cancer Complete Response to Chemoradiotherapy by Multiscale Imaging and Deep Learning Analyses (PRECORMIDEL)

Development of a mathematical model for early prediction of relapses in colorectal cancer

Deciphering the Role of Stress Granules: Dampening Inflammation in Cancer through Mitochondrial RNA Sequestration

A semi-automated approach for detecting minimal residual disease with single-tube by flow cytometry in pediatric acute myeloid leukemia

Monte Carlo Simulation of Gold Nanoparticles in Glioblastoma Radiotherapy: Impact on Survival and DNA damage under Co-60 γ-radiation and 160 kVp X-rays

Deep learning in digital histopathology for clinically applicable biomarker discovery in prostate cancer

Unravelling HR-positive, HER2-negative Breast Cancer and its Tumor Microenvironment Heterogeneity Using Spatial Transcriptomics

Multiomic network-based modelling in Polish High-Grade Serous Ovarian Cancer (HGSOC) patients reveals prognostic importance of RAD21 and miR-4516

In-silico Approach to Uncover Biomarkers and Therapeutic Targets in Metastatic Oral Squamous Cell Carcinoma

Unveiling the spatial regulation of chemoresistance in ovarian cancer

Machine Learning-Driven Drug Repositioning for Oral Squamous Cell Carcinoma: A Predictive Approach Using Affinity2Vec

Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment

Spatially resolved OMICs defines specific immune-tumor niches in esophageal adenocarcinoma responders to neoadjuvant chemotherapy

TNMv2: online tool to perfrom stage specific gene expression analysis

Assessing the maturation stages of PMN-MDSC to dissect the immunosuppressive mechanisms within TME

Modelling Somatic Alterations with Protein Language Models

Development of a liquid biopsy test for Ovarian Cancer using Fragmentomic Characterization of blood samples.

YOLO-based approach for breast cancer tumour detection and segmentation in MRI scans

Characterizing Aggressiveness of Prostate Cancer with Large-scale DNA Organization Image Analysis

RabAnalyser: a computational framework to measure the cell-to-cell variability of Rab GTPases organization

Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics

Detection of Circulating Tumour DNA (ctDNA) with ddPCR and NGS in Liposarcoma

The systemic inflammation response index (SIRI) may identify less toxic treatments for specific advanced pancreatic adenocarcinoma patients

miR-7974: A predictor of poor prognosis and link to autophagy in ER+ breast cancer

Unravelling predictors of response to dual HER2 blockade in HER2+ metastatic breast cancer using single-cell peripheral immune profiling

Czech Metastatic Colorectal Cancer Patients: their Copy Number Variation and Clinical Response to Chemotherapy and Bevacizumab

Colorectal cancer patients comprehensive genomic profiling using TruSight Oncology 500

AREG or EREG Overexpression Identifies a Subset of Gastro-Esophageal Adenocarcinoma Patients Responsive to EGFR Targeting

LGALS3BP’s role in bladder cancer: a potential urinary biomarker and therapeutic target

Detection of high molecular weight DNA contaminations in cell-free DNA samples

Liquid Biopsy-Based Biomarkers for Predicting Radiotherapy Response in Locally Advanced Head and Neck Squamous Cell Carcinoma

Serum metabolomic profiling unveils a metabolite marker panel for early detection of colorectal cancer

Detection rate for ESR1 mutations is higher in circulating-tumor-cell-derived genomic DNA than in paired plasma cell-free DNA samples as revealed by ddPCR

THOR Methylation signatures in liquid biopsies for early breast cancer detection

Integrating tumor fraction, next generation sequencing and qPCR analysis in liquid biopsy of EGFR-mutated non-small cell lung cancer patients

Evaluation of a novel protein-based assay for multi-cancer early detection

A novel therapeutic approach for metastatic medulloblastoma

Changing the paradigm of liquid biopsy storage without cold chain. In-vitro validation of a preservative medium for circulating tumor HPV-DNA stabilization.

Non-Invasive Detection of Circulating mRNA Markers in Colorectal Diseases

The expression of the tight junctional protein complex Occludin (OCLN) and Zonula Occludens 1 (ZO-1) in human colon cancer and assessment of disease progression and therapeutic responses

Predicting Second-Line Chemotherapy Outcome in Advanced Pancreatic Cancer: A Machine Learning Approach Using PBMC-Based Biomarkers - Translational Findings from the PREDICT Trial

Elevated monocyte-lymphocyte ratio as a prognostic and predictive biomarker of poor response to radio-immunotherapy in advanced cancer: correlation with immune and metabolic dysregulation

Characterization of miRNA profiles in different subtypes of colorectal adenomas in tissue and fecal samples

Differential protein expression in platelets collected from glioma patients and healthy controls: A Comparative Study

Unraveling Tumor Genetics: The Role of cfDNA Whole-Exome Sequencing for Tracking Tumor Evolution and Treatment Response

Establishing a plasma protein signature for clear cell renal cell carcinoma

Aberrant miRNA expression in papillary thyroid carcinoma– clinical applications

Patient-specific cell-free RNA alterations enable cancer classification

ddPCR as molecular approach to assess MSI-H status in PDAC EUS-FNB samples

microRNA profile associated with the aggressive potential of salivary gland mucoepidermoid carcinoma

Immune-Related Gene Signature in Melanoma Lymph Node Metastasis: A 6-Gene Predictive Model

Improving Cancer Screening and Monitoring: The Potential of Oncofetal Chondroitin Sulfate Proteoglycans in Liquid Biopsies

Profiling immunological signatures in the peripheral blood of patients with stage III non-small cell lung cancer treated with chemoradiation and adjuvant durvalumab

Fecal miRNA profiles and gut metagenome composition in Lynch syndrome: results from a study on human subjects and a mouse model

Monitoring Cystatin F Dynamics in Melanoma Patients Undergoing Checkpoint Inhibitor Therapy

Defining blood-based immune biomarkers to improve early lung cancer detection during community lung health checks

Extracellular Vesicle-Associated miRNA downregulation dynamics during acquisition of enzalutamide resistance: implications for early detection and RNA-based therapeutic opportunities

Inertial Microfluidics for Circulating Tumor Cell (CTC) Separation with Serpentine Channels: A Numerical and Experimental Study

Capturing the Full Spectrum: High Dynamic Range Biomarker Detection with Photon Upconverting Nanoparticles

Optical Genome Mapping for detecting Homologous Recombination Deficiency in breast and ovarian cancers

Combined microfluidic isolation and immunofluorescence staining of circulating tumour cells for the assessment of Androgen Receptor expression in metastatic Prostate cancer blood samples.

Unveiling the Role of Extracellular Vesicle miRNAs in HCC Pathogenesis and Therapy

Comparative molecular analysis of CTCs and cfDNA Detection using Parsortix® System

Machine Learning Analysis of cfDNA Fragment Patterns from Minimal Coverage Whole Genome Sequencing Data for Cancer Detection

MicroRNAs for the Detection of Basal Breast Tumor Subtype.

Systemic dissemination in glioblastoma multiforme patients

Circulating miRNAs prognostic signature in bladder cancer: integrative analysis in patient-derived xenografts (PDXs) and cancer patients

Elevated miR-21-5p Expression as a Prognostic Biomarker in Cervical Cancer: Insights from the Indian Patient Cohort

miRNA profiling in bile extracellular vesicles from cholangiocarcinoma patients

Detection of circulating metastasis-initiating cells predicts therapy efficacy and prognosis in lung cancer patients treated with neoadjuvant chemotherapy.

Leveraging MicroRNA Biomarkers to Dissect PD-L1 Regulation and Improve Immunotherapy Response in Lung Cancer

Novel blood-based protein biomarker signature for early detection of colorectal cancer and advanced adenomas

Extracellular Vesicles in Stool: Unlocking New Protein Biomarkers for Colorectal Cancer and Premalignant Lesions

Downregulation of MicroRNA-497-5p Promotes Tumor Cell Malignancy and Contributes to Hepatitis B Virus-Related Hepatocellular Carcinoma Recurrence

The integrated stress response drives MET oncogene overexpression in cancers

Effects of the anti-diabetic dipeptidyl-peptidase 4 inhibitor on radiation response in breast carcinoma cells with different metastatic potential

Unique lipidomic signature in colorectal adenocarcinoma

Characterizing Bladder Cancer Cells: Morphological and Biophysical Signatures for Advanced Label-Free Detection

Studying Stem Cell Fate & Plasticity in Pre-cancerous Gastric Organoids

Increasing autophagy activity suppresses Helicobacter pylori related gastric cancer tumorigenesis

Intracellular Ca2+ depletion induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane resulting in accelerated G2/M cell cycle transition

Using organoids and Drosophila to explore the role of protein kinase N as an intestinal tumour suppressor

Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using two-dimensional and three-dimensional in vitro culture models

ADAR2-dependent editing activity induces the differentiation of osteosarcoma cells by targeting IGFBP7

Constituent compounds from Bazi Bushen regulate autophagy and improve the senescence feature of vascular endothelial cells

Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C.

Exploring the Tumor-Suppressive Role of MLN51 (Metastatic Lymph Node 51) in Lung Adenocarcinoma

PFKFB4 mediates cell migration through regulating MX1 and MX2 expression in oral squamous cell carcinoma

Epigenetic regulation by histone modification in the epithelial-to-mesenchymal transition of lung cancer brain metastasis

A multi-omics approach to dissect cell-intrinsic functions of IDO1 in ovarian cancer

Deciphering the Breast Cancer Metastasis Transcriptome: A Deep Dive into the Enigmatic Role of Circular RNAs.

Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma

Sesamin inhibits human colorectal cancer HCT-116 cell growth by inducing apoptosis

KSRP-mediated Wnt/β-catenin activation promotes follicular thyroid cancer progression and stemness

The Effect of RG7388 and Etoposide Combination on Cell Death in a Neuroblastoma Cell Line

"FastM": a fasting-mimicking cell culture medium for refined cancer research

Investigating COPZ1 dependency in in vitro murine models of Thyroid Cancer

Regulation of EMT by the U-BOX Domain of CHIP/STUB1 in Colon Cancer Cells

Macroautophagy as a hallmark in colorectal cancer

Novel 1-benzhydryl piperazine scaffold-based HDAC inhibitor b7 induces synergistic antiproliferative effect with vemurafenib in colorectal cancer cells harboring BRAF mutation

LOXL2 Inhibition: A New Strategy for Triple-Negative Breast Cancer

Nutlin-3a Inhibits Lysosomal Fusion by Inducing SNARE Dysfunction in KRAS mutant/p53 Wild-Type Lung Cancer

Heterogeneous and dynamic response of squamous esophageal cancer to CDK4/6 inhibition.

TACSTD2 expression is a marker for the early formation of colon adenoma

Beta-catenin differential expression in salivary gland tumors from intercalated duct: an immunohistochemical and molecular study

Repurposing Antihistamines: Exploring Their Potential as N-WASP Inhibitors in Breast Cancer Metastasis

Western diet-associated colonic insulin resistance boosts DNA error-prone quiescent stem cells and senescence of the homeostatic LGR5+ stem cells in the colon

Low-density lipoprotein receptor-related protein 11 promotes lung adenocarcinoma proliferation by suppressing ubiquitin like modifier activating enzyme 7

Deciphering how the TRMP7 channel is involved in breast cancer modulation

Investigation of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene

Role of the antioxidant metabolism (AM) at various EMT/MET states of pancreatic ductal adenocarcinoma (PDAC) cells

Targeting KDM4-Driven Metabolic Reprogramming in Castration-Resistant Prostate Cancer

Urea cycle upregulation is a metabolic adaptation driving liver-specific metastatic organotropism

Restoration of Drug Sensitivity and Apoptosis to Drug-Resistant Oesophageal Cancer Cells by USP18 Knockdown in the Presence of IFN-α or Poly (I:C)

Epithelial Protein Lost in Neoplasm (EPLIN) in Head and Neck Cancer: A Prospective Oncogenic Molecule Linked with Prognosis

Discovering Potential Anti-Oral Squamous Cell Carcinoma Mechanisms from Kochiae Fructus Using Network-Based Pharmacology Analysis and Experimental Validation

Therapy-induced senescence of bone-marrow mesenchymal stem cells contribute to increased cell invasiveness, stemness, vascular mimicry and macrophages recrutiment in TNBC by inducing PD-L1 overexpression

Aged-dependent metabolic reprogramming of microglia as a determinant factor in the development and progression of brain metastases

Molecular and Epigenetic Signatures of Senescence: Investigating Clonal Expansion and Chromatin Remodeling in HUVECs

Targeting CKAP2 to boost Chemotherapy Efficacy and alleviate immunosuppressive environment in non-small cell lung cancer

Regulation of Cancer Stemness by Hypoxia-Induced Metabolic Shifts and BNIP3-Driven Mitophagy in OECM-1 CSCs

Colon cancer cells metabolic plasticity: oxidative metabolism helps cancer cells to survive under glucose-deprivation

OXPHOS targeting of MYCN-amplified neuroblastoma

Targeting cell cycle vulnerabilities and signalling rewiring in p53 deficient cancers

TARGETING FATTY ACID OXIDATION TO BOOST THE ANTITUMOR EFFECTS OF NUTRIENT STARVATION IN SOLID MALIGNANCIES

PSRC1 promotes oncogenic dedifferentiation in TP53-mutated hepatocellular carcinoma

Activation of the p38/AP-1 Signaling Pathway by PFKFB4 Promotes ANXA2 Expression and Osteosarcoma Metastasis

Interconnections among MET tyrosine kinase receptor, NMDAR, glutamine metabolism, and stress response in cancer progression

Plasticity of esophageal progenitors in fine-tuned by their microenvironment in vivo

Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho

Pathophysiological Mechanisms of Pancreatic Islet Dysfunction in Pancreatic Ductal Adenocarcinoma

Degradation of IDH1 via Chaperone-mediated autophagy inhibits cell cycle progression in glioblastoma

Increased OGT activity promotes nuclear localization of RNA polymerase II to support oncogenic transcription

AHSG exacerbates malignant progression in lung adenocarcinoma through ubiquitination mediated degradation of GSK3β

The effect of Ibuprofen on autophagic gene expression in Hepatocellular Cancer

Mechanisms regulating the formation of colorectal cancer brain metastasis

Senescence Induction Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy

Impact of 5-Ethynyl-2′-deoxyuridine (EdU) on Chaperone-Mediated Autophagy and Key Cellular Processes in U-87MG Glioma Cells

Comparative analysis of regorafenib's effects in human and canine osteosarcoma cell lines: an interdisciplinary and translational perspective on bone tumor therapy

Metastatic ovarian cancer drives fundamental tissue reprogramming in the human omentum

Mechanisms of AICAr-Induced Acute Myeloid Leukemia Differentiation: Role of Ribonucleotide Metabolism and Replication Stress

CFTR modulator drugs can reduce the invasive properties of colorectal cancer cells

TGF-β induced EMT may promote tolerance of mitotic errors and genomic instability through inhibition of p53/p21pathway.

Investigating the effects of culture medium derived from HEK293 cells expressing DDB2^PCNA- protein on microenvironment.

The RHO exchange factor VAV3 shows unexpected tumor suppressor roles in non-small cell lung cancer

Identification of TGM2 as a Key Mediator of Autophagy-Driven Chemoresistance in p53-R282W expressing Cancer Cells

FGF/FGFR System in Medulloblastoma: New Approaches for Tumor Treatment.

Modulation of CITED2 Expression Unveils Different Biological Functions in Glioblastoma

Elucidating how nutrient dynamics in the tumor microenvironment modulates cancer metastasis

Crosstalk between autophagy and apoptosis induced by unsymmetrical bisacridines in pancreatic cancer cells

Trigger ferroptosis in breast cancer cells (BC) by targeting xCT and FATP1

Cell-cell adhesion disruption promotes stress granules formation: A survival strategy in Inflammatory Breast Cancer

Dual Cyclin-CDK Inhibition by Plant-Derived Hexadecanoic Acid Triggers G1/S Arrest

The impact of the microsporidia Encephalitozoon intestinalis on colorectal carcinogenesis

Therapeutic approaches to primary NRAS-driven leptomeningeal melanoma

Investigating the Therapeutic Potential of Antidiabetic Drugs, Metformin and Canagliflozin, in Papillary Thyroid Carcinoma

Deciphering the Role of Gasdermin B and D in Endometrial Cancer: A Multidisciplinary Approach

Characterization of Patient-derived xenograft (PDX) - derived organoids (PDXOs) to Find New Treatment Strategies for LKB1-Mutated NSCLC

Ferredoxin 2 is critical for tumor suppression and lipid homeostasis but dispensable for embryonic development

Modeling gastric intestinal metaplasia in organoids: role of TP53 loss-of-function

Epigallocatechin gallate (EGCG) augments the anti-leukaemic effect of L-asparaginase in childhood B-cell acute lymphoblastic leukaemia cells

Age-related effects in cancer therapy are driven by local and systemic changes in immune response

Functional Characterization of UBX Domain Protein 7 (UBXN7) in Glioblastoma: Implications for Tumor Progression

NRF2 activation by myeloid cell-derived oxidative stress induces SNAI-driven EMT and metastasis in breast cancer

Serum-related Metabolic stress and Breast Cancer: Differential Responses in Metastatic versus Non-Metastatic Cells

Cytokine and chemokine screening reveals altered NK-DC-T cell crosstalk in the aged tumor microenvironment

Loss of LKB1 in non-small cell lung carcinoma favours EMT-independent metastasis

Kv1.3 potassium channel-linked signaling networks based on STAT3 function are crucial for melanoma tumorigenesis

Investigation of novel heterocyclic fused naphthalimides as DNA-intercalating agents with antitumor potential

Structural Regulation of Gasdermin B Cytotoxic Activity: Insights into its Potential as a Therapeutic Target in Cancer

Genetic ablation of NOX2 boosts anti-tumor immunity yet accelerates metastasis in the PyMT-MMTV breast cancer model

Targeting glycation stress in chemoresistant colon cancer: Effects on cancer stem cells

Identifying novel regulators of the BH3-only protein PUMA using whole genome CRISPR/Cas9 KO screens to enhance the efficacy of cancer treatment

Peroxidasin promotes epithelial-mesenchymal transition and invasion in metastatic melanoma

mTORC2 but not mTORC1 governs cellular metabolic landscape in Calreticulin (CALR) mutated myeloproliferative neoplasm (MPN)

Modification of β-Catenin by MCPIP1 endonuclease Activity regulates the metastatic potential of ccRCC

The pro-invasive MAP4 kinases promote tissue invasion and selectively modulate interactions with the neural TME in medulloblastoma.

Novel liposomal nanoformulations containing cannabidiol, celecoxib and 2,5-dimethylcelecoxib induce cell cycle arrest and apoptosis in glioblastoma cells

Understanding the role of desmoglein 2 in preserving the epithelial phenotype of breast cancer cells

Impact of androgen receptor expression on the efficacy of anti-androgen therapies in triple negative breast cancer

Exploring the oncogenic role of the deubiquitinase USP7 in pancreatic cancer using PROTAC technology

SUMOylation of S6K2 May Confer Its Stabilization Contributing To The Survival of Breast Cancer Cells

Identification of a novel gene-signature driver of cancer malignancy

Influence of imbalanced progesterone receptor isoforms on breast cancer metabolism-related protein expression

PIK3CA modulates oncogenic and stemness properties in Cervical Cancer

Luminal breast cancer cell migration is reduced by depletion of BCL6 transcriptional repressor

Screening for senolytics by live monitoring the cell fate of senescent cancer cells

LZTR1 acts as a potent tumor suppressor gene in liver cancer by safeguarding aberrant MAPK activity via posttranslational control of RAS GTPases

Metabolic Rewiring in Chemoresistant Pancreatic Cancer Redox Metabolism and Lipid Alterations

ADDITIVE EFFECT OF EQUOL ON CHEMOTHERAPEUTICS USING 3D BIOPRINTED COLORECTAL CANCER CELLS

Naringenin’s Role in Mitophagy and Apoptosis: A Study in Cancerous and Healthy Cells

Purine Synthesis as a Metabolic Bottleneck in TP53/KRAS Double-Mutant Lung Adenocarcinoma

Androgen receptor, Filamin A, and CXCR4: partners in crime in TNBC.

Anti-Cancer Effects of Haplophyllum tuberculatum Extract Against Triple Negative Breast Cancer

Exploiting inhibitors of histone deacetylase and metabolism for pancreatic cancer therapy

Seamless Capture Integration for Accurate NGS-Based Applications

DISSECTING THE MOLECULAR MECHANISMS UNDERLYING THE ERKi-ENTRECTINIB COMBINATION IN LKB1-MUTATED NSCLC

Mitochondrial dynamics control cancer cell migration

Induction of Chemoresistance through Oxidative Stress and Lipid Reprogramming in Colorectal Cancer Cells Exposed to Adipose Microenvironmentnt

Type I interferons suppress pancreatic cancer initiation

Age-specific factors determine brain metastasis growth and immunotherapy response

Description of genomic profiles in non-small cell lung cancer: the particular case of Wnt and NFkB pathways interaction

Preclinical Research on Posterior Fossa Ependymoma Group A: From Experimental Models to Therapeutic Strategies

The expression and clinical significance of serum exosomes miR-122 and miR-874 in patients with colorectal cancer

Expression of APOC3 in human colon cancer, the clinical and therapeutic value

Characterizing Circulating Tumor Cell and containing Cancer Stem Cell Heterogeneity in Pancreatic Adenocarcinoma: A Single Cell Perspective

Comparative analysis of genomic and clinicopathologic characteristics between multifocal and unifocal breast cancer patients by whole-exome sequencing

Spatiotemporal multi-omics uncover tumor ecosystem dynamics driving metastatic colonization

Machine learning-derived mutational signatures reveal distinct DNA repair pathway dysregulation and clinical outcomes in BRCA1/2 ovarian cancer

Single-cell analysis reveals tumor-driven immune microenvironment reprogramming that promotes lung adenocarcinoma metastasis.

Studying genomic evolution in colonic cell line models of mismatch repair deficiency.

CRISPR-Cas9 knock-out screening of lncRNAs highlights new therapeutic targets for cancer treatment

FUNCTIONAL EXPLORATION THE MOLECULAR MECHANISM OF THE REGULATION FACTORS WHICH ARE RELATED TO THE TUMORIGEN-ESIS AND PROGNOSIS OF COLORECTAL CANCER

Non-canonical ORF Translation in Neuroblastoma: A New Source of Therapeutic Targets?

Spatial transcriptomics in precancerous lesions of the colorectum

Cardiac metastasis: From spatial transcriptomics to targeted therapy

Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer

Recurrent endocervical polyps harbor UBE2A p.(Arg6Trp) mutation

Core2Edge: A Human Glioblastoma Organoid and Brain Slice Co-Culture Model Capturing Tumor Infiltration and Transcriptional Heterogeneity from Core to Single-Cell Dispersion

Deciphering the Timing of Somatic Driver Mutations in Early-Onset Breast Cancer

Metabolic relevance of p53 hotspot mutations in hepatocellular carcinoma

Exploring EGLN1 as a therapeutic target for KRAS mutated lung cancer: insights into mitochondrial modulation

Decoding the Molecular Complexity of HCC: Clonal Diversity, Functional States, and Tumor-Stroma Crosstalk

Single-cell sequencing analysis highlights the transdifferentiation potential of cancer cells in a neuroblastoma cell line

Dual mutations in ARID1A and PIK3CA drive aggressiveness and drug resistance in estrogen receptor-positive breast cancer

Same-cell spatial transcriptomics and proteomics expression at single-cell resolution to decipher melanoma cell state heterogeneity and relationships with the inflammatory microenvironment in metastas

Integrated multi-omics analysis identifies sex differences in muscle-invasive bladder cancer

Comprehensive genomic profiling and RNA-seq analysis reveal distinct genomic and transcriptomic signatures associated with treatment response in metastatic colorectal cancer (mCRC) patients (pts) enrolled in the NIVACOR trial

Novel replication stress signature predicts non-homologous end-joining association mediated by the MutSα complex

Glucocorticoid receptor as a prognostic factor in triple-negative breast cancer correlates with migratory signature at a single-cell level

Spatial profiling of matched adnexal and omental tumors in high-grade serous carcinoma

Phenotypic and genomic characterisation of single micronuclei

Unraveling the influence of risk factors on tumour evolution in clear cell renal cell carcinoma

Is it the T-cell to Macrophage Ration that matters for treatment in TNBC

Investigating the impact of PRUNE2 deregulation on prostate cancer

Unveiling plasma cell–tumor cross-talk to boost immunotherapy in microsatellite-stable colon cancer

Spatial Multiomics Reveals T-cell Activation and Exhaustion States in the Tumor Microenvironment 

Mutational Signature Profiling in KRAS Mutant Lung Adenocarcinoma: Variant-Specific Associations and Prognostic Implications

Decoding the Complexity of Prostate Cancer Evolution: Uncovering Heterogeneous Cell States by Integrative Approaches

Inhibition of the heat shock response enhances modulated electrohyperthermia effects in triple negative breast cancer mouse model

Prevalence of Chromosomal Alterations in Acute Leukemias: A Descriptive Analysis in the Colombian Population

Targeting Aurora Kinase A in Breast Cancer Brain Metastasis

Unraveling the role of LKB1 mutations in Non-Small Cell Lung Cancer brain metastasis formation

Genomic profiling of tumour and liquid biopsy melanoma samples with targeted next-generation sequencing

STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells

Genome-wide CRISPR screen identifies RAB14 as a new target for gastric cancer treatment

Beyond BRAF V600E: Revealing the Hidden Clinical Relevance of Uncharacterized BRAF Variants

Intra-Tumour Heterogeneity in Cutaneous Squamous Cell Carcinoma Assessed by Spatial Transcriptomics

The landscape of copy number intra-tumour heterogeneity in breast cancer and its impact on the tumour ecosystem

Microhomology-Driven Genomic Alterations in Ovarian Cancer

Mapping Therapeutic Opportunities in LUSC Through Targeted Compound Screening

Exposing G2/M Checkpoint Vulnerabilities: BUB1B and BUB3 as Essential Dependencies in Malignant Pleural Mesothelioma

Deciphering oncogenic gene regulatory mechanisms at nucleotide resolution using precision genome editing

Common Genetic Dependencies of Sonic Hedgehog Medulloblastoma (SHH-MB) variants are Regulated by the Non-Malignant Microenvironment

GEM-X Flex: Scalable and cost-effective whole transcriptome single cell analysis for cancer marker detection from FFPE tissue section slides

Advancing tumor characterization and immune phenotyping through multiomic in situ profiling of RNA and proteins

Extensive spatial heterogeneity of transcript variants in localised prostate cancer

Spatial transcriptomic insights into the influence of cancer-associated fibroblast profiles in oral cancer spheroids

Optimizing low input and high-throughput cell fixation for single-cell RNA sequencing with combinatorial barcoding

Heterogenous fusion transcript landscape in multifocal primary prostate cancer

Unraveling chemoresistance in breast cancer through circulating miRNAs in liquid biopsy

The TP53:AHR genetic interaction regulates MAGE:TRIM28 activity to prevent cellular transformation

Sex-Dependent Transcriptional Gene Expression in Urothelial Bladder Cancer

Spatial Transcriptomics for characterising pathologic response to FOLFOX regimen in colorectal Liver Metastases

Genomic Analysis of PARP Inhibitor Response in High-Grade Serous Ovarian Cancer: Insights from Whole Genome Sequencing

Unravelling the role of AP-1 transcription factor in DNA damage signalling and response (DDR), platinum and PARP inhibitor resistance in ovarian cancers

Targeting Replication Protein A (RPA) heterotrimeric complex to enhance platinum sensitivity and reverse PARP inhibitor resistance in ovarian cancers

Translational control in ovarian cancer: role of the glutaminyl-tRNA synthetase (QARS) in DNA damage response

Fibronectin leucine-rich transmembrane protein 3 is a potential driver of intrahepatic cholangiocarcinoma

The inter-relationship between arsenic exposure and oxidative stress biomarkers on the risk of cancer occurrence - A population-based cohort study

Alterations in laminin alpha2-chain impact melanoma progression

Weaponizing the CRISPR/Cas9 technology

Development of an ex vivo model to determine early transcriptional changes in breast cancer

A synergistic effect of RNF43 and BRAF mutations on colorectal carcinogenesis

Investigating the carcinogenic and epigenetic modulating effects of per- and poly-fluoroalkyl substances (PFAS) on breast cancer development

Obesity-Derived Circulating Extracellular Vesicles Promote Tumor-Stimulatory Functions of Stromal Fibroblasts in Breast Cancer

Sex differences in selection of somatic mutations in normal human bladder

Three- dimensional (3D) Cancer Microenvironment that Confers Chemoresistance to DNA Damaging Drug

Targeted Delivery of NVPBEZ235 conjugated to gold nanoparticles for Overcoming Gemcitabine Resistance in Triple-Negative Breast Cancer

In Silico Identification of Common Pre-existing Resistance Mechanisms to EGFR Inhibitors in Colorectal Cancer

A newly discovered mTOR-STAT3 pathway regulates calcium release and calcium-mediated apoptosis at the ER in Triple Negative Breast Cancer

Evaluate the potential sensitization effect and underlying mechanism of tyrosine kinase inhibitor on cisplatin resistance oral squamous cell carcinoma

Study of long non-coding RNAs in resistance to KRAS G12C inhibitors in lung cancers

Targeting the Non-Homologous End-Joining Pathway Sensitizes MDM2-Amplified Liposarcoma to Doxorubicin-Induced Senescence in a p53-dependent Manner

Regulation of FOXK2 by AKT in breast cancer cells: Serine 398 as a novel potential phosphorylation site

FOXK2 transcription factor in cancer: expression, function and potential as a biomarker

Targeting low fidelity polymerases to prevent acquired resistance mutations to EGFR-targeted therapy in lung cancer.

Inhibition of the extracellular signal-regulated kinase 5 (ERK5) increases EGFR expression and its nuclear localization in HCC, generating new targeting opportunities

mTORC1 Fuels Resistance but Unlocks Metabolic Kill-Switch in PI3K-Mutant Breast Cancer

Assessment of two new ROS1+ NSCLC patient-derived cell lines as in vitro models for TKI resistance studies

Discovery of Molecular and Epigenetic Candidates Underlying Chemoresistance of Colorectal Cancer

The mechanism of PPARα-mediated cholesterol metabolism in regulating paclitaxel resistance in ovarian cancer cells

AP-1 transcription factor is a targetable mediator of osimertinib resistance in EGFR-mutant non-small cell lung cancer

Overactivation of oncogenic signaling steers cancer cells toward less malignant phenotypes

CIC: The Master Regulator of Resistance to MAPK Pathway Inhibition

Unlocking New Therapies: Targeting GSDMB Overexpression in HER2-Positive Tumors

FGFR signaling as a key mediator of resistance to alpelisib/fulvestrant combination in PIK3CA-mutant luminal A breast cancer

Targeting Ferroptosis to Enhance the Efficacy of BRAF/MEK Inhibitors in Overcoming Resistance in Melanoma

Investigation of the expression of drug resistance genes after Sorafenib administration

Targeting CCL19/21-CCR7 axis to overcome resistance to ALK inhibitors in ALK+ lymphoma

T-cell receptor (TCR) diversity in buffy coat samples from blood of ovarian, vulvar squamous cell and cervical cancer patients

Genomic Instability and Epigenomic Dysregulation as Hallmarks of mCRC Therapy Resistance — Findings from Broad ctDNA Molecular Profiling (METACC)

Exploring potential strategies overcoming the PARPi resistance in the Olaparib induced MDA-MB-436 resistant model

BMI1 as a therapeutic target to overcome chemoresistance in high-grade serous ovarian cancer

Identification of microRNAs and their target genes associated with acquired resistance of primary melanoma cells to targeted therapy

Impact of Mechanical Stress and Confinement on the Alteration of Protein Expression and Emergence of Time-Dependent Resistance to Cisplatin

Uncovering Transcriptional Signatures of Differential Drug Response in Archetypical Malignant States in Metastatic Breast Cancer (MBC)

Overcoming P-glycoprotein-mediated resistance in tumor cells through copolymers for cytotoxic drug delivery

Dual targeting BRD4-CDK9 transcriptional complex as a potent therapeutic strategy in glioblastoma

Unraveling mechanisms of CDK4/6 inhibitors resistance in metastatic breast cancer

Immune infiltration is associated with favorable response to neoadjuvant chemotherapy and carboplatin in hormone receptor positive and triple negative breast cancer

Inhibition of the RNA-binding protein HuR reduces cell proliferation and promotes apoptosis in EGFR-TKI resistant NSCLC cells

Targeting PI3K/AKT Pathway Dysregulation in Triple-Negative Breast Cancer: Overcoming Alpelisib Resistance through Dual Inhibition

Endothelial-Derived CAFs Drive Chemoresistance via ERCC1-IL-17A Axis: A Novel Therapeutic Target in Tumour Microenvironment

miR-181a-5p and Caveolin-1 Express Inversely in HCC and Augment the Aggressive Phenotype of Sorafenib-Resistant HCC Cells

Overcoming Taxane Resistance Through PRMT5 Inhibition: Targeting Epigenetic Mechanisms

Unraveling tumor intrinsic responses: IFN-gamma predicts clinical immunotherapy efficacy and exclusively triggers apoptosis in solid tumors while sparing hematologic malignancies

Signaling Pathways affected by RAGE inhibition in vemurafenib treated melanoma cells

Berberine, a P-glycoprotein inhibitor, shows synergistic anti-cancer effect when combined with Dactolisib in Colorectal Carcinoma HCT116 cell lines

ELUCIDATING TOPOTECAN-RESISTANCE MECHANISM IN HUMAN BREAST MCF-7 CANCER CELLS AND PACLITAXEL CROSS-RESISTANCE BY DNA DAMAGE SIGNALING PATHWAY GENE EXPRESSION.

An epigenetic shift of CEMIP drives tumor metastasis and 3D spheroid fomation in Androgen-resistant prostate cancer

The effectiveness of EZH2 inhibitors in treating human papillomavirus associated cervical cancer and associated pathways

Early cancer detection has the potential to significantly improve treatment outcomes and survival rates.

Correlation with DNA methylation changes and chemoresistance in glioblastoma after mitochondiral transfer

EZH2 regulates cell identity in neuroendocrine-like prostate cancer by driving alternate transcription via activation of translation and RNA processing regulation.

Unraveling Inflammation-Related microRNAs in Pleural Mesothelioma: Gene Regulation and Pathway Analysis

Promoter methylation regulates CDHR5 and UPB1 expression in clear cell Renal Cell Carcinoma with sarcomatoid differentiation

Methylation profiles in cervical swabs: challenges in early diagnosis of ovarian cancer

IRF2BP2/TRIM28/DNMT1 suppresses transposable elements to maintain AML survival

KDM6A Regulates Sex Specific Immune Responses in Melanoma.

Multi-omics Study Identified Novel Oncogenic Roles of DNA-interacting Circular RNA as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Molecular profiling of uncharacterized Sex Cord-Stromal Tumors of the Ovary

High-throughput DNA methylation profiling of urological malignancies: defining epigenetic signatures in prostate, bladder and kidney cancers

Epigallocatechin-3-gallate as a potential epigenetic regulator of ALDH1 expression in colorectal cancer

Unraveling MLH1 promoter methylation and CpG Methylator Phenotype interplay in colorectal adenocarcinoma

Metabolic deregulation of TET/TDG DNA demethylation complex impairs base excision repair process promoting PDAC tumorigenesis

EZH2 inhibition: A Key to Unlocking the Notch-Driven Tumor Suppression in Acute Myeloid Leukemia

Promoter methylation identifies potential biomarkers for early detection of colitis-associated cancer

Multiomics assessment of lung adenocarcinoma subtypes defined through tumor purity-adjusted DNA methylation

Arid1a directs lineage specification in mammary epithelial cells

Targeting CBX2 disrupts DNA damage repair and mitosis regulation in glioblastoma – a novel therapeutic opportunity

Integrative Multi-Omic Analysis Reveals a Pax8-Driven Gene Network Linking Tumor Stemness to Therapy Response in Ovarian Cancer.

Functional impact of histone methyltransferase KMT2B in pediatric astrocytomas

Chromenone Derivatives as Potential CRM1 Inhibitors for Glioblastoma Therapy

IQS080 is a novel cytosolic multitargeted kinase inhibitor that simultaneously targets key kinase families, making it a promising candidate for the treatment of pancreatic cancer

Engineering Bacteriophages for Targeted Photodynamic Cancer Therapy

The anthelmintic drug rafoxanide promotes oxidative stress and VDAC1 opening, leading to mitochondrial dysfunction in colorectal cancer cells.

The synergistic effect of sedanolide and 5-fluorouracil on triggering mitochondria-dependent apoptosis in colorectal cancer cells

The interplay between melatonin and alpha-synuclein on melanoma biomolecular signatures

The anti-cancer activity of novel diazo-derived compounds on triple-negative breast cancer

Enhanced Efficacy and Targeted Delivery System of a pH-sensitive ARV-825 Nanomedicine for Glioblastoma Treatment

A genetic signature predicts the response of aggressive paragangliomas to dual PI3K and CDK4/6 inhibition.

PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors

Oxyresveratrol inhibits the tumorigenesis and metastasis of human HCC cells by targeting the CCDC19/PLK1/CCNB1 pathways

Integrative Pharmacogenomics in RCC Tumoroids Uncovers Biomarker-Driven Combination Therapies

Targeted Delivery of Extracellular Vesicles to Metastatic Breast Cancer Cells Using the Tumor-Targeting Peptide p28

Modulation of GPR55 and PINK1 in Glioblastoma Multiforme Models by Cannabis sativa and Piper nigrum Metabolites

Repurposing the antifungal piroctone olamine as a targeted treatment for pancreatic ductal adenocarcinoma

Discovery of DAC-1522, a novel Trop2-targeting degrader-antibody conjugate for precision oncology

Punicalagin-mediated suppression of oncogenic properties in ovarian epithelial adenocarcinoma cells

Risk and benefit for basket clinical trials in oncology: a systematic review with meta-analysis

Exploring the Cytotoxic Potential of Calcite on MCF-7 Cells: A Promising Approach for Breast Cancer Treatment

Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects

Investigating the Antitumour Potential of Fucoidan with Everolimus: An in vitro and in vivo Study Focusing on ERα/Akt/mTOR Pathway Suppression

High-Throughput Screening Identifies Novel Small Molecule Inhibitors of ELP3 with Potent Anti-Cancer Activity In Vivo

Novel Tamoxifen Derivatives Suppress Breast Cancer Growth and Alter Cancer-Related Gene Expression

A novel ribosome biogenesis inhibitor, PMR-116, displays broad spectrum efficacy in preclinical tumour models

Nanobiotechnological engineering of M13 bacteriophage for EGFR-targeted theranostics

KA103, a novel targeted toxin for Head and Neck Cancer

Evaluation of the antineoplastic effects of imipridone derivatives in prostate cancer: Novel therapeutic opportunities

Incorporation of disulfide bond into interleukin-2 for enhancing stability, solubility and therapeutic efficacy

In vivo delivery of gemcitabine through HPMA copolymer conjugates: slow drug release kinetics is crucial for potent antitumor activity

Zebrafish Avatar-test predicts tumor response to chemotherapy in Breast Cancer: A co-clinical study for personalized medicine

Effect of RID-A proteins in cachexia and tumor metabolism

Targeting BCKDK to Overcome Paclitaxel Resistance in Breast Cancer: A Novel Therapeutic Approach

Datopotamab deruxtecan plus PARP inhibition is highly synergistic in 2D and 3D ovarian cancer models

Targeted Treatment of Solid Tumors with BRAF Fusions

Long-term organoids derived from head and neck and ovarian cancer patients closely recapitulate tumor of origin and predict clinical outcome

Assay development for addressing drug resistance mediated by fibroblasts in ER+ breast cancer

Anisomelic Acid Suppresses HPV-Driven Tumor Growth with Potential TEAD2 Targeting: Evidence from a Xenograft Model and Proteomics

PTPN2/PTPN1 inhibition induces tumor eradication in ALK-positive lymphoma by triggering a combination of ALK-induced oncogenic stress and immune responses

The Superior Therapeutic Potential of Curcumin-Loaded Zinc Oxide Nanoparticles Against Bladder Cancer

Biological Basis for the Development of CPL410005 as an Antibody-Drug Conjugate

HSPGs targeting and multimeric cytotoxic conjugates as a novel PDC strategy against pancreatic cancer

Teaching cells the drug uptake – rational modulation of endocytosis for precise delivery of novel HSPGs targeting conjugate into pancreatic cancer cells

Expression analysis of CTLA-4, PD-1, and PD-L1 in non-small cell lung cancer patients receiving immunotherapy

Apoptotic Effects of a Flavone Combination on Brain Metastatic Triple-Negative Breast Cancer Cells

Integrating Proximity Ligation Assay for PD1-PDL1 Immunoassay with Multiplex Immunofluorescence Imaging in Urothelial Carcinoma

Type I and II BIR domains as targets for cancer therapy

Alpha-1 adrenergic antagonists to sensitize neuroblastoma over isotretinoin theraphy

Muscle-invasive bladder cancer organoids as a functional system to address therapy response: Perspective in advancing precision medicine

MESOPOROUS SILICA NANOPARTICLES FOR THE SELECTIVE DELIVERY OF DOXORUBICIN TO FOLATE RECEPTOR-EXPRESSING CANCER CELLS

Targeting UBE2N with Novel Non-Covalent Inhibitors: A Drug Discovery Approach to Combat PARPi Resistance in Ovarian Cancer

Multimodal targeting of Ephrin A2 in solid tumors using bi-cyclic drug conjugates

Tackling Hepatocellular Carcinoma with novel PROTAC Degraders of eIF6

A titanocene-derivative complexed with a myristic-like aliphatic chain exhibits antitumor activity in cisplatin-resistant models both in vitro and in vivo

EGFR-STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1-positive prostate cancer

Targeting CITK in high-grade brain tumors: a comparison of polypharmacological and specific inhibitors

Development of Lipid-Based Gene Delivery Systems for CAR T Cell Therapy

Oral liquid crystalline dispersion effect in chemotherapy-induced intestinal mucositis

Microneedle-mediated delivery of Iron Oxide Nanoparticles & Oxaliplatin with immune checkpoint inhibitors for its induction of ferroptosis and immunomodulation in Head and neck squamous cell carcinoma

Targeting RRM2: A Dual Approach to Apoptosis and Cell Cycle Control in Atypical Teratoid Rhabdoid Tumors

ALDH1 Isoform Landscape in Breast Cancer: Advancing Precision Therapies with a Potent ALDH1A3-Selective Inhibitor

AI and physics based methods to design biopharmaceuticals to fight triple-negative breast cancer

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

Mechanistic Insights into the Uptake, Trafficking, Drug Release, and Cytotoxic Efficacy of 5-FU/Irinotecan-Loaded core@shell Nanoparticles in Colorectal Cancer

A novel gene therapy combination targeting non-small cell lung cancer

Organ-on-chip platforms for assessing fasting-driven therapeutic responses in dynamic 3D tumor models

Oncofetal Chondroitin Sulfate represents a Target for Antibody Drug-Conjugate therapy of Acute Myeloid Leukemia

Engineering Subtype-Specific Breast Cancer Models: Decellularized ECM-Based Bioinks for Organoid Culture and Precision Oncology

Targeted drug delivery with erythrocyte-derived nanovesicles in an organ-on-chip tumor model

Extracellular Vesicles Loaded with miRNAs Target LCP-1 to Inhibit Tumor Growth and Metastasis in Triple-Negative Breast Cancer

Defining Docetaxel’s Antitumor Effects on Calu3 Lung Cancer Cells Using High-Throughput Live-Cell Imaging

Combination of PARP Inhibitor Olaparib and a Vascular Disrupting Agent Reduces Tumor Growth in a Xenograft Mouse Model of Prostate Cancer

Cellular response triggered by anticancer agent, C-2028 in breast cancer cells with different expression of key receptors under normoxia and hypoxia conditions

Polyoxovanadates with Anti-breast Cancer Activity and Ca2+-ATPase Inhibition Potential

Enhancing Therapeutic Efficacy in Patient-Derived Models of Pancreatic Ductal Adenocarcinoma Using Engineered Placental Mesenchymal Stromal Cells

Investigation of Novel Duocarmycin Payloads Antibody-Drug Conjugates (ADCs) targeting HER2 for Therapeutic Intervention

Triptonide induces pro-apoptotic effects against medulloblastoma subtypes

Doxorubicin and cGAMP-loaded hypoxia-sensitive polymersomes: A strategy for enhanced tumor growth inhibition and reduced systemic toxicity

The effects of a dual GIP/GLP-1 receptor agonist, Tirzepatide, on the response of prostate cancer cells to therapy

Exploring Polyoxotungstates as Novel Antitumor Agents for Pancreatic Cancer Therapy

Investigating the repurposing potential of cardiometabolic and hormonal medications for breast and ovarian cancer treatment using Mendelian randomisation

Overcoming Gemcitabine Chemoresistance in PDAC with Nanoparticle-Delivered Active Phosphorylated Gemcitabine

Combinations of HDAC and KRAS inhibitors in lung cancer

Subcutaneous controlled release of antibodies and antibody-drug-conjugates with zwitterionic chitosan-based hydrogels

Effect of doxorubicin and quercetin combined treatment on osteosarcoma model systems

Unlocking the Dual Power of miR-302b in BRCA1 Wild-Type Triple-Negative Breast Cancer: PARP Inhibitor Sensitivity Enhancer and Tumor Microenvironment Shaper

Targeted Metabolomics for Early-Onset Colorectal Cancer: Identification of Novel Therapeutic Targets and Biomarker-Driven Treatment Strategies

MASLiN as hydrophobic anticancer drug carrier: in vitro activity and in vivo biodistribution

Photodynamic therapy with ring-fused chlorins: a vision-preserving approach for retinoblastoma treatment

Exploring the impact of photodynamic therapy conditioning on endometrial cancer cells

The m6A RNA modification sustains neuroblastoma tumor aggressiveness

Evaluation of the effect of novel fascin inhibitors in patient-derived colorectal cancer organoids considering molecular and histological characteristics

Cold Atmospheric Plasma as a Potential Strategy to Target the Invasion and Metastasis Hallmark in Breast Cancer

Harnessing DNA repair to enhance therapy efficacy in myeloid leukemia: The impact of chronotherapy

Expression profiles of target genes for approved antibody-drug conjugates in the context of high-grade serous carcinoma

Alpha-aminobutyric acid attenuates DEN and diet-induced MASLD/MASH mice model by suppression of oncogenic signalling pathways KRAS, STAT3 via gut microbiome modulation

Combined siRNA targeting of oncogenic NRAS and BRAF drivers as a strategy for mole reversal and melanoma prevention

Novel Antibody Therapeutics: Anti-BCMA.ECD for Personalised Cell Therapy in Multiple Myeloma

DLL3-targeting CAR-T cells enhanced by co-deletion of PD1 exhibit better efficacy and persistence in a pre-clinical animal model for small cell lung cancer

Fishing for new immunotherapy compounds to boost innate-tumor rejection

Preclinical double humanized CD47/SIRPα mouse model and MC38 cell line expressing human CD47 for efficacy and safety assessment of anti-CD47/SIRPΑ-targeting therapies

Development of the in vitro 3D Spheroid High-Throughput Screening Platform for the Development of Immune Checkpoint Inhibitors

Integrating the Fasting-Mimicking Diet to Augment Anti-tumor Immunity following Adoptive Cell Transfer in Breast Cancer.

ROR1-Specific CAR T-Cells: Advancing Targeted Immunotherapy for Cancer

Improved Adoptive T Cell Therapies for Colorectal Liver Metastases by Stabilization of IFNAR1 on Tumor-Specific T-Cells

A Pro-Tumorigenic Cytokine with an Unexpected Anti-Cancer Role: TGFβ Enhances NK cell Immunotherapy for pancreatic cancer

Development of a humanized anti-ANXA3 monoclonal antibody for potential treatment of hepatocellular carcinoma

Tumor-infiltrating immune cell types predicting recurrence-free survival in melanoma patients receiving adjuvant PD-1 inhibitor therapy

Novel Harnessing of Innate and Adaptive Anti-Cancer Immunity: NLRP3-Inflammasome Activation Facilitates Immune Checkpoint Blockade in the Treatment of Mesenchymal Stage IV Colorectal Cancer

Immunopeptidomics approach for the identification of neoantigens in multiple myeloma

Bridging the Gap Between In Vitro and In Vivo: STC-1010 Cancer Vaccine Efficacy in 3D Tumor Spheroids

CAM Assay: An Alternative, 3Rs-compliant, In Vivo Model for the Development of Anticancer Immunotherapies

Targeting UMG1, a highly glycosylated cancer specific CD43 epitope, by a Bispecific T-Cell Engager (BTCE) in Malignant Melanoma

Exploiting human ALK.CAR-T cell therapy for the treatment of ALK+ small cell lung cancer

Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy

Comparative analysis of neoadjuvant PD1+Lenvatinib versus PD1 alone in the tumour immune microenvironment of melanoma: Correlation of immune profiling with pathological response.

Optimized Timing of CD25-Biased IL-2/JES6 (IL-2/IL-2 mAb Complex) Administration Enhances Antitumor Efficacy of Immune Checkpoint Inhibitors

CD25-Biased IL-2/Anti-IL-2 Complexes Enhance Antigen-Primed CD8⁺ T Cell Expansion, Overcome Treg-Mediated Suppression, and Exhibit Significant Antitumor Activity

RALA-PRAME DNA Vaccine: A Novel Immunotherapy for High-Grade Serous Ovarian Carcinoma

Accelerating the Manufacture of γδ T Cells for Allogeneic Cancer Therapies: Integrated Cell Differentiation and Expansion in Bioreactors

Blockade of PD-L1 endocytosis by uPAR antagonist peptides to improve cancer immunotherapy

Impact of Immune Checkpoint Inhibitors on Recurrence Patterns in Early-Stage NSCLC

Targeting solid tumor cell lines of diverse histological origins with nucleolin-specific CAR-T cells - a proof-of-concept

Immunization against a mutant p53-derived neoantigen by a personalized oncolytic adenovirus

IL17A depletion remodels pancreatic tumor matrix and boosts ENO1 vaccine efficacy

Generation of versatile tumor target cell lines using the SpyCatcher/SpyTag system

Development of a faster potency assay for evaluation of immune cell-mediated cytotoxicity in vitro

CAPTN-3: A novel platform of conditionally activated T cell and NK cell engagers

Detecting changes in the tumour microenvironment and in CAR T infiltration following chemotherapeutic priming using intravital imaging

Novel NK Cell Immunotherapy Strategy to Enhance Tumor Killing and Overcome Microenvironment Resistance

Neutrophil serine proteases alter IL-18 to a superkine

Unlocking the Potential of Dendritic Cell-Derived Extracellular Vesicles in Targeting Triple-Negative Breast Cancer

Boosting Melanoma Immunotherapy: Synergizing Nanovaccines with PD-L1 Modulation

Anti-CD19 therapy (Blinatumomab®) as a bridge therapy for hematopoietic stem cell transplantation in pediatric patients with relapsed/refractory B-type acute lymphoblastic leukemia Ph-negative

NK Cell Exhaustion in Multiple Myeloma: Pathways to Novel Immunotherapies

Accelerating immuno-oncology research with flexible workflows using modular Flex-Fit CyTOF panels

RAS(ON) G12C-selective and multi-selective doublet combination overcomes clinical resistance mechanisms to KRAS G12C(OFF) inhibitors and sensitizes to immune checkpoint blockade in preclinical models

Clinical Analysis of CNS WHO Grade 4 Gliomas with IDH-mutant versus IDH-wildtype Focused on CDKN2A Homozygous Deletion

Enhanced antitumor immunity following neoadjuvant chemotherapy in triple-negative breast cancer

Facilitators and barriers of gastroscopy screening in high⁃risk populations for gastric cancer: a qualitative study

Bioinformatics analysis for the identification of key genes and microRNAs related to bone metastasis in prostate cancer

Trends of prostate cancer stage and grade over a 12-year period in Northern Ireland; a population-based analysis

Mapping Genetic Risk Variants for Sporadic Colorectal Cancer in a Brazilian Population: Insights from a Genome-Wide Association Study

Chamosite in Late Permian C1 coal and the high incidence of lung cancer in Xuan Wei

Effect of Pathogenic Mismatch Repair (MMR) Genes on the Systemic Metabolome and Their Link to Cancer Risk in a Lynch Syndrome Cohort

Sociodemographic and clinicopathologic features associated with rapid relapse in triple-negative breast cancer: A Swedish nationwide registry-based study

Exploring the role of monoallelic pathogenic MUTYH variants in colorectal cancer risk: Clinical implications and genetic findings in Serbian population

Changing epidemiology and trends in incidence of childhood acute lymphoblastic leukaemia in Scotland: An analysis of the national cancer registration data, 1971-2020

Implementing cancer prevention strategies in the occupational setting: the Cancer Prevention at Work (CPW) study protocol

Characterize the spatial biology of HPV infection in tissue with multiplexing

Insights into Molecular and Immune Mechanism of Chemo Prevention of Aegle marmelos Fruit Extract: Preclinical and Preventive Strategies in Colitis Associated Colon Cancer Pathogenesis

Personalized Initial Screening Ages for Colorectal Cancer Based on Detailed Family History in Western Europe

Lifestyle intervention during colorectal cancer screening: a pilot study in France

Predictors of colorectal neoplasia among individuals with a family history of CRC aged 40 to 54 years: Objective Risk vs. Perceived Risk

Participant-related risk factors for false positive faecal occult blood test results in screening for colorectal cancer – a systematic review and meta-analysis

Effect of TiO2, as food additive E171 or nanoparticules, on colorectal carcinogenesis and colibactin-producing Escherichia coli virulence

Investigating how Mitochondrial Dysfunction Promotes Breast Carcinogenesis in a Stiff Extracellular Matrix

OUTLIVE-CRC “Improving prognosis and quality of life of young CRC patients: Tertiary prevention through multi-marker models and nutritional interventions”

Prevalence and Clinical Characteristics of High-Risk HPV in Women from Underserved and Remote Regions of Colombia

Menarche, menopause, and female breast cancer risk in China and the UK: comparative findings from three large cohorts

Melanoma and health inequity in the UK

The Impact of Emotional Intelligence on Mental Health: A Protective Factor in Breast Cancer Survivors

Broad-Spectrum Antiviral Activity of Ganoderma Microsporum Immunomodulatory Protein: Targeting Glycoprotein gB to Inhibit EBV and HSV-1 Infections via Viral Fusion Blockage

Evaluating the role of ATM inhibitors in enhancing the efficacy of radiotherapy and their potential to improve the immunosuppressive microenvironment of glioblastoma

Advanced 3D glioblastoma models for investigating radiopharmaceutical therapy

Ro 90-7501 Enhances The Radio-Sensitivity of Breast Cancer Cells by Impairing DNA Double-Strand Break Repair Mechanisms

Impact of Lamin Mutations on Radiation Response in Lung Cancer

Radioresistance of colorectal cancer cells is driven by GPX4 and ferroptosis resistance.

Upconversion Nanoparticle-Mediated Neutron Capture Therapy Lu-177 Treatment in Head and Neck Squamous Cell Carcinoma via the c-MET Signaling Pathway

Treatment of Orthotopic Human GBM Tumours in Mice Using Auger Electron-Emitting 197Hg-Gold Nanoparticles Administered by Convection-Enhanced Delivery

Radiosensitivity and DNA Damage Response in Human Sarcoma: p53-Dependent and Independent Mechanisms Under Alpha-Particle Radiation

Combining Hypoxia and Stemness Biomarkers with Hematoxylin and Eosin Stained Images improves Radiosensitivity Classification in Head and Neck Cancer Preclinical Models

Novel biomarkers for Radiotherapy response in Small Cell Lung Cancer

Investigating the Synergistic Effects of HDAC and ABC Efflux Transporter Inhibitors in Radiation-Resistant Triple Negative Breast Cancer

Radiation-induced effects by external beam radiotherapy in triple-negative breast cancer cellular models with or without BRCA1/2 mutations

Exploring Synergistic Effects of Ionizing Radiation and Asparaginase to Treat Solid Tumors

Assessement of the combination of iron oxide nanoparticles and erastin to radiosensitize head and neck cancer cells

The alpha-emitter radium-223 modulates migration, invasion and angiogenesis in metastatic prostate cancer preclinical models

Normal Human Epithelial-Fibroblast 3D Spheroid Cultures for Modeling Radiation-induced Lung Injury

Response of non-small lung cancer cells to irradiation with helium ions

Revolutionizing Pancreatic Cancer Treatment: The Game-Changing Duo of Radiotherapy and PARP Inhibitors

New insights into the effects of coffee extracts on colon cancer and healthy human cells

Elucidating receptor-mediated modulation of cannabidiol activity in prostate cancer

Role of intracrine VEGFA-VEGFR1 signaling in BRAF mutated melanoma

Decipher the Roles of IL-6 Signaling in CTPS Filament-mediated Cancer Progression

SRF fusions act as hyperactivated transcription factors in pediatric tumors

IL-6/STAT3 Regulates Solid Stress Enhanced Migration and Invasion in Breast Cancer Cells

Uncovering the paraspeckle-dependent and independent role of NONO in transcriptional regulation in Multiple Myeloma

A novel regulator of Hedgehog signaling and stemness in prostate cancer

Elevated temperatures induce PDCD1 expression via HSF1 activation.

Decoding EGFR-Driven Transcriptional Networks in NSCLC

Glucocorticoid signaling regulates luminal A and triple negative subtypes of breast cancer differently on the epithelial-mesenchymal transition pathway

SP1 Downregulates ADAMTS-8 mRNA Expression in Colorectal Cancer Model

IL-6-upregulates MIR100HG gene expression in Hepatocellular Carcinoma

The effects of 17β-estradiol on the expression and functionality of large-conductance voltage- and Ca2+-activated potassium channels in human glioblastoma cells

Unveiling the Molecular Mechanisms of KCa3.1 in Pancreatic Cancer Development

Regulation of MBD4 expression and cell-cycle mediated Interactions with the DNA Mismatch Repair (MMR) pathway

Coordinated Changes in Midkine Expression and Its Receptor Network in Gliomas

Utilising interactomics to map the role of the pancreatic tumour microenvironment in rewiring mutant KRAS signaling

Receptor tyrosine kinases as suitable molecular targets in the precision treatment of giant cell tumor of bone

Natural stilbenes in prostate cancer targeted interception and therapy: pre-clinical studies

Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer

A Tumour Organoid Biobank for Mapping Cancer Cell Vulnerabilities

Treatment response and survival of patients with early-onset compared to older-onset colorectal cancer in the Netherlands

SWOT Analysis for Maintaining the Sustainability of Newly Established Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia

Breast cancer immunotherapy using magnetised oncolytic virus

In vitro strategy to discover therapeutic targets in PDAC

Protein Tyrosine Phosphatase Receptor type Psi (PTPRU) in clinical breast cancer

Ovarian cancer Zebrafish Avatars for personalized multiple drug testing

Malignant Ascites Derived Organoids from Ovarian Cancer Patients for Understanding Platinum Resistance and Approaching Targeted Therapy

BQ323636.1 Overexpression Drives mTOR Signaling and Lipid Metabolism via ACSL4 in ER-positive Breast Cancer

Trametinib for NRAS-mutated tumors: Results from the Drug Rediscovery Protocol (DRUP)

Investigating the Therapeutic and Prognostic Utility of Long Non-Coding RNA Targets and their Association with Tumour Microenvironment in KRAS-Mutant NSCLC

Canine Melanoma as a Translational Model for Novel Immuno-Nanotherapy and Focal Adhesion Kinase-targeted Strategies in Human Oncology

Detection of low frequency variants from low input FFPE samples with comprehensive tumor/normal exome sequencing

M2 macrophages promote survival and proliferation of patient-derived gastric cancer organoids in a tumor biology-dependent manner

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes

Exosomes from urine: A multi-purpose system for urine liquid biopsy

PET imaging of PD1-positive MOLT-4 T-cell lymphoblastic leukemia tumours in NRG mice using 89Zr-labeled pembrolizumab

Beating Breast Cancer Brain Metastases: Leverage Nano-Immunotherapy to Re-educate Host Immunity

PET-based and glycolytic biomarkers reveal 18F-FDG uptake/heterogeneity phenotypes and predict metabolically active disease in aggressive B-cell lymphomas

Engineered v5 PE6A-VLPs Enable In Vivo PCSK9 Gene Editing to Suppress Hepatocellular Carcinoma Progression and Modulate Cholesterol Metabolism

Whole exome sequencing of non-small cell lung cancers in a cohort of patients enriched for genetic tumor risk

Improving intraoperative tumor margin assessment in lung cancer surgeries using the MasSpec Pen technology

Enhancing Anti-Tumor Activity in Pancreatic Cancer by Targeting PI3Kδ and Autotaxin

Loss of the tumor suppressor NUMB drives aggressive bladder cancer via hyperactivation of the RHOA-ROCK-YAP pathway: implications for personalized prognosis and targeted therapy

Innovative Multiomic Spatial Biology Assay for Comprehensive Immune Profiling of the Tumor Microenvironment

Artificial intelligence predicts prognostic features of patient survival related to microvascular invasion and molecular classes of hepatocellular carcinoma

Preclinical combination of selenium nanoparticles and a nanovaccine demonstrates immunotherapeutic properties against luminal B breast cancer

Hyaluronic Acid-Coated Nanoparticles for Targeted Delivery in Colorectal Cancer: Unlocking the Potential of CD44-Dependent Therapy

Building precision oncology via real-world data standardization, privacy preserving infrastructures, and collaboration among IT and clinical experts: TheDIGICORE network experience

3D printing in microfluidic device prototyping for cancer research

Characterisation of the Colon Adenocarcinoma microenvironment with a focus on Natural Killer Cells

Tissue-Engineered Human 3D Tumor Models for Predictive Preclinical Anti-Cancer Therapy Assessment

Organotypic Slice Cultures as a Feasible Predictive Model for Carboplatin Response in High-Grade Serous Ovarian Cancer (TOSCA Study)

Advanced Biomonitoring System for Colorectal Cancer Survivors: Enhancing Early Detection and Continuous Monitoring of Anastomotic Dehiscence

Cancer cell therapy using gold-doped carbon dots for biorthogonal catalysis

Establishing Robust In Vitro and In Vivo Models of Mesothelioma for Enhanced Translational Research

Cytotoxicity of novel multifunctional carbon nanocapsules

A systematic review of Cancer spontaneous remission (CSR) and post-radiation abscopal responses (p-rAR)

A deep-learning approach for tissue mapping and cell phenotyping in imaging mass cytometry data analysis

The Role of SLCO1B1 and SLCO1B3 Transporters in Breast Cancer Imaging.

Heterogenous tumor immune microenvironment in mismatch repair deficient colorectal cancer patients receiving immune checkpoint inhibitor

The Effects of Palmitic Acid and Insulin as Diabetic Stress Markers in Breast Cancer Associated Fibroblast Model in vitro

Tumor budding cells express Trop-2 as a driver of colon cancer cell migration and invasion

Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia

The prostate specific SOCS1-deficient mouse model to study the gut-prostate axis in the pathogenesis of prostate cancer

LncRNA PRKCQ-AS1 promotes cancer cell proliferation and inhibits etoposide-induced apoptosis via modulation of HOX5A.

Erythrocyte-derived sphingosine-1-phosphate promotes tumor cell survival in the circulation

Deciphering the Role of TCF21 in Regulating the Cancer-Associated Fibroblast (CAF) State in High Grade Serous Ovarian Cancer

Defining the metastatic niche for colorectal cancer dissemination

Transcriptomics analysis identifies intronic RNAs in ER+/PR+ and HER2-enriched ductal breast carcinoma

Patterns of Bone Marrow Adipogenesis in Response to Chemotherapy

Reprogramming the immunosuppressive tumor microenvironment to overcome resistance to CAR T-cell immunotherapy in pancreatic cancer

The role of the neuronal-cancer crosstalk in melanoma brain metastases using hPSC-derived Assembloids

Immunomodulation of Glioblastoma Tumor Microenvironment by NF1-LRD-Loaded Extracellular Vesicles

Combined K8 and Apc loss-derived mouse model for colon-specific tumorigenesis

Impact of MAG-EPA supplementation on the prostate tumor immune microenvironment

Local and systemic interactions drive prostatic intraductal carcinoma dissemination.

Colorectal cancer hepatic metastasis modelling by advanced 3D bioprinting and demonstration of oncolytic viral chemotherapeutic delivery.

Three-dimensional Microtissues: An In-Vitro Platform to Recapitulate the Heterogeneity and Complexity of Head and Neck Squamous Cell Carcinoma

Tissue-specific fibroblast lipids drive epithelial cancer invasion

MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer- associated fibroblasts

Reprogramming of cancer-associated fibroblasts during the stepwise progression of colorectal cancer

Elucidating the molecular mechanisms involved in pancreatic cancer and liver microenvironment crosstalk facilitating liver metastasis

A novel approach for the analysis of spatial cell distributions in the tumor microenvironment to predict bevacizumab response

The role of the Hippo signaling pathway in gastric cancer initiation and progression

Neoadjuvant chemotherapy modulates the tumor immune microenvironment in ovarian cancer based on homologous recombination status

Characterization of Dormant Persistor Origins Using Longitudinal Live Imaging

Dysadherin-mediated CA9 expression shapes an acidic tumor microenvironment to accelerate colorectal cancer aggression

A novel TROP2 complex affects colon cancer mechanobiology by modulating the cytoskeleton architecture

Understanding the genetic heterogeneity within clonal spheroids and its interaction with the tumor microenvironment

MLK4 role in the cross-talk between triple-negative breast cancer cells and tumour-associated macrophages.

Secretomes of IFN-γ-Activated Colon Endothelial Cells Suppress Colorectal Cancer: Molecular Insights and Cell-Biological Effects

FOXM1 as a Key Regulator of Brain Metastasis Breast Cancer

Exploring small nucleolar RNAs as predictors of radiotherapy outcome in breast cancer

The impact of CFTR impairment on endothelial cell and its role during tumor progression

Emerging Subtypes in Ovarian High Grade Serous Carcinoma: Decoding Genomic and Functional Landscapes

Establishing the Immune-Profile of Cholangiocarcinoma and the Utility of Human Precision-Cut Tumour Slices (hPCTS) as a Platform to Assess Immunotherapy Response

Secreted luciferases: a scalable, accessible, and 3R-compliant tool for longitudinal monitoring of autochthonous tumor growth in vivo

Understanding the Role of Leukemia Inhibitory Factor (LIF) in the Bone Metastatic Microenvironment

Monocyte/macrophage crosstalk with colorectal cancer in co-cultures - in vitro studies

Cellular enlargement causes mitotic errors and aneuploidy in cells that evade senescence following chemotherapy

Characterization of hPBMC-ASID and hPBMC-ASIDβ2m−/− models for Immune-Oncology Studies

Unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.

Cholesterol Transfer from PI-Activated TREM2+ Macrophages to Tregs Drives Lymph Node Immunosuppressive Pre-Metastatic Niche

Translational Value of Hepatic Dnaja3-deficient Mice in Preclinical Testing of Novel HCC Therapeutics

Autophagy activation in response to cigarette smoke: Exploring the disparity in laryngeal cancer incidence and outcomes between sexes in South Korea