Detailed Programme - 18 June 2025

• Introduction
  HardcastleTravis Industry Moderator/ Chair United States
• Unveiling SURF2’sRole in Nucleolar Stress and Its Potential as a Therapeutic Target
  LebaronSimon Industry Speaker France
• AI-driven identification and validation of novel synthetic lethal gene pairs
  MillerDaniel Industry Speaker United Kingdom
• Leveraging an advanced CRISPR platform to streamline oncology breakthroughs
  SoenensAmalia Industry Speaker

• Transposable elements reorganise the 3D genome structure in CDK4/6 inhibitors resistant breast cancer.
  Achinger-KaweckaJoanna Industry Speaker Australia

• Advancing Science Through Industry-Academic Collaboration: Pre-Clinical Development of KRAS Modulators
  HofmannMarco Speaker Austria
• Tumor Archetypes Reimagined: Multi-Omic Insights, AI-Driven Discovery, and New Frontiers in Cancer Subtyping
  SinaNassiri Speaker Switzerland
• Discussion with the Experts

• Drugging transcription factors: HSF1 and Brachyury
  WorkmanPaul Speaker United Kingdom
• Proffered Paper: Inhibition of WEE1 kinase activity to overcome secondary resistance to targeted therapies in colorectal cancer
  EACR25-0376
  EACR25-0376
  ArenaSabrina Presenter Italy
• Targeting chromatin proteins for therapeutic benefit in haematological malignancy
  SomervailleTim Speaker United Kingdom
• Proffered Paper: Reversing Acidic Immune Suppression in Cancer with PTT-4256, A First-In-Class Small Molecule Inhibitor of GPR65
  EACR25-0553
  EACR25-0553
  CorbinAlastair Presenter United Kingdom
• PP2A inhibitor protein CIP2A is a prime target for TNBC therapy
  WestermarckJukka Speaker Finland

• The neural regulation of small cell lung cancer progression
  VenkateshHumsa Speaker United States
• Proffered Paper: Medullary sinus macrophages limit cancer therapy efficacy by an efferocytosis-induced IL-33/ST2 axis in the tumor-draining lymph node.
  EACR25-1319
  EACR25-1319
  LamorteSara Presenter Canada
• Neural mechanisms of brain tumor growth and resistance
  WinklerFrank Speaker Germany
• Proffered Paper: Spatially Resolved Analysis of Cancer-Infiltrated Nerves Identifies DRAXIN as a Marker of Injury Response with Tumor-Suppressive Potential
  EACR25-1355
  EACR25-1355
  OzgaJoannaAleksandra Presenter Switzerland
• Neural-tumour communication accelerates cancer progression and impairs treatment response
  SloanErica Speaker Australia

• Clonal evolution of cancer from initiation to metastasis in the mouse (REMOTE Presentation)
  BalmainAllan Speaker United States
• Proffered Paper: Pancreatic Cancer Initiation: Wnt Signalling and Cell Dormancy Enable Kras Mutant Cell Survival
  EACR25-0647
  EACR25-0647
  SalvadorBeatriz Presenter United Kingdom
• PEDIA-BRAIN: Building a normal brain tissue development encyclopedia as a comparator for pediatric CNS malignancies
  MardisElaine R. Speaker United States
• Proffered Paper: Dietary Histidine controls intestinal stem cell activity, providing a potential protective role against colorectal cancer
  EACR25-0457
  EACR25-0457
  BiehlerCornélia Presenter Finland
• Somatic evolution in normal tissues and cancer risk
  RisquesRosana Speaker United States

• Label-free spheroids and organoids analysis for assays development
  VettoreNicola Industry Speaker Germany

• Epigenetic dysregulation and cancer evolution
  ScaffidiPaola Speaker Italy
• Proffered Paper: Integrative multi-omic approach to identify patterns of immune selection in primary breast tumours
  EACR25-0508
  EACR25-0508
  MonterdeBeatriz Presenter United Kingdom
• EMBO Young Investigator Lecture: Cancer aneuploidy - From evolutionary pressures to cellular vulnerabilities (REMOTE PRESENTATION)
  Ben-DavidUri Speaker Israel
• Proffered Paper: Genetic background sets the trajectory of cancer evolution
  EACR25-2424
  EACR25-2424
  AitkenJSarah Presenter United States
• Title to be announced
  TurajlicSamra Speaker United Kingdom

• Cell plasticity in human colon and cancer
  SnippertHugo Speaker Netherlands
• Proffered Paper: Contact-based transfer of thymidylate promotes collective tumor growth
  EACR25-0343
  EACR25-0343
  SiddiquiMohammad Aarif Presenter Denmark
• Development of advanced immunotherapies using human 3D-bioprinted cancer avatars
  Satchi-FainaroRonit Speaker Israel
• Proffered Paper: Deconvolution of heterogeneous 3D mammary spheroid dynamics using Oblique Plane Microscopy (OPM)
  EACR25-2342
  EACR25-2342
  ModerauNina Presenter United Kingdom
• Deciphering the role of infection and diet in driving early carcinogenic events using advanced organoid models and omics
  ChumduriCindrilla Speaker Denmark

• Studying melanoma therapy resistance one cell at the time
  MarineJean-Christophe Speaker Belgium
• Proffered Paper: Dynamics and chemotherapy response of single cell-derived human breast cancer clones
  EACR25-0507
  EACR25-0507
  KronheimRachaelSarah Presenter Canada
• The role of RANK signaling in breast cancer biology and response to therapy
  CasimiroSandra Speaker Portugal
• Proffered Paper: Unveiling the impact of intratumoral microbiota in the treatment efficacy of soft tissue sarcoma
  EACR25-0716
  EACR25-0716
  TiraboschuiLuca Presenter Italy
• Mechanism of response and resistance to RAS inhibition in solid tumors
  MisaleSandra Speaker United States

• Unravelling mechanisms of ER+ Breast cancer dormancy
  GomisRoger Speaker Spain
• Proffered Paper: Translational Reprogramming Drives Immune Evasion in Melanoma Persister Cells Through MIF Secretion
  EACR25-2481
  EACR25-2481
  SoumoyLaura Presenter France
• What makes a tissue favorable or not to metastasis?
  Luisa CorreiaAna Speaker Portugal
• Proffered Paper: Neuroblastoma metastatic cells adopt an embryonic diapause-like state in the fetal bone marrow driven by mTOR activity
  EACR25-0988
  EACR25-0988
  Castillo FerrerCamila Presenter France
• How host niche variations regulate disseminated cancer cell dormancy and awakening
  Aguirre-GhisoJulio A. Speaker United States

• Title TBC
  Ivan Masetto Industry Speaker
• Title TBC
  HunterKelly Industry Speaker United Kingdom
• Titel TBC
  TissotStéphanie Industry Speaker Switzerland
• Titel TBC
  TissotStéphanie Industry Speaker Switzerland
• Titel TBC
  TissotStéphanie Industry Speaker Switzerland

• Introducing Illumina Single Cell and Spatial Technology
• Scalable single-cell RNA profiling of pooled CRISPR screens discloses novel biology of cancer and T cells
  Van MinselPaulien Industry Speaker Belgium
• Cell Altasing Human Intestine using Illumina Spatial Technology
  ZhuChenchen Industry Speaker United States
• Illumina Connected Multiomics
  ScmidJoachim Industry Speaker Germany

• TCR Repertoires of Tumor-Infiltrating γδ1 T Cells Reveal PD-1–Modulated Reactivity
  MikulakJoanna Industry Speaker Italy

• TABLE 1: How to build your own network
  RisquesRosana Moderator United States
• TABLE 2: Leadership: Experience in combining research with the direction of a research institute
  BardelliAlberto Moderator Italy
• TABLE 3: Leadership: Experience as a team leader and a research center science director
  MarineJean-Christophe Moderator Belgium
• TABLE 4: Life of a scientist between research and hospital
  SomervailleTim Moderator United Kingdom
• TABLE 5: How to make your research impactful and transferable to the clinic
  GomisRoger Moderator Spain
• TABLE 6: How to build a successful lab environment
  WestermarckJukka Moderator Finland
• TABLE 7: How do you know when you are ready to start your own lab?
  TurajlicSamra Moderator United Kingdom
• TABLE 8: Challenges of setting up a new lab and establishing yourself as a PI in your home country after years abroad
  Luisa CorreiaAna Moderator Portugal
• TABLE 9: The challenges of starting your own lab
  VenkateshHumsa Moderator United States
• TABLE 10: ERC funding opportunities for starting or establishing a research group in the EU or Associated Countries
  CaraffiniVeronica Moderator

• TABLE 1: A career at the intersection between cell biology and oncology
  RegenbergBirgitte Moderator Denmark
• TABLE 2: Navigating a career in Academia and Industry
  PaganiMassimiliano Moderator Italy
• TABLE 3: Challenges of being a clinician scientist: Successfully balancing clinical and academic duties
  TaberneroJosep Moderator Spain
• TABLE 4: From fundamental science to translational impact
  de VisserKarin E. Moderator Netherlands
• TABLE 7: Current challenges in academia: tips to survive
  Aguirre-GhisoJulio A. Moderator United States
• TABLE 8: The challenges of starting your own lab
  MisaleSandra Moderator United States
• TABLE 9: Leadership: Experience of a former EACR president
  BernardsRene Moderator Netherlands
• TABLE 10: From performing research to supporting researchers: transitioning from academia to scientific administration
  CaraffiniVeronica Moderator

• Olink Proteomics: Accelerating progress in cancer research and the path to therapeutics
  RUCEVICGuyonnetMarijana Industry Speaker Sweden
• Deep plasma proteomics identifies and validates an eight-protein biomarker panel for ovarian cancer
  EnrothStefan Industry Speaker Sweden
• Liquid biopsy: Plasma proteomics to identify novel biomarkers
  ItalianoAntoine Industry Speaker France
• Questions and Answers

• Introduction to C13 Hyperpolarization
  BennettSimon Industry Speaker Germany
• Applications for imaging and measuring metabolism in vivo
  BennettSimon Industry Speaker Germany
• Q&A

• Unlocking Novel Cancer Biology with Multiomic Insights, Introduction by Chair/ Moderator
  Juarez Eleonora Industry Moderator/ Chair United States
• Bridging genotype and phenotype through single-cell and single-molecule multi-omics
  HarbersLuuk Industry Speaker Belgium
• Tumour heterogeneity and clonal selection of ecDNA at single-cell level
  Deleuran Hendriksen Josephine Industry Speaker Denmark

• Agent-Based Modelling of Gene Networks the tumour microenvironment ecosytem
  BuffaMeteoraFrancesca Speaker United Kingdom
• Proffered Paper: High-throughput drug screening in breast cancer PDTCs enables clinically relevant drug discovery for personalised medicine.
  EACR25-1681
  EACR25-1681
  MasinaRiccardo Presenter United Kingdom
• The power of many: Unlocking treatment response patterns through single-cell meta-analysis (REMOTE PRESENTATION)
  AranDvir Speaker Israel
• Proffered Paper: Spatial and multi-omic profiling of HGSC to identify immune vulnerabilities for precision immunotherapy
  EACR25-0439
  EACR25-0439
  ShabanovaAleksandra Presenter Finland
• Harnessing computational tools to understanding somatic evolution in cancer
  McGranahanNicholas Speaker United Kingdom

• Polygenic risk models and prevention in breast and ovarian cancer
  PharoahPaul Speaker United States
• Proffered Paper: Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer
  EACR25-1604
  EACR25-1604
  BakerAnn-Marie Presenter United Kingdom
• Mechanisms of Lung Cancer Promotion
  HillWilliam Speaker United Kingdom
• Proffered Paper: Tumour genotype shapes blood biomarker expression for use in pancreatic cancer detection and diagnosis
  EACR25-0817
  EACR25-0817
  CanelMarta Presenter United Kingdom
• Investigating the impact of environmental exposures
  LimEmilia Speaker Canada

• DNA repair-dependent immunogenic liabilities in colorectal cancer: the opportunity comes from the errors
  GermanoGiovanni Speaker Italy
• Proffered Paper: Exploit Neutrophil Heterogeneity to induce Synthetic Lethality in Breast Cancer
  EACR25-0256
  EACR25-0256
  CalcinottoArianna Presenter Switzerland
• Immunoprevention in Lynch Syndrome
  DiazLuis Alberto Speaker United States
• Proffered Paper: Intratumoral STING pathway activation enhances anti-tumor immune responses and therapeutic efficacy of ATR inhibition.
  EACR25-0468
  EACR25-0468
  SenTriparna Presenter United States
• Know Your Enemy: Unraveling the Gene Regulatory Networks of Tumor-Infiltrating CD4+ Regulatory T Cells
  PaganiMassimiliano Speaker Italy

• Extrachromosomal DNA (ecDNA): Cancer’s Dynamic Circular Genome
  MischelPaul Salomon Speaker United States
• Proffered Paper: Heterogeneous oncogene dosage driven by extrachromosomal DNA determines neuroblastoma response to therapy
  EACR25-0364
  EACR25-0364
  MontuoriGiulia Presenter Germany
• Functional Role of Extrachromosomal Circular DNA in Colorectal, Renal and Bladder Cancers
  RegenbergBirgitte Speaker Denmark
• Proffered Paper: Investigating the impact of extrachromosomal DNA amplification on cell fate decisions and therapy resistance
  EACR25-2262
  EACR25-2262
  SchmargonRachel Presenter Germany
• A general strategy to model ecDNA-mediated focal amplifications in cells and in mice
  VenturaAndrea Speaker

• A practical guide for adaptive immune receptor repertoire profiling and the characterization of antigen-induced clonotypes with applications in cancer, vaccine development, and autoimmunity
  ChenchikAlex Industry Speaker United States

• Clinical findings in preclinical perspective
  BardelliAlberto Speaker Italy

  BernardsRene Speaker Netherlands
• Introduction on PFS and OS of the BREAKWATER study (1st line)
  TaberneroJosep Speaker Spain
• Clinical Development
  Saoudi GonzálezNadia Speaker Italy

• Dissecting ovarian cancer cellular responses to radioimmunotherapy with β- particle and ultra-short range conversion and Auger electron-emitting radionuclides. (EACR25-0133)
  P-552
  EACR25-0133
  GrzmilMichal Presenter Switzerland
• Pan-cancer analysis of successive whole genome duplication in the 100,000 Genomes Project (EACR25-0555)
  P-746
  EACR25-0555
  SmythEvie Presenter Ireland
• COX-2/PGE2 Activity in Cancer Cells: A Key Driver of Metastasis via Immune Escape (EACR25-0743)
  P-773
  EACR25-0743
  RussoMassimo Presenter United Kingdom
• Depleting tumour-infiltrating Tregs to enhance the efficacy of KRAS-mutant targeted therapies in lung cancer (EACR25-1513)
  P-790
  EACR25-1513
  de CastroAndrea Presenter United Kingdom
• Cytotoxic ILC-1 cells determine outcome of PD-(L)1 blockade in microsatellite instable cancers (EACR25-2039)
  P-522
  EACR25-2039
  Van RoyenPaula Presenter Netherlands